Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer's Mouse Model

• Published in: PloS one Vol. 12; no. 1; p. e0169509
• Main Authors: Song, Yuno, Kim, Hong-Duck, Lee, Min-Kwon, Hong, Il-Hwa, Won, Chung-Kil, Bai, Hyoung-Woo, Lee, Seung Sik, Lee, SungBeom, Chung, Byung Yeoup, Cho, Jae-Hyeon
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2017; Public Library of Science (PLoS)
• Subjects: Acetic acid; Alanine; Alanine transaminase; Alzheimer Disease - drug therapy; Alzheimer Disease - etiology; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - immunology; Amyloid beta-Peptides - metabolism; Amyloid beta-protein; Animal models; Animal tissues; Animals; Antibodies - immunology; Aspartate aminotransferase; Biology and Life Sciences; Brain; Brain - metabolism; Brain - pathology; Care and treatment; Chromosomes; Cytokines; Cytokines - metabolism; Dementia disorders; Disease Models, Animal; Enzyme-linked immunosorbent assay; Epitopes; Ethyl acetate; Etiology; Flavonoids; Flavonoids - pharmacology; Glucosides - pharmacology; Helicoverpa zea; Hippocampus; Immune response; Immune response (humoral); Immune system; Immunofluorescence; Immunoglobulin G; Immunoglobulin M; Infections; Inflammation; Interferon; Interleukin 10; Interleukin 2; Interleukin 4; Liver; Liver - drug effects; Liver - metabolism; Lymphocytes T; Male; Medicine and Health Sciences; Metabolism; Mice; Mice, Transgenic; Neurodegenerative diseases; Neurotoxicity; Older people; Oxidative stress; Pathogenesis; Pathology; Peptide Fragments - metabolism; Plant Extracts - pharmacology; Plaque, Amyloid - drug therapy; Plaque, Amyloid - pathology; Polyphenols; Quantitation; Quantitative analysis; Research and Analysis Methods; Rodents; Senile plaques; Staining; Th2 Cells - immunology; Th2 Cells - metabolism; Toxicity; Turfgrasses; Veterinary colleges; Veterinary medicine; γ-Interferon

Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) co...