The role of necroptosis in cancer biology and therapy

• Published in: Molecular cancer Vol. 18; no. 1; pp. 100 - 17
• Main Authors: Gong, Yitao, Fan, Zhiyao, Luo, Guopei, Yang, Chao, Huang, Qiuyi, Fan, Kun, Cheng, He, Jin, Kaizhou, Ni, Quanxing, Yu, Xianjun, Liu, Chen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.05.2019; BioMed Central; BMC
• Subjects: Adaptive immunity; Antitumor activity; Apoptosis; Autophagy; Biology; Cancer; Cancer therapies; Care and treatment; Caspase; Cell death; Chemotherapy; Disease Progression; Drug delivery; Drug development; Drug resistance; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Immune response; Immunosuppressive agents; Inflammation; Kinases; Ligands; Liver cancer; MAP kinase; Metastases; Metastasis; Microenvironments; Mixed lineage kinase domain-like pseudokinase (MLKL); Necroptosis; Neoplasms - immunology; Neoplasms - metabolism; Protein Kinases - metabolism; Proteins; Receptor-interacting protein kinase (RIPK); Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; Review; T cell receptors; Tumor Microenvironment; Tumor necrosis factor-TNF; Tumorigenesis; Immunosuppression; Receptor-interacting protein kinase (RIPK); Mixed lineage kinase domain-like pseudokinase (MLKL); Necroptosis; Therapeutics; Metastasis; Autophagy; Apoptosis
• ISSN: 1476-4598; 1476-4598
• DOI: 10.1186/s12943-019-1029-8

Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem. Necroptosis is a regulated necrotic cell death modality...