Contribution of the inflammasome to inflammaging

• Published in: Journal of inflammation (London, England) Vol. 15; no. 1; pp. 23 - 10
• Main Authors: Mejias, Nancy H., Martinez, Camila C., Stephens, Marisa E., de Rivero Vaccari, Juan Pablo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.11.2018; BioMed Central; BMC
• Subjects: Aging; Analysis; Animal cognition; Apoptosis; ASC; Brain research; Caspase; Caspase-1; Caspase-11; Cell death; Chronic illnesses; Cortex; Cytokines; Cytosol; Dehydrogenases; Disease; Ethnicity; Fibroblasts; Hippocampus; Hispanic people; IL-1β; Immune response; Inflammasome; Inflammasomes; Inflammation; Innate immunity; Interleukin 18; Lactose; Lysates; Mammals; Mitochondria; Mitochondrial DNA; Older people; Oligomerization; Oxidative stress; Postpositivism; Proteins; Pyroptosis; Socioeconomic factors; Studies; White people; ASC; Oxidative stress; Aging; Inflammaging; Inflammasome; Inflammation; Caspase-1

Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer's disease and Parkinson's disease. The inflammasome is a multi-protein complex of th...