Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer's Mouse Model
Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) co...
Saved in:
Published in | PloS one Vol. 12; no. 1; p. e0169509 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
01.01.2017
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models. Here, we examined the preventative effects of EA-CG treatment on the Aβ burden in the Tg (Mo/Hu APPswe PS1dE9) AD mouse model. We have investigated the EA-CG efficacy as novel anti-AD likely preventing amyloid plaques using immunofluorescence staining to visually analyze Aβ40/42 and fibril formation with Thioflavin-S or 6E10 which are the profile of immunoreactivity against epitope Aβ1-16 or neuritic plaque, the quantitation of humoral immune response against Aβ, and the inflammatory cytokine responses (Th1 and Th2) using ELISA and QRT-PCR. To minimize the toxicity of the extracted CG, we addressed the liver toxicity in response to the CG extract treatment in Tg mice using relevant markers, such as aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) measurements in serum. The EA-CG extract significantly reduced the Aβ burden, the concentration of soluble Aβ40/42 protein, and fibril formation in the hippocampus and cortex of the Tg mice treated with EA-CG (50 mg/kg BW/day) for 6 months compared with the Tg mice treated with a normal diet. Additionally, the profile of anti-inflammatory cytokines revealed that the levels of Th2 (interleukin-4 (IL-4) and interleukin-10 (IL-10)) cytokines are more significantly increased than Th1 (interferon-γ (IFN-γ), interleukin-2(IL-2)) in the sera. These results suggest that the EA-CG fraction induces IL-4/IL-10-dependent anti-inflammatory cytokines (Th2) rather than pro-inflammatory cytokines (Th1), which are driven by IL-2/IFN-γ. With regard to the immune response, EA-CG induced an immunoglobulin IgG and IgM response against the EA-CG treatment in the Tg mice. Furthermore, EA-CG significantly ameliorated the level of soluble Aβ42 and Aβ40. Similarly, we observed that the fibril formation was also decreased by EA-CG treatment in the hippocampus and cortex after quantitative analysis with Thioflavin-S staining in the Tg brain tissues. Taken together, our findings suggested that Maysin and its derivative flavonoid compounds in the EA-CG fraction might be beneficial therapeutic treatments or alternative preventative measures to adjuvant for boosting humoral and cellular include immune response and anti-inflammation which may lead to amyloid plaque accumulation in Alzheimer's patients' brains. |
---|---|
AbstractList | Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (A[Beta]) by inhibiting oligomeric A[Beta] in cellular and in vitro models. Here, we examined the preventative effects of EA-CG treatment on the A[Beta] burden in the Tg (Mo/Hu APPswe PS1dE9) AD mouse model. We have investigated the EA-CG efficacy as novel anti-AD likely preventing amyloid plaques using immunofluorescence staining to visually analyze A[Beta]40/42 and fibril formation with Thioflavin-S or 6E10 which are the profile of immunoreactivity against epitope A[Beta]1-16 or neuritic plaque, the quantitation of humoral immune response against A[Beta], and the inflammatory cytokine responses (Th1 and Th2) using ELISA and QRT-PCR. To minimize the toxicity of the extracted CG, we addressed the liver toxicity in response to the CG extract treatment in Tg mice using relevant markers, such as aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) measurements in serum. The EA-CG extract significantly reduced the A[Beta] burden, the concentration of soluble A[Beta]40/42 protein, and fibril formation in the hippocampus and cortex of the Tg mice treated with EA-CG (50 mg/kg BW/day) for 6 months compared with the Tg mice treated with a normal diet. Additionally, the profile of anti-inflammatory cytokines revealed that the levels of Th2 (interleukin-4 (IL-4) and interleukin-10 (IL-10)) cytokines are more significantly increased than Th1 (interferon-[gamma] (IFN-[gamma]), interleukin-2(IL-2)) in the sera. These results suggest that the EA-CG fraction induces IL-4/IL-10-dependent anti-inflammatory cytokines (Th2) rather than pro-inflammatory cytokines (Th1), which are driven by IL-2/IFN-[gamma]. With regard to the immune response, EA-CG induced an immunoglobulin IgG and IgM response against the EA-CG treatment in the Tg mice. Furthermore, EA-CG significantly ameliorated the level of soluble A[Beta]42 and A[Beta]40. Similarly, we observed that the fibril formation was also decreased by EA-CG treatment in the hippocampus and cortex after quantitative analysis with Thioflavin-S staining in the Tg brain tissues. Taken together, our findings suggested that Maysin and its derivative flavonoid compounds in the EA-CG fraction might be beneficial therapeutic treatments or alternative preventative measures to adjuvant for boosting humoral and cellular include immune response and anti-inflammation which may lead to amyloid plaque accumulation in Alzheimer's patients' brains. Alzheimer’s disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models. Here, we examined the preventative effects of EA-CG treatment on the Aβ burden in the Tg (Mo/Hu APPswe PS1dE9) AD mouse model. We have investigated the EA-CG efficacy as novel anti-AD likely preventing amyloid plaques using immunofluorescence staining to visually analyze Aβ40/42 and fibril formation with Thioflavin-S or 6E10 which are the profile of immunoreactivity against epitope Aβ1–16 or neuritic plaque, the quantitation of humoral immune response against Aβ, and the inflammatory cytokine responses (Th1 and Th2) using ELISA and QRT-PCR. To minimize the toxicity of the extracted CG, we addressed the liver toxicity in response to the CG extract treatment in Tg mice using relevant markers, such as aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) measurements in serum. The EA-CG extract significantly reduced the Aβ burden, the concentration of soluble Aβ40/42 protein, and fibril formation in the hippocampus and cortex of the Tg mice treated with EA-CG (50 mg/kg BW/day) for 6 months compared with the Tg mice treated with a normal diet. Additionally, the profile of anti-inflammatory cytokines revealed that the levels of Th2 (interleukin-4 (IL-4) and interleukin-10 (IL-10)) cytokines are more significantly increased than Th1 (interferon-γ (IFN-γ), interleukin-2(IL-2)) in the sera. These results suggest that the EA-CG fraction induces IL-4/IL-10-dependent anti-inflammatory cytokines (Th2) rather than pro-inflammatory cytokines (Th1), which are driven by IL-2/IFN-γ. With regard to the immune response, EA-CG induced an immunoglobulin IgG and IgM response against the EA-CG treatment in the Tg mice. Furthermore, EA-CG significantly ameliorated the level of soluble Aβ42 and Aβ40. Similarly, we observed that the fibril formation was also decreased by EA-CG treatment in the hippocampus and cortex after quantitative analysis with Thioflavin-S staining in the Tg brain tissues. Taken together, our findings suggested that Maysin and its derivative flavonoid compounds in the EA-CG fraction might be beneficial therapeutic treatments or alternative preventative measures to adjuvant for boosting humoral and cellular include immune response and anti-inflammation which may lead to amyloid plaque accumulation in Alzheimer’s patients’ brains. Alzheimer’s disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models. Here, we examined the preventative effects of EA-CG treatment on the Aβ burden in the Tg (Mo/Hu APPswe PS1dE9) AD mouse model. We have investigated the EA-CG efficacy as novel anti-AD likely preventing amyloid plaques using immunofluorescence staining to visually analyze Aβ40/42 and fibril formation with Thioflavin-S or 6E10 which are the profile of immunoreactivity against epitope Aβ1–16 or neuritic plaque, the quantitation of humoral immune response against Aβ, and the inflammatory cytokine responses (Th1 and Th2) using ELISA and QRT-PCR. To minimize the toxicity of the extracted CG, we addressed the liver toxicity in response to the CG extract treatment in Tg mice using relevant markers, such as aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) measurements in serum. The EA-CG extract significantly reduced the Aβ burden, the concentration of soluble Aβ40/42 protein, and fibril formation in the hippocampus and cortex of the Tg mice treated with EA-CG (50 mg/kg BW/day) for 6 months compared with the Tg mice treated with a normal diet. Additionally, the profile of anti-inflammatory cytokines revealed that the levels of Th2 (interleukin-4 (IL-4) and interleukin-10 (IL-10)) cytokines are more significantly increased than Th1 (interferon-γ (IFN-γ), interleukin-2(IL-2)) in the sera. These results suggest that the EA-CG fraction induces IL-4/IL-10-dependent anti-inflammatory cytokines (Th2) rather than pro-inflammatory cytokines (Th1), which are driven by IL-2/IFN-γ. With regard to the immune response, EA-CG induced an immunoglobulin IgG and IgM response against the EA-CG treatment in the Tg mice. Furthermore, EA-CG significantly ameliorated the level of soluble Aβ42 and Aβ40. Similarly, we observed that the fibril formation was also decreased by EA-CG treatment in the hippocampus and cortex after quantitative analysis with Thioflavin-S staining in the Tg brain tissues. Taken together, our findings suggested that Maysin and its derivative flavonoid compounds in the EA-CG fraction might be beneficial therapeutic treatments or alternative preventative measures to adjuvant for boosting humoral and cellular include immune response and anti-inflammation which may lead to amyloid plaque accumulation in Alzheimer’s patients’ brains. |
Audience | Academic |
Author | Bai, Hyoung-Woo Lee, SungBeom Won, Chung-Kil Cho, Jae-Hyeon Kim, Hong-Duck Song, Yuno Hong, Il-Hwa Chung, Byung Yeoup Lee, Min-Kwon Lee, Seung Sik |
AuthorAffiliation | 3 Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea 2 Department of Environmental Health Science, New York Medical College, Valhalla, New York, United States of America Cedars-Sinai Medical Center, Maxine-Dunitz Neurosurgical Institute, UNITED STATES 1 Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea |
AuthorAffiliation_xml | – name: 1 Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea – name: 3 Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea – name: 2 Department of Environmental Health Science, New York Medical College, Valhalla, New York, United States of America – name: Cedars-Sinai Medical Center, Maxine-Dunitz Neurosurgical Institute, UNITED STATES |
Author_xml | – sequence: 1 givenname: Yuno surname: Song fullname: Song, Yuno organization: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea – sequence: 2 givenname: Hong-Duck surname: Kim fullname: Kim, Hong-Duck organization: Department of Environmental Health Science, New York Medical College, Valhalla, New York, United States of America – sequence: 3 givenname: Min-Kwon surname: Lee fullname: Lee, Min-Kwon organization: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea – sequence: 4 givenname: Il-Hwa surname: Hong fullname: Hong, Il-Hwa organization: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea – sequence: 5 givenname: Chung-Kil surname: Won fullname: Won, Chung-Kil organization: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea – sequence: 6 givenname: Hyoung-Woo surname: Bai fullname: Bai, Hyoung-Woo organization: Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea – sequence: 7 givenname: Seung Sik surname: Lee fullname: Lee, Seung Sik organization: Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea – sequence: 8 givenname: SungBeom surname: Lee fullname: Lee, SungBeom organization: Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea – sequence: 9 givenname: Byung Yeoup surname: Chung fullname: Chung, Byung Yeoup organization: Advanced Radiation Technology Institute, Korea Atomic Energy Institute, Jeongeup, Korea – sequence: 10 givenname: Jae-Hyeon surname: Cho fullname: Cho, Jae-Hyeon organization: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Korea |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28072821$$D View this record in MEDLINE/PubMed |
BookMark | eNptUl1v0zAUjRCIfcA_QGCJB4ZEi7-TvCBVZWOVNlGx8Ww5yXXrLbFL7HQqv5Efhcu6aUNTHuLcnHN87r3nIHvuvIMse0PwmLCcfL7yQ-90O16l8hgTWQpcPsv2ScnoSFLMnj8472UHIVxhLFgh5ctsjxY4pwUl-9mfc70J1iHtGjSLAZ20eu2dtw36Cr1d62jXgEzvOzQFF-0KGlj0OgQ0iRHcoCOkY7dpt4x5q38N6bvaoJlrhjpat0CnQ-d73aJZ1w0O0A8IyXAAdGPjEl0uKbq4hhto0HQT_bV9iEiu4hLQ5QIdTebzcAOf0PyCNMflRzRpfy_BdtB_COjcDwl87htoX2UvjG4DvN69D7OfJ8eX09PR2fdvs-nkbFRLKuNISpxLyaEwEmuBRSko46lmeCWNFnUjirKqCK6lKDRrciE5rxiBnApREGPYYfbuVnfV-qB2iwiKFCJnEhdCJsTsFtF4faVWve10v1FeW_Wv4PuF0n20dQuK0LwqMDEFBcKNqCrKgMucCGEI1GWdtL7sbhuqDpo67SEN9JHo4z_OLtXCr5WglJf51szRTqD32wVF1dlQQ9tqB2l4ybcsGOaE8QR9_x_06e52qIVODVhnfLq33oqqCc9zjLksy4QaP4FKTwOdrVNqjU31RwR-S6h7H0IP5r5HgtU283dm1Dbzapf5RHv7cD73pLuQs7-SJQEG |
CitedBy_id | crossref_primary_10_1016_j_bbr_2020_112968 crossref_primary_10_14710_dmj_v12i5_39577 crossref_primary_10_3389_fnmol_2021_792364 crossref_primary_10_1002_cbdv_202200940 crossref_primary_10_1002_prot_26423 crossref_primary_10_1093_jn_nxab328 crossref_primary_10_1155_2020_8704146 crossref_primary_10_3233_JIN_170051 crossref_primary_10_1080_13543776_2020_1815706 crossref_primary_10_3390_nu14245373 crossref_primary_10_1021_acschemneuro_8b00010 crossref_primary_10_1021_acs_jafc_8b03865 crossref_primary_10_1007_s13596_021_00573_8 |
Cites_doi | 10.1016/0166-2236(95)93897-7 10.1023/A:1015560116208 10.1016/S0166-2236(97)01168-5 10.1523/JNEUROSCI.4225-04.2005 10.1037/neu0000147 10.1007/BF00988078 10.1073/pnas.94.6.2095 10.1016/j.imlet.2007.06.006 10.1016/j.freeradbiomed.2006.08.015 10.5607/en.2013.22.2.84 10.1371/journal.pone.0016564 10.1002/gps.657 10.1002/ptr.2940 10.3945/jn.112.169516 10.1097/WNN.0b013e3181df3034 10.3233/JAD-121444 10.1016/S0149-7634(98)00039-6 10.4103/2225-4110.136540 10.1073/pnas.94.9.4526 10.1016/j.neuint.2010.12.017 10.1002/ajmg.1320440512 10.1002/jnr.1064 10.1159/000355461 10.1016/j.neuroscience.2009.05.009 10.1603/0022-0493-94.2.564 10.1002/ptr.2275 10.1093/brain/awt062 10.1074/jbc.M508246200 10.2174/1567205012666150204121719 10.1155/2016/3245935 10.1159/000094972 10.3233/JAD-2002-4309 10.1093/infdis/jiu437 10.1603/0022-0493-95.6.1303 10.1016/j.molmed.2007.12.002 10.3233/JAD-2011-110623 10.1126/science.8346443 10.2353/ajpath.2009.090417 10.1212/01.WNL.0000143060.98164.1A 10.1016/j.neulet.2005.12.063 10.1111/j.1749-6632.2000.tb05552.x 10.1016/j.neuint.2010.02.017 10.1016/S0006-8993(97)00824-X 10.1016/B978-0-12-800149-3.00005-6 10.1002/jgm.993 10.3233/JAD-2007-12108 10.1016/S0891-5849(02)01049-3 10.1007/s12272-014-0351-3 10.1016/j.brainres.2008.02.107 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2017 Public Library of Science This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PIMPY PQEST PQQKQ PQUKI PRINS PTHSS PYCSY RC3 5PM DOA |
DOI | 10.1371/journal.pone.0169509 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Complete (ProQuest Database) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Agricultural & Environmental Science ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic Technology Collection Technology Research Database Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) |
DatabaseTitleList | AIDS and Cancer Research Abstracts Agricultural Science Database MEDLINE |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Veterinary Medicine |
DocumentTitleAlternate | Anti-Alzheimer Effects of Centipedegrass |
EISSN | 1932-6203 |
Editor | Koronyo-Hamaoui, Maya |
Editor_xml | – sequence: 1 givenname: Maya surname: Koronyo-Hamaoui fullname: Koronyo-Hamaoui, Maya |
ExternalDocumentID | 1857360856 oai_doaj_org_article_127b801f82e14f5bb23e467155f1ec9c 4298282281 A477004699 10_1371_journal_pone_0169509 28072821 |
Genre | Journal Article |
GroupedDBID | --- 123 29O 2WC 3V. 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV ADRAZ AEAQA AENEX AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CGR CS3 CUY CVF D1I D1J D1K DIK DU5 E3Z EAP EAS EBD ECM EIF EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ NPM O5R O5S OK1 P2P P62 PATMY PDBOC PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RIG RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX CITATION 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PQEST PQUKI PRINS RC3 5PM AAPBV ABPTK |
ID | FETCH-LOGICAL-c626t-6607664e8f60a50595234607f4b6fa5cd589bb10c658a3d75644b31e725581ff3 |
IEDL.DBID | RPM |
ISSN | 1932-6203 |
IngestDate | Sun Nov 05 00:20:57 EDT 2023 Fri Jul 05 11:52:31 EDT 2024 Tue Sep 17 21:24:01 EDT 2024 Wed Jul 24 18:37:29 EDT 2024 Fri Sep 13 07:27:16 EDT 2024 Thu Feb 22 23:40:01 EST 2024 Fri Feb 02 04:05:55 EST 2024 Fri Aug 23 00:35:42 EDT 2024 Sat Sep 28 08:01:08 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Creative Commons CC0 public domain |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c626t-6607664e8f60a50595234607f4b6fa5cd589bb10c658a3d75644b31e725581ff3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: HDK CKW BYC JHC.Formal analysis: HDK IHH CKW.Funding acquisition: JHC.Investigation: YS MKL HWB SSL SL.Methodology: YS MKL HWB SSL SL.Writing – original draft: HDK JHC.Writing – review & editing: HDK JHC. |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224976/ |
PMID | 28072821 |
PQID | 1857360856 |
PQPubID | 1436336 |
ParticipantIDs | plos_journals_1857360856 doaj_primary_oai_doaj_org_article_127b801f82e14f5bb23e467155f1ec9c pubmedcentral_primary_oai_pubmedcentral_nih_gov_5224976 proquest_miscellaneous_1868304134 proquest_journals_1857360856 gale_infotracmisc_A477004699 gale_infotracacademiconefile_A477004699 crossref_primary_10_1371_journal_pone_0169509 pubmed_primary_28072821 |
PublicationCentury | 2000 |
PublicationDate | 2017-01-01 |
PublicationDateYYYYMMDD | 2017-01-01 |
PublicationDate_xml | – month: 01 year: 2017 text: 2017-01-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
PublicationTitle | PloS one |
PublicationTitleAlternate | PLoS One |
PublicationYear | 2017 |
Publisher | Public Library of Science Public Library of Science (PLoS) |
Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
References | 16902278 - Dement Geriatr Cogn Disord. 2006;22(3):238-43 11288146 - J Neurosci Res. 2001 Apr 15;64(2):183-92 17851196 - J Alzheimers Dis. 2007 Aug;12(1):73-92 21305046 - PLoS One. 2011 Jan 28;6(1):e16564 23717280 - Front Pharmacol. 2013 May 13;4:59 20211212 - Neurochem Int. 2010 May-Jun;56(6-7):780-8 23364141 - J Alzheimers Dis. 2013;34(1):115-31 12226538 - J Alzheimers Dis. 2002 Jun;4(3):193-201 27678025 - Expert Opin Emerg Drugs. 2016 Dec;21(4):377-391 25108028 - J Infect Dis. 2015 Jan 15;211(2):230-7 9464679 - Trends Neurosci. 1998 Jan;21(1):15-9 19442706 - Neuroscience. 2009 Sep 15;162(4):1232-43 18218341 - Trends Mol Med. 2008 Feb;14(2):45-53 18457818 - Brain Res. 2008 Jun 12;1214:177-87 24672477 - Front Aging Neurosci. 2014 Mar 14;6:42 19893028 - Am J Pathol. 2009 Dec;175(6):2557-65 20829670 - Cogn Behav Neurol. 2010 Sep;23(3):199-204 23468550 - J Nutr. 2013 May;143(5):597-605 12419469 - Free Radic Biol Med. 2002 Nov 15;33(10 ):1372-9 17686533 - Immunol Lett. 2007 Sep 15;112(1):30-8 12539846 - J Econ Entomol. 2002 Dec;95(6):1303-7 27429978 - Biomed Res Int. 2016;2016:3245935 12064358 - Neurochem Res. 2002 May;27(5):417-21 25161917 - J Tradit Complement Med. 2014 Jul;4(3):140-4 19610032 - Phytother Res. 2010 Jan;24 Suppl 1:S102-8 15788759 - J Neurosci. 2005 Mar 23;25(12):3032-40 9114023 - Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4526-31 9861617 - Neurosci Biobehav Rev. 1998;23(1):131-9 1481815 - Am J Med Genet. 1992 Nov 15;44(5):591-7 25853960 - Pharm Biol. 2015;53(9):1260-6 16423463 - Neurosci Lett. 2006 May 1;398(1-2):124-8 9122152 - Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2095-7 7778188 - Trends Neurosci. 1995 Apr;18(4):172-6 24286330 - BMB Rep. 2014 Jul;47(7):382-7 21185897 - Neurochem Int. 2011 Feb;58(3):399-403 16162502 - J Biol Chem. 2005 Nov 11;280(45):37377-82 24988985 - Arch Pharm Res. 2014 Oct;37(10 ):1354-63 25654508 - Curr Alzheimer Res. 2015;12(2):116-46 8346443 - Science. 1993 Aug 13;261(5123):921-3 21785188 - J Alzheimers Dis. 2011;27(1):143-53 17219449 - J Gene Med. 2007 Feb;9(2):88-98 23576130 - Brain. 2013 May;136(Pt 5):1383-98 25365563 - Neuropsychology. 2015 May;29(3):382-7 25311924 - Adv Genet. 2014;87:245-94 11193785 - Ann N Y Acad Sci. 2000;924:1-7 8892343 - Neurobiol Aging. 1996 Sep-Oct;17(5):707-16 17157181 - Free Radic Biol Med. 2006 Dec 15;41(12 ):1781-94 17724765 - Phytother Res. 2008 Jan;22(1):108-12 12112163 - Int J Geriatr Psychiatry. 2002 Jul;17(7):649-51 9383018 - Brain Res. 1997 Oct 10;771(1):147-53 24264322 - J Chem Ecol. 1990 Sep;16(9):2677-90 24192327 - Neurodegener Dis. 2014;13(2-3):131-4 11332855 - J Econ Entomol. 2001 Apr;94(2):564-71 23833557 - Exp Neurobiol. 2013 Jun;22(2):84-95 15534260 - Neurology. 2004 Nov 9;63(9):1702-4 SE Lesné (ref43) 2013; 136 HY Cheng (ref37) 2010; 24 BZ Guo (ref53) 2001; 94 JS Goldman (ref25) 2002; 17 J Kountouras (ref11) 2010; 23 MA LaFontaine (ref9) 2002; 27 JS Choi (ref35) 2014; 37 HD Kim (ref22) 2007; 9 GP Lim (ref47) 2005; 25 T Hamaguchi (ref46) 2009; 175 DA Butterfield (ref38) 2002; 4 GL Caldeira (ref40) 2013; 34 L Rojanathammanee (ref52) 2013; 143 RL Neve (ref33) 1998; 21 V Chouraki (ref41) 2014; 87 J Hardy (ref24) 1997; 94 F Longpré (ref51) 2006; 41 H Karlinsky (ref1) 1992; 44 C Cecchi (ref10) 2002; 33 R Hamidpour (ref15) 2014; 4 A Eckert (ref26) 2001; 64 A Serretti (ref27) 2007; 12 DA Farsi (ref19) 2008; 22 F Yin (ref48) 2011; 58 P Piscopo (ref34) 2006; 398 R Liu (ref36) 2009; 162 BG Rector (ref18) 2002; 95 J Lee (ref54) 2014; 47 MP Mattson (ref8) 1997; 771 G.M Pasinetti (ref28) 1996; 17 PV Reddy (ref42) 2010; 56 K Rezai-Zadeh (ref50) 2008; 1214 A Frydman-Marom (ref14) 2011; 6 RE Davis (ref30) 1997; 94 EH Corder (ref31) 1993; 261 J Wang (ref55) 2014; 14 F Panza (ref12) 2016; 6 AR Giovagnoli (ref3) 2006; 22 Y Song (ref20) 2015; 8 MA Smith (ref29) 1995; 18 HD Kim (ref21) 2007; 112 T Luck (ref5) 2015; 29 C Grossi (ref49) 2014; 13 F Panza (ref16) 2016; 2016 BR Wiseman (ref17) 1990; 16 LL Barnes (ref6) 2015; 211 T Myhrer (ref7) 1998; 23 PH Reddy (ref39) 2008; 14 P Marambaud (ref13) 2005; 280 JE Lee (ref32) 2013; 22 JL Holtzman (ref44) 2013; 13 M Yegambaram (ref4) 2015; 12 P.H St George-Hyslop (ref23) 2000; 924 A Cornejo (ref45) 2011; 27 AK Godbolt (ref2) 2004; 63 |
References_xml | – volume: 18 start-page: 172 year: 1995 ident: ref29 article-title: Radical AGEing in Alzheimer's disease publication-title: Trends Neurosci doi: 10.1016/0166-2236(95)93897-7 contributor: fullname: MA Smith – volume: 27 start-page: 417 year: 2002 ident: ref9 article-title: Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease publication-title: Neurochem Res doi: 10.1023/A:1015560116208 contributor: fullname: MA LaFontaine – volume: 21 start-page: 15 year: 1998 ident: ref33 article-title: Alzheimer's disease: a re-examination of the amyloid hypothesis publication-title: Trends Neurosci doi: 10.1016/S0166-2236(97)01168-5 contributor: fullname: RL Neve – volume: 25 start-page: 3032 year: 2005 ident: ref47 article-title: A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4225-04.2005 contributor: fullname: GP Lim – volume: 8 start-page: 1 year: 2015 ident: ref20 article-title: Protective effect of centipedegrass against Aβ oligomerization and Aβ-mediated cell death in PC12 cells publication-title: Pharm Biol contributor: fullname: Y Song – volume: 29 start-page: 382 year: 2015 ident: ref5 article-title: Association of the apolipoprotein E genotype with memory performance and executive functioning in cognitively intact elderly publication-title: Neuropsychology doi: 10.1037/neu0000147 contributor: fullname: T Luck – volume: 16 start-page: 2677 year: 1990 ident: ref17 article-title: Biochemical activity of centipedegrass against fall armyworm larvae publication-title: J Chem Ecol doi: 10.1007/BF00988078 contributor: fullname: BR Wiseman – volume: 94 start-page: 2095 year: 1997 ident: ref24 article-title: The Alzheimer family of diseases: Many etiologies, one pathogenesis? publication-title: Proc. Natl. Acad. Sci. U. S. A doi: 10.1073/pnas.94.6.2095 contributor: fullname: J Hardy – volume: 112 start-page: 30 year: 2007 ident: ref21 article-title: Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer’s disease publication-title: Immunol Lett doi: 10.1016/j.imlet.2007.06.006 contributor: fullname: HD Kim – volume: 41 start-page: 1781 year: 2006 ident: ref51 article-title: Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2006.08.015 contributor: fullname: F Longpré – volume: 22 start-page: 84 year: 2013 ident: ref32 article-title: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions publication-title: Exp Neurobiol doi: 10.5607/en.2013.22.2.84 contributor: fullname: JE Lee – volume: 6 start-page: e16564 year: 2011 ident: ref14 article-title: Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models publication-title: PLoS One doi: 10.1371/journal.pone.0016564 contributor: fullname: A Frydman-Marom – volume: 17 start-page: 649 year: 2002 ident: ref25 article-title: Very early-onset familial Alzheimer's disease: a novel presenilin 1 mutation publication-title: Int J Geriatr Psychiatry doi: 10.1002/gps.657 contributor: fullname: JS Goldman – volume: 24 start-page: 632 year: 2010 ident: ref37 article-title: Neuroprotective effect of luteolin on amyloid beta protein (25–35)-induced toxicity in cultured rat cortical neurons publication-title: Phytother Res doi: 10.1002/ptr.2940 contributor: fullname: HY Cheng – volume: 143 start-page: 597 year: 2013 ident: ref52 article-title: Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease publication-title: J Nutr doi: 10.3945/jn.112.169516 contributor: fullname: L Rojanathammanee – volume: 23 start-page: 199 year: 2010 ident: ref11 article-title: Five-year survival after Helicobacter pylori eradication in Alzheimer disease patients publication-title: Cogn Behav Neurol doi: 10.1097/WNN.0b013e3181df3034 contributor: fullname: J Kountouras – volume: 34 start-page: 115 year: 2013 ident: ref40 article-title: Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress publication-title: J Alzheimers Dis doi: 10.3233/JAD-121444 contributor: fullname: GL Caldeira – volume: 23 start-page: 131 year: 1998 ident: ref7 article-title: Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease publication-title: Neurosci Biobehav Rev doi: 10.1016/S0149-7634(98)00039-6 contributor: fullname: T Myhrer – volume: 4 start-page: 140 year: 2014 ident: ref15 article-title: Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer's Disease, and Cancer publication-title: J Tradit Complement Med doi: 10.4103/2225-4110.136540 contributor: fullname: R Hamidpour – volume: 94 start-page: 4526 year: 1997 ident: ref30 article-title: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease publication-title: Proc. Natl. Acad. Sci. U. S. A doi: 10.1073/pnas.94.9.4526 contributor: fullname: RE Davis – volume: 58 start-page: 399 year: 2011 ident: ref48 article-title: Silibinin: a novel inhibitor of Aβ aggregation publication-title: Neurochem Int doi: 10.1016/j.neuint.2010.12.017 contributor: fullname: F Yin – volume: 44 start-page: 591 year: 1992 ident: ref1 article-title: Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs publication-title: Am J Med Genet doi: 10.1002/ajmg.1320440512 contributor: fullname: H Karlinsky – volume: 6 start-page: 1 year: 2016 ident: ref12 article-title: Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer's disease patients publication-title: Expert Opin Emerg Drugs contributor: fullname: F Panza – volume: 14 start-page: 42 year: 2014 ident: ref55 article-title: Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications publication-title: Front Aging Neurosci contributor: fullname: J Wang – volume: 64 start-page: 183 year: 2001 ident: ref26 article-title: Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation publication-title: J Neurosci Res doi: 10.1002/jnr.1064 contributor: fullname: A Eckert – volume: 13 start-page: 131 year: 2014 ident: ref49 article-title: Employing Alzheimer disease animal models for translational research: focus on dietary components publication-title: Neurodegener Dis doi: 10.1159/000355461 contributor: fullname: C Grossi – volume: 162 start-page: 1232 year: 2009 ident: ref36 article-title: The anti-amnesic effects of luteolin against amyloid beta (25–35) peptide-induced toxicity in mice involve the protection of neurovascular unit publication-title: Neuroscience doi: 10.1016/j.neuroscience.2009.05.009 contributor: fullname: R Liu – volume: 94 start-page: 564 year: 2001 ident: ref53 article-title: Restriction fragment length polymorphism markers associated with silk maysin, antibiosis to corn earworm (Lepidoptera: Noctuidae) larvae, in a dent and sweet corn cross publication-title: J Econ Entomol doi: 10.1603/0022-0493-94.2.564 contributor: fullname: BZ Guo – volume: 22 start-page: 108 year: 2008 ident: ref19 article-title: Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays) publication-title: Phytother Res doi: 10.1002/ptr.2275 contributor: fullname: DA Farsi – volume: 136 start-page: 1383 year: 2013 ident: ref43 article-title: Brain amyloid-β oligomers in ageing and Alzheimer's disease publication-title: Brain doi: 10.1093/brain/awt062 contributor: fullname: SE Lesné – volume: 280 start-page: 37377 year: 2005 ident: ref13 article-title: Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides publication-title: J Biol Chem doi: 10.1074/jbc.M508246200 contributor: fullname: P Marambaud – volume: 12 start-page: 116 year: 2015 ident: ref4 article-title: Role of environmental contaminant in the etiology of Alzheimer's disease: a review publication-title: Curr Alzheimer Res doi: 10.2174/1567205012666150204121719 contributor: fullname: M Yegambaram – volume: 2016 start-page: 3245935 year: 2016 ident: ref16 article-title: Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease publication-title: Biomed Res Int doi: 10.1155/2016/3245935 contributor: fullname: F Panza – volume: 22 start-page: 238 year: 2006 ident: ref3 article-title: Cognitive deficits in familial Alzheimer's disease associated with M239V mutation of presenilin 2 publication-title: Dement Geriatr Cogn Disord doi: 10.1159/000094972 contributor: fullname: AR Giovagnoli – volume: 4 start-page: 193 year: 2002 ident: ref38 article-title: Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists publication-title: J Alzheimers Dis doi: 10.3233/JAD-2002-4309 contributor: fullname: DA Butterfield – volume: 211 start-page: 230 year: 2015 ident: ref6 article-title: Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals publication-title: J Infect Dis doi: 10.1093/infdis/jiu437 contributor: fullname: LL Barnes – volume: 95 start-page: 1303 year: 2002 ident: ref18 article-title: Effect of husk characters on resistance to corn earworm (Lepidoptera: Noctuidae) in high-maysin maize populations publication-title: J Econ Entomol doi: 10.1603/0022-0493-95.6.1303 contributor: fullname: BG Rector – volume: 14 start-page: 45 year: 2008 ident: ref39 article-title: Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease publication-title: Trends Mol Med doi: 10.1016/j.molmed.2007.12.002 contributor: fullname: PH Reddy – volume: 27 start-page: 143 year: 2011 ident: ref45 article-title: Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease publication-title: J Alzheimers Dis doi: 10.3233/JAD-2011-110623 contributor: fullname: A Cornejo – volume: 261 start-page: 921 year: 1993 ident: ref31 article-title: Gene dose of apolipoprotein E type 4 Allele and the risk of Alzheimer’s disease in late onset families publication-title: Science doi: 10.1126/science.8346443 contributor: fullname: EH Corder – volume: 175 start-page: 2557 year: 2009 ident: ref46 article-title: Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway publication-title: Am J Pathol doi: 10.2353/ajpath.2009.090417 contributor: fullname: T Hamaguchi – volume: 63 start-page: 1702 year: 2004 ident: ref2 article-title: A presenilin 1 R278I mutation presenting with language impairment publication-title: Neurology doi: 10.1212/01.WNL.0000143060.98164.1A contributor: fullname: AK Godbolt – volume: 398 start-page: 124 year: 2006 ident: ref34 article-title: Genetic study of Sardinian patients with Alzheimer's disease publication-title: Neurosci Lett doi: 10.1016/j.neulet.2005.12.063 contributor: fullname: P Piscopo – volume: 924 start-page: 1 year: 2000 ident: ref23 article-title: Genetic factors in the genesis of Alzheimer's disease publication-title: Ann. N. Y. Acad. Sci doi: 10.1111/j.1749-6632.2000.tb05552.x contributor: fullname: P.H St George-Hyslop – volume: 56 start-page: 780 year: 2010 ident: ref42 article-title: Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes publication-title: Neurochem Int doi: 10.1016/j.neuint.2010.02.017 contributor: fullname: PV Reddy – volume: 47 start-page: 382 year: 2014 ident: ref54 article-title: Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages publication-title: Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages contributor: fullname: J Lee – volume: 771 start-page: 147 year: 1997 ident: ref8 article-title: Abeta25-35 induces rapid lysis of red blood cells: contrast with Abeta1-42 and examination of underlying mechanisms publication-title: Brain Res doi: 10.1016/S0006-8993(97)00824-X contributor: fullname: MP Mattson – volume: 87 start-page: 245 year: 2014 ident: ref41 article-title: Genetics of Alzheimer's disease publication-title: Adv Genet doi: 10.1016/B978-0-12-800149-3.00005-6 contributor: fullname: V Chouraki – volume: 9 start-page: 88 year: 2007 ident: ref22 article-title: Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease publication-title: J Gene Med doi: 10.1002/jgm.993 contributor: fullname: HD Kim – volume: 12 start-page: 73 year: 2007 ident: ref27 article-title: Genetics of Alzheimer's disease. A rapidly evolving field publication-title: J Alzheimers Dis doi: 10.3233/JAD-2007-12108 contributor: fullname: A Serretti – volume: 33 start-page: 1372 year: 2002 ident: ref10 article-title: Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(02)01049-3 contributor: fullname: C Cecchi – volume: 17 start-page: 707 year: 1996 ident: ref28 article-title: Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system Neurobiol publication-title: Aging contributor: fullname: G.M Pasinetti – volume: 13 start-page: 59 year: 2013 ident: ref44 article-title: Cellular and animal models for high-throughput screening of therapeutic agents for the treatment of the diseases of the elderly in general and Alzheimer's disease in particular publication-title: Front Pharmacol contributor: fullname: JL Holtzman – volume: 37 start-page: 1354 year: 2014 ident: ref35 article-title: The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities publication-title: Arch Pharm Res doi: 10.1007/s12272-014-0351-3 contributor: fullname: JS Choi – volume: 1214 start-page: 177 year: 2008 ident: ref50 article-title: Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice publication-title: Brain Res doi: 10.1016/j.brainres.2008.02.107 contributor: fullname: K Rezai-Zadeh |
SSID | ssj0053866 |
Score | 2.3430245 |
Snippet | Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its... Alzheimer’s disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its... |
SourceID | plos doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | e0169509 |
SubjectTerms | Acetic acid Alanine Alanine transaminase Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - immunology Amyloid beta-Peptides - metabolism Amyloid beta-protein Animal models Animal tissues Animals Antibodies - immunology Aspartate aminotransferase Biology and Life Sciences Brain Brain - metabolism Brain - pathology Care and treatment Chromosomes Cytokines Cytokines - metabolism Dementia disorders Disease Models, Animal Enzyme-linked immunosorbent assay Epitopes Ethyl acetate Etiology Flavonoids Flavonoids - pharmacology Glucosides - pharmacology Helicoverpa zea Hippocampus Immune response Immune response (humoral) Immune system Immunofluorescence Immunoglobulin G Immunoglobulin M Infections Inflammation Interferon Interleukin 10 Interleukin 2 Interleukin 4 Liver Liver - drug effects Liver - metabolism Lymphocytes T Male Medicine and Health Sciences Metabolism Mice Mice, Transgenic Neurodegenerative diseases Neurotoxicity Older people Oxidative stress Pathogenesis Pathology Peptide Fragments - metabolism Plant Extracts - pharmacology Plaque, Amyloid - drug therapy Plaque, Amyloid - pathology Polyphenols Quantitation Quantitative analysis Research and Analysis Methods Rodents Senile plaques Staining Th2 Cells - immunology Th2 Cells - metabolism Toxicity Turfgrasses Veterinary colleges Veterinary medicine γ-Interferon |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fa9swEBYjT3sZ6341WzduMGgLc2vZsmQ_el1DO8gIawp9M5YsL6GuHWqnpfsb90ftznZCMgp72aslxbLuk_SdcveJsU-ZwG3BSNfx0ih1SAHLCT0VOYZ0aCNjAutSvvP4uzy7FN-ugquNq74oJqyTB-4G7ph7SuMqmoee5SIPtPZ8i5Mbt8GcWxOZdvXlwcqZ6tZgnMVS9olyvuLHvV2OFlVpj0h_JKAAxI2NqNXrX6_Kg0VR1Y9Rzr8jJze2otFz9qznkBB3fd9hT2z5gu30s7SGg15K-vAl-z1O0QwlpGUG500NoyK9q8pqnsFXRN5dK_oNlGECdMo7X9iMtCPqGuIGufSSeCjEN-jTY4tJkVI3QT8A3fdhKF4aEA2U4g_nlGZi4UcXcWuBjndhOvPg4tre2wxOHprqer5ZA3uF3BOmP-Egnkzqe_sZJhc8O40OIS5-zez8xt7u1zCulliZbmwrXrHL0en05Mzp729wDLpJjSOlq6QUNsylmyLTitDpFfgsF1rmaWCyIIy05q5BFpT6mQqQm2mfW4VuTsjz3H_NBiVabJeB4VaH2D6L_FQokYVKe26kAz8PcBtW-ZA5K2Mmi06mI2n_q1Po3nRWScj4SW_8IftCFl_XJZHt9gFCL-mhl_wLekO2T3hJaClANJi0z2jA95CoVhILpdrzB3zd3lZNnMJmq3iXELfqaZ2QQJcvkQ1LbLlC4ePFH9fF9KMUMVdatExC1yD4LlIUMWRvOtCuv5YUkNDV5kOmtuC8NRzbJeV81mqPI10XyGDf_o_xe8eeekSS2gOtPTZobpf2PVK8Rn9oZ_Mf8IdPVQ priority: 102 providerName: Directory of Open Access Journals – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtNAEF6V9MIF0fDTQEGDhEQr4cb_a5-QWxKlSKmiNkW9WbvrdRM1tUPstConXoOX4iF4EmYcJySo4urdjdeZmZ1vd2e-Yex94qJbUL5p2CIUBjFgGYHNQ0MRD22olKdNynfun_q9C_fLpXe5xXrLXBgKq1yuidVCneSKzsjbxFnk-AgQ_LaQdAqgyvan6TeD6kfRPWtdTOMR27Ytly5st486p4Oz5aqMdu37deqcw612LanDaZ7pQ2Ik8Sgkcc01VQz-q3W6MZ3kxUMg9N9YyjXn1H3KntSoEqKFGuywLZ012U5ttwXs1-TSB03W_ErxL1USLvTre_Vn7FdfoLgyEFkCJ2UB3Ym4zbN8nMBn7HxbkYMDZaIAnQaPpzohjomigKhEzD0nvArRDe79ccRgImjyIO-B6oIoiqsG1BqiAoATSkfRcLaIzNVAx8AwHNlwfq3vdALH92V-PV7vgbNCjArDK9iPBoPiTn-EwbmVdMIDiCbfR3p8o2e_f_wsoJ_PsTvVdps8ZxfdzvC4Z9SVHgyFG6rS8H2T-76rg9Q3BWKyELfHLj5LXemnwlOJF4RSWqZCvCSchHuI4qRjaY4bosBKU-cFa2QoyV0GytIywPFJ6AiXu0nApW2G0nNSDx02T1vMWAo5ni4IPeLqVo_jRmghrZiUIq6VosWOSBNWfYmOu3qQz67i2rpjy-YSXX0a2NpyU09K29HogRCrpZZWoWqxD6RHMS0apLqizn3A9xD9Vhy5nFcnFfi6vY2eaOxqo3mXNHE50yL-axY4cqmdDze_WzXTj1JsXaZRMjEVTHBMBDNui71cKPPqa4krCTflVovxDTXf-Ds2W7LxqGIpR2DvItZ99f9pvWaPbQJK1aHWHmuUs7l-gzCvlG9rC_4DUBxVsg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELem8sILYnytMNAhIQ0eUuXDsZMHhMqg2pCKELTS3iLbcdZqWVKadFD-Nf457tK0WlDhNbYTJ3eX-53t-x1jr1KObsEI1_FVrBxiwHIiX8aOIR7a2JjQupTvPP4szqb800V4ccC2NVvbD1jtDe2ontR0mQ9-fl-_Q4N_21RtkN520GBRFnZA7CIhZfTd8XnASefHfLevgNbd7F4SanGE7wZtMt2_7tJxVg2n_-7P3VvkZbUPlv59uvKWuxrdZ_danAnDjWIcsgNbPGCHrSVX8Lqlm37zkP0eKxRVAapI4byuYJSrm7Io5yl8QO28aYjBgbJQgFaC5wubEr9EVcGwRry9IqwKw2uM-3HEl1zRNEGvgWqCGDpTDagxRAMA55SKYuHr5lSuBVoChsnMh29X9odN4XRdl1fz2z1wVohPYXIJw_zXzM6v7fKkgnG5wjYq4pY_YtPRx8npmdOWdHAMRk61I4QrheA2yoSrEHzFGAdzvJZxLTIVmjSMYq091yAwUkEqQ4RrOvCsxMgn8rIseMx6BQroiIHxrI5wfBoHikueRlL7bqzDIAvRM8usz5yt7JLFhrkjabbvJEY8GyEkJOuklXWfvScB7_oS73ZzoVxeJq0ZJ54vNfr0LPKtx7NQaz-w6GoQlGWeNbHpsxNSj4T0FYVvVJvkgM8hnq1kyKVsliTwccednmjVptN8RAq2nWmVEGdXIBAgCxy5Vbr9zS93zXRTOkRXWJRMQpURAhdRC--zJxsd3b0tkSJh9O31mexob-dzdFuK-ayhI0cEzxHUPv3_Cz1jd31CRM3q1THr1cuVfY54rtYvGhP9A1CESeM priority: 102 providerName: Scholars Portal |
Title | Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer's Mouse Model |
URI | https://www.ncbi.nlm.nih.gov/pubmed/28072821 https://www.proquest.com/docview/1857360856/abstract/ https://search.proquest.com/docview/1868304134 https://pubmed.ncbi.nlm.nih.gov/PMC5224976 https://doaj.org/article/127b801f82e14f5bb23e467155f1ec9c http://dx.doi.org/10.1371/journal.pone.0169509 |
Volume | 12 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtpAEF4l9NJL1fQvpCmaSpWaSDX4f-2jQ6FJJSKUECk3y7teBytgIwyJ0lNfoy_Vh-iTdMbYKK5y6mUP3l28MDM73ywz3zL2KbbRLUhX18zIjzRiwNI8k_uaJB5aX0pH6VTvPDp3T6_s79fO9Q5z6lqYMmlfirSbzebdLJ2WuZWLuezVeWK98aiPmMFGN9rbZbvcsuoQfbP9ogG7blUjZ3GjV4mku8gz1SXqEfSQxADs6RyjDaPhjkrW_u3e3FrM8uIp4Plv_uQjhzR8yV5USBKCzYr32I7KXrG9ylYLOKoIpY9fs9-jCIWRQZTFcLYqYDiL7vIsT2P4ivp3V1J_A9WZAJ31pgsVE4NEUUCwQkS9JjQKwRwje5wxnkW0TBAPQLd-SMqaBtQJKvSHMyo2UXCxybtVQIe8MJmacHmr7lUM_YdVfps-HoGrQgQKkxs4Csbj4l59gfGlEQ_8YwhmP6Yqnavln5-_ChjlaxxON7fN3rCr4WDSP9Wqexw0ieHSSnNdnbuurbzE1SNEXD4GvzY-S2zhJpEjY8fzhTB0iWgosmLuIEYTlqE4hjuekSTWW9bKUHz7DKShhIfzY9-KbG7HHhem7gvHShx0xzxpM60WZ7jY0HWE5X92HMOcjVxC0oSw0oQ2OyGZb8cS2Xb5IF_ehJXKhYbJBTryxDOVYSeOEKal0L8gEksMJX3ZZp9JY0LaElAfZFRVNuB7iFwrDGzOy3MIfN1hYySasmx075PO1SstQiLqslxExS7OrPXw6e6P2276UMqcyxRKJqTrECwdoYrdZu82arv9trURtBlvKHTj52j2oEmWHOSVCR7898z37LlJCKk8zTpkrdVyrT4gvluJDlr1NcfW6xvUDr912LOTwfn4olOemGA7sr1OafV_ATlyV_c |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,12083,12250,12792,21416,24346,27957,27958,31754,31755,33301,33302,33408,33409,33779,33780,43345,43614,43635,43840,53827,53829,74102,74371,74392,74659 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtNAEF5BOMClouGngQKDhEQr4dY_a699QqY0SqGpIpqi3Cx7vW6ipnaInVblxGvwUjwET8KMswkJqrh6d-N1Zmbnm92Zbxl7k3J0C9IzDTsOYoMYsAzfFoEhiYc2kNJVJtU7d0-8zhn_NHAHesOt1GmVizWxXqjTQtIe-T5xFjkeAgTv_eSbQbdG0emqvkLjLrvHHYdTSp8YLAMutGXP0-VyjrD2tXT2JkWu9oiFxKU0xBV3VLP2L9fmxmRclLcBz3_zJ1ccUvsh29BIEsK56DfZHZU32aa21RJ2NKH0bpM1v1LOS114C119lv6I_erGKKIc4jyFo6qE9ji-KvJilMJH7HxVE4IDVZ8A7QCPJiolXomyhLBCnD0jjArhJcb7OKI3jmnykNwA3QUiKZcaUFOo_B-OqARFwZd5Nq4C2vqF_tCG0wt1rVI4uKmKi9FqD5wV4lLon8NO2OuV1-od9E6t9DDYhXD8fahGl2r6-8fPErrFDLvTfW7jx-ysfdg_6Bj6dgdDYhBVGZ5nCs_jys88M0YcFmBIzPFZxhMvi12Zun6QJJYpESPFTipcRG6JYymBQZBvZZnzhDVylOQWA2mpxMfxaeDEXPDUF4ltBonrZC46aZG1mLEQcjSZk3hE9UmewOBnLq2IlCLSStFiH0gTln2Jgrt-UEzPI23RkWWLBN175tvK4pmbJLaj0OsgPsssJQPZYm9JjyJaKFBLZKzrHfA9RLkVhVyIencCX7e91hMNXK41b5EmLmZaRn9NAUcutPP25tfLZvpRyqfLFUomoksSHBMBDG-xp3NlXn4t8SNhIG61mFhT87W_Y70lHw1rZnIE8xzx7bP_T-sVu9_pd4-j46OTz8_ZA5uAUr2ptc0a1XSmXiDMq5KXtS3_ARDHU38 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1fb9MwELegkxAviJU_Kww4JCQ2iaz5aydPqNtabUCrauvQ3qLEcdZqXVKadNN44mvwpfgQfBLuUre0aOI1thund2f_zr77HWPvEhe3BclNw46CyCAGLMO3RWBI4qENpPSUSfnO3R4_OnM_nXvnOv6p0GGVizWxWqiTXNIZeZM4ixyOAIE3Ux0W0T_sfJx8M6iCFN206nIa99mGcLmHGr6x3-71TxbrMlo25zp5zhFWU8tqb5Jnao84STwKSlzZnCoO_-VKXZuM8-IuGPpvNOXK9tR5zB5pXAmtuSJssnsqq7NNbbkF7Gh66d06q3-lCJgqDRe6-mb9CfvVjVBgGURZAsdlAZ1xdJ1n-SiBQ-x8XdGDA-WiAJ0HjyYqIZaJooBWiah7RogVWlfo_eOI_jiiyUN8C1QZRFJkNaDeEBkAHFNCioKTeWyuAjoIhsHQhtNLdaMSOLgt88vRag-cFaJUGFzATqvfL27UB-ifWkk72IXW-PtQja7U9PePnwV08xl2p-pu46fsrNMeHBwZutaDIdGlKg3OTcG5q_yUmxGisgAdZBefpW7M08iTiecHcWyZEhFT5CTCQxwXO5YS6BL5Vpo6z1gtQ0luMZCWin0cnwRO5Ao38UVsm0HsOamHW7ZIG8xYCDmczCk9wupeT6ArNJdWSEoRaqVosH3ShGVfIuSuHuTTi1Dbd2jZIsbNPvVtZbmpF8e2o3APQrSWWkoGssHekx6FtGyglshIZz_ge4iAK2y5QlRnFfi67bWeaO5yrXmLNHEx0yL8axg4cqGddze_XTbTj1J0XaZQMiGVTHBMhDNugz2fK_Pya4ktCd1yq8HEmpqv_R3rLdloWPGUI7R3Ee2--P-03rAHaMjhl-Pe55fsoU2oqTrh2ma1cjpTrxDzlfFrbcx_AM44WSI |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Maysin+and+Its+Flavonoid+Derivative+from+Centipedegrass+Attenuates+Amyloid+Plaques+by+Inducting+Humoral+Immune+Response+with+Th2+Skewed+Cytokine+Response+in+the+Tg+Alzheimer%27s+Mouse+Model&rft.jtitle=PloS+one&rft.au=Song%2C+Yuno&rft.au=Kim%2C+Hong-Duck&rft.au=Lee%2C+Min-Kwon&rft.au=Hong%2C+Il-Hwa&rft.date=2017-01-01&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=12&rft.issue=1&rft.spage=e0169509&rft_id=info:doi/10.1371%2Fjournal.pone.0169509&rft.externalDocID=A477004699 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |