Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

• Published in: Molecular cancer Vol. 18; no. 1; pp. 101 - 19
• Main Authors: Chen, Hong-Tao, Liu, Hao, Mao, Min-Jie, Tan, Yuan, Mo, Xiang-Qiong, Meng, Xiao-Jun, Cao, Meng-Ting, Zhong, Chu-Yu, Liu, Yan, Shan, Hong, Jiang, Guan-Min
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2019; BioMed Central; BMC
• Subjects: Anticancer therapy; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Autophagy; Autophagy - drug effects; Biodegradation; Breast cancer; Cancer; Cancer metastasis; Cancer therapies; Care and treatment; Chromosomes; Epithelial cells; Epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - drug effects; Gene Regulatory Networks - drug effects; Humans; Invasiveness; Kinases; Liver cancer; Medical research; Medicine, Experimental; Mesenchyme; Metabolism; Metabolites; Metastases; Metastasis; Mitochondria; Molecular Targeted Therapy; Motility; Neoplasm Metastasis; Neoplasms - drug therapy; Neoplasms - metabolism; Nutrients; Organelles; Phagocytosis; Proteins; Recycling; Review; Signal Transduction - drug effects; Transcription factors; Tumors; Epithelial-mesenchymal transition; Cancer metastasis; Anticancer therapy; Autophagy

Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depen...