Dopamine, cognitive function, and gamma oscillations: role of D4 receptors

• Published in: Frontiers in cellular neuroscience Vol. 7; p. 102
• Main Authors: Furth, Katrina E., Mastwal, Surjeet, Wang, Kuan H., Buonanno, Andres, Vullhorst, Detlef
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2013; Frontiers Media S.A
• Subjects: ADHD; Antipsychotics; Attention deficit hyperactivity disorder; Cognitive ability; Dopamine; Dopamine D4 receptors; ErbB-2 protein; gamma oscillations; Hallucinations; Hyperactivity; Interneurons; Memory; Mental disorders; Musical performances; Neuregulin; Neurons; Neuroscience; Neurosciences; Oscillations; Parvalbumin; Prefrontal Cortex; Psychotropic drugs; Receptor mechanisms; Risk factors; Schizophrenia; Signal transduction; Synergism; United States > US; ADHD; fast-spiking interneurons; parvalbumin; prefrontal cortex; gamma oscillations; D4 receptor; schizophrenia; dopamine

Cognitive deficits in individuals with schizophrenia (SCZ) are considered core symptoms of this disorder, and can manifest at the prodromal stage. Antipsychotics ameliorate positive symptoms but only modestly improve cognitive symptoms. The lack of treatments that improve cognitive abilities current...