Effect of exosomal miRNA on cancer biology and clinical applications

• Published in: Molecular cancer Vol. 17; no. 1; pp. 147 - 19
• Main Authors: Sun, Zhenqiang, Shi, Ke, Yang, Shuaixi, Liu, Jinbo, Zhou, Quanbo, Wang, Guixian, Song, Junmin, Li, Zhen, Zhang, Zhiyong, Yuan, Weitang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.10.2018; BioMed Central; BMC
• Subjects: Angiogenesis; Biological markers; Biology; Biomarkers; Biosynthesis; Body fluids; Breast cancer; Cancer; Cancer metastasis; Cancer therapies; Cell proliferation; Communication; Development and progression; Diagnosis; Drug resistance; Exosomal miRNAs; Exosomes; Gene expression; Genetic aspects; Identification; Leukemia; Medical diagnosis; Medical research; Melanoma; Metastases; Metastasis; MicroRNA; MicroRNAs; miRNA; Ovarian cancer; Proteins; Review; RNA polymerase; Therapeutic applications; Vascularization; Biomarkers; Angiogenesis; Exosomal miRNAs; Metastasis; Cancer

Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and uptake of which may involve the endosomal sorting complex required for transport (ESCRT co...