A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma

• Published in: Journal of translational medicine Vol. 17; no. 1; pp. 50 - 13
• Main Authors: Liu, Xiao-Xia, Yang, Yi-E, Liu, Xiao, Zhang, Meng-Yu, Li, Rui, Yin, Yun-Hong, Qu, Yi-Qing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.02.2019; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - diagnosis; Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - pathology; Adenocarcinoma of Lung - surgery; Binding sites; Biochemistry; Bioinformatics; Biological markers; Biomarker; Biomarkers; Biomarkers - metabolism; Cancer genetics; Cancer therapies; Case-Control Studies; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Cholecystokinin; CircRNA; Circular RNA; Computational biology; Computer programs; Datasets; Diagnosis; Epidermal growth factor receptors; Female; Future predictions; Gene expression; Gene Expression Regulation, Neoplastic; Gene Ontology; Gene Regulatory Networks; Genes; Genetic research; Genomes; Genomics; Hsa_circ_0005962; Humans; Kinases; Liver cancer; LUAD; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Messenger RNA; MicroRNA; MicroRNAs; Middle Aged; miRNA; Mutation; Plasma; Polymerase chain reaction; Reproducibility of Results; RNA; RNA, Circular - blood; RNA, Circular - genetics; ROC Curve; Surgery; Plasma; Biomarker; Hsa_circ_0086414; Diagnosis; CircRNA; Hsa_circ_0005962; LUAD

Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed to evaluate whether circulating circRNAs could be used as diagnostic biomarkers for lung adenocarcinoma (LUAD). The Gene Expression Omnibus (GEO) dataset was...