Conformational biosensors reveal GPCR signalling from endosomes - Irannejad, Roshanak; Tomshine, Jin C.; Tomshine, Jon R.; Chevalier, Michael; Mahoney, Jacob P.; Steyaert, Jan; Rasmussen, Søren G. F.; Sunahara, Roger K.; El-Samad, Hana; Huang, Bo; von Zastrow, Mark (Nature (London), 2013)
Keywords: 631/80/86/2363; Adrenergic beta-2 Receptor Agonists - pharmacology; Biosensing Techniques - methods; Biosensors; Cell Membrane - chemistry; Cell Membrane - metabolism; Clathrin-Coated Vesicles; Cyclic AMP - metabolism; Cytoplasm; Dopamine; Endocytosis; Endosomes - chemistry; Endosomes - metabolism; Green Fluorescent Proteins - analysis; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; GTP-Binding Protein alpha Subunits, Gs - metabolism; HEK293 Cells; Humanities and Social Sciences; Humans; Hypotheses; Isoproterenol - pharmacology; letter; Ligands (Biochemistry); Models, Biological; multidisciplinary; Pharmacology; Phosphorylation; Plasma; Protein Conformation; Proteins; Receptors, Adrenergic, beta-2 - chemistry; Receptors, Adrenergic, beta-2 - immunology; Receptors, Adrenergic, beta-2 - metabolism; Recruitment; Science; Signal Transduction; Single-Domain Antibodies - genetics; Single-Domain Antibodies - immunology; United States