The role of collagen in cancer: from bench to bedside

• Published in: Journal of translational medicine Vol. 17; no. 1; pp. 309 - 22
• Main Authors: Xu, Shuaishuai, Xu, Huaxiang, Wang, Wenquan, Li, Shuo, Li, Hao, Li, Tianjiao, Zhang, Wuhu, Yu, Xianjun, Liu, Liang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.09.2019; BioMed Central; BMC
• Subjects: Cancer; Cellular signal transduction; Collagen; Exosomes; Extracellular matrix; Fibroblasts; Fibronectin; Fibrosis; Genetic aspects; Health aspects; Hyaluronic acid; Hypoxia; Integrins; Laminin; Lymphocytes; Macrophages; Matrix metalloproteinase; miRNA; Mutated genes; Nanoparticles; Oncology, Experimental; Prognosis; Protein-tyrosine kinase; Review; Signal transduction; Signaling pathways; Transcription factors; Tumor microenvironment; China; Mutated genes; Resistance; Signaling pathways; Therapy; Prognosis; Tumor microenvironment; Collagen; Cancer

Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through in...