GPR120 is an important inflammatory regulator in the development of osteoarthritis

• Published in: Arthritis research & therapy Vol. 20; no. 1; pp. 163 - 11
• Main Authors: Chen, Yuanfeng, Zhang, Dan, Ho, Ki Wai, Lin, Sien, Suen, Wade Chun-Wai, Zhang, Huantian, Zha, Zhengang, Li, Gang, Leung, Po Sing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.08.2018; BioMed Central; BMC
• Subjects: Adipocytes; Arthritis; Biomarkers; Care and treatment; Cartilage; Cell receptors; Defects; Development and progression; Diabetes; Fatty acids; G-protein coupled receptors; Gene expression; Genetic aspects; Health aspects; Homeostasis; Lipids; Lubricants & lubrication; Metabolism; Nutrition research; Obesity; Osteoarthritis; Polyunsaturated fatty acids; Powell, Jerome; Proinflammatory mediators; Proteins; Rodents; Skin; Skin defect; Stem cells; Subchondral bone; Tumor necrosis factor-TNF; Weight control; United States > US; Cartilage; Proinflammatory mediators; Skin defect; G-protein coupled receptors; Diagnostic markers; Polyunsaturated fatty acids; Subchondral bone

The aim of this study was to investigate the regulatory role of G-protein coupled receptor 120 (GPR120) in the development and progression of osteoarthritis (OA). GPR120 knockout (KO) and wild-type (WT) mice were used to create an animal model of OA by means of anterior cruciate ligament transection...