Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome

• Published in: Scientific reports Vol. 10; no. 1; p. 593
• Main Authors: Sundin, Johanna, Aziz, Imran, Nordlander, Sofia, Polster, Annikka, Hu, Yue O. O., Hugerth, Luisa W., Pennhag, Alexandra A. L., Engstrand, Lars, Törnblom, Hans, Simrén, Magnus, Öhman, Lena
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.01.2020; Nature Publishing Group
• Subjects: 38/47; 38/61; 45/22; 45/61; 631/326/2565/107; 692/4020/1503/2745; Adult; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - growth & development; Breath Tests; Case-Control Studies; Clinical Medicine; Colon; Duodenum; Dysbiosis - diagnosis; Fecal microflora; Feces; Feces - microbiology; Female; Gastrointestinal tract; Gene expression; Humanities and Social Sciences; Humans; hydrogen; Immune response; intestinal bacterial overgrowth; Intestine; Intestine, Small - microbiology; Irritable bowel syndrome; Irritable Bowel Syndrome - microbiology; Klinisk medicin; Lactulose; Male; Microbiology; Microbiota; Mikrobiologi; Mucosa; Mucous Membrane - microbiology; multidisciplinary; Phylogeny; RNA, Bacterial - genetics; RNA, Ribosomal, 16S - genetics; rRNA 16S; Science; Science & Technology - Other Topics; Science (multidisciplinary); Sequence Analysis, DNA - methods; Severity of Illness Index; temporal stability; Young Adult

Altered bacterial composition and small intestinal bacterial overgrowth (SIBO) may be associated with irritable bowel syndrome (IBS). This study aimed to determine the fecal and mucosa-associated bacterial composition along the gastrointestinal (GI) tract and to assess SIBO in IBS. Bacterial composi...