Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer

• Published in: Molecular cancer Vol. 18; no. 1; pp. 89 - 18
• Main Authors: Xu, Shouping, Wang, Peiyuan, Zhang, Jian, Wu, Hao, Sui, Shiyao, Zhang, Jinfeng, Wang, Qin, Qiao, Kun, Yang, Weiwei, Xu, Hongbiao, Pang, Da
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.04.2019; BioMed Central; BMC
• Subjects: Adult; Aged; Ai-lncRNA; Alternative splicing; Animals; Antineoplastic agents; Antineoplastic Agents, Phytogenic - pharmacology; Antisense RNA; Autophagosomes - metabolism; Autophagy; Autophagy - drug effects; Autophagy - genetics; Binding sites; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cancer; Cancer patients; Cancer therapies; Cell Line, Tumor; Chemotherapy; Chromatin; Cytotoxicity; Double-stranded RNA; Drug Resistance, Neoplasm - genetics; EGOT; Experiments; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene regulation; Genomes; Health aspects; Heterogeneous-Nuclear Ribonucleoprotein Group F-H - genetics; Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism; Humans; Hypoxia; Immunoprecipitation; Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors; Inositol 1,4,5-Trisphosphate Receptors - genetics; Inositol 1,4,5-Trisphosphate Receptors - metabolism; ITPR1; Medical prognosis; Metabolism; Mice; Mice, Nude; Middle Aged; Novels; Nucleotides; Paclitaxel; Paclitaxel - pharmacology; Phagocytosis; Protein Binding; Protein interaction; Ribonucleic acid; RNA; RNA, Double-Stranded - genetics; RNA, Double-Stranded - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; RNA-protein interactions; Signal Transduction; Survival Analysis; Toxicity; Transcription; Transcription (Genetics); Transcriptome; Tumors; Up-regulation; Xenograft Model Antitumor Assays; United States > US; China; ITPR1; Ai-lncRNA; Autophagy; EGOT; Paclitaxel; Cancer

The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the potential involvement of Ai-lncRNA in paclitaxel sensitivity remains unclear in human cancer....