Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascu...
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Published in | Molecular cell Vol. 58; no. 6; pp. 1040 - 1052 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
18.06.2015
Elsevier Cell Press |
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Abstract | Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind related GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.
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•Crystal structures reveal how CGRP and AM peptides bind their heterodimeric receptors•CGRP and AM occupy a shared binding site on CLR with minimal contact to the RAMPs•Peptide binding modes were confirmed for intact receptors in cells by mutagenesis•Peptide selectivity arises from RAMP-specific contacts and subtle alteration of CLR
Booe et al. report two crystal structures that reveal how selectivity of the GPCR CLR for CGRP and AM peptides is modulated by RAMP proteins. The peptides similarly occupy a shared binding site on CLR. RAMPs augment the binding site with distinct contacts to the peptides and subtly alter CLR. |
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AbstractList | Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind related GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.
[Display omitted]
•Crystal structures reveal how CGRP and AM peptides bind their heterodimeric receptors•CGRP and AM occupy a shared binding site on CLR with minimal contact to the RAMPs•Peptide binding modes were confirmed for intact receptors in cells by mutagenesis•Peptide selectivity arises from RAMP-specific contacts and subtle alteration of CLR
Booe et al. report two crystal structures that reveal how selectivity of the GPCR CLR for CGRP and AM peptides is modulated by RAMP proteins. The peptides similarly occupy a shared binding site on CLR. RAMPs augment the binding site with distinct contacts to the peptides and subtly alter CLR. Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind related GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes. Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind related GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes. • Crystal structures reveal how CGRP and AM peptides bind their heterodimeric receptors • CGRP and AM occupy a shared binding site on CLR with minimal contact to the RAMPs • Peptide binding modes were confirmed for intact receptors in cells by mutagenesis • Peptide selectivity arises from RAMP-specific contacts and subtle alteration of CLR Booe et al. report two crystal structures that reveal how selectivity of the GPCR CLR for CGRP and AM peptides is modulated by RAMP proteins. The peptides similarly occupy a shared binding site on CLR. RAMPs augment the binding site with distinct contacts to the peptides and subtly alter CLR. Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascular and lymphatic systems. How peptides selectively bind GPCR:RAMP complexes is unknown. We report crystal structures of CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 Å resolutions, respectively. The peptides similarly occupy a shared binding site on CLR with conformations characterized by a β-turn structure near their C termini rather than the α-helical structure common to peptides that bind related GPCRs. The RAMPs augment the binding site with distinct contacts to the variable C-terminal peptide residues and elicit subtly different CLR conformations. Lastly, the structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes. |
Author | Hay, Debbie L. Poyner, David R. Barwell, James Simms, John Booe, Jason M. Walker, Christopher S. Kuteyi, Gabriel Pioszak, Augen A. Brimble, Margaret A. Jamaluddin, Muhammad A. Warner, Margaret L. Bill, Roslyn M. Harris, Paul W. |
AuthorAffiliation | 2 School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand 3 School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK 4 School of Chemical Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand 1 Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA |
AuthorAffiliation_xml | – name: 2 School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – name: 1 Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA – name: 4 School of Chemical Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – name: 3 School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK |
Author_xml | – sequence: 1 givenname: Jason M. surname: Booe fullname: Booe, Jason M. organization: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA – sequence: 2 givenname: Christopher S. surname: Walker fullname: Walker, Christopher S. organization: School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – sequence: 3 givenname: James surname: Barwell fullname: Barwell, James organization: School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK – sequence: 4 givenname: Gabriel surname: Kuteyi fullname: Kuteyi, Gabriel organization: School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK – sequence: 5 givenname: John surname: Simms fullname: Simms, John organization: School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK – sequence: 6 givenname: Muhammad A. surname: Jamaluddin fullname: Jamaluddin, Muhammad A. organization: School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – sequence: 7 givenname: Margaret L. surname: Warner fullname: Warner, Margaret L. organization: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA – sequence: 8 givenname: Roslyn M. surname: Bill fullname: Bill, Roslyn M. organization: School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK – sequence: 9 givenname: Paul W. surname: Harris fullname: Harris, Paul W. organization: School of Chemical Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – sequence: 10 givenname: Margaret A. surname: Brimble fullname: Brimble, Margaret A. organization: School of Chemical Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – sequence: 11 givenname: David R. surname: Poyner fullname: Poyner, David R. organization: School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK – sequence: 12 givenname: Debbie L. surname: Hay fullname: Hay, Debbie L. organization: School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1142, New Zealand – sequence: 13 givenname: Augen A. surname: Pioszak fullname: Pioszak, Augen A. email: augen-pioszak@ouhsc.edu organization: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25982113$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/1295950$$D View this record in Osti.gov |
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SubjectTerms | Adrenomedullin - chemistry Adrenomedullin - genetics Adrenomedullin - metabolism Amino Acid Sequence Animals BASIC BIOLOGICAL SCIENCES Binding Sites - genetics Calcitonin Gene-Related Peptide - chemistry Calcitonin Gene-Related Peptide - genetics Calcitonin Gene-Related Peptide - metabolism Calcitonin Receptor-Like Protein - chemistry Calcitonin Receptor-Like Protein - genetics Calcitonin Receptor-Like Protein - metabolism Chlorocebus aethiops COS Cells Crystallography, X-Ray Humans Models, Molecular Molecular Sequence Data Mutation Peptides - chemistry Peptides - genetics Peptides - metabolism Protein Binding Protein Multimerization Protein Structure, Secondary Protein Structure, Tertiary Receptor Activity-Modifying Protein 1 - chemistry Receptor Activity-Modifying Protein 1 - genetics Receptor Activity-Modifying Protein 1 - metabolism Receptor Activity-Modifying Protein 2 - chemistry Receptor Activity-Modifying Protein 2 - genetics Receptor Activity-Modifying Protein 2 - metabolism Sequence Homology, Amino Acid |
Title | Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor |
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