Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke - Chen, Shuang; Dong, Zhiping; Cheng, Man; Zhao, Yaqian; Wang, Mengying; Sai, Na; Wang, Xuan; Liu, Huan; Huang, Guowei; Zhang, Xumei (Journal of neuroinflammation, 2017)
Keywords: Alzheimer's disease; Analysis; Animals; Brain; Brain injury; Brain Ischemia - metabolism; Brain Ischemia - pathology; Carotid arteries; Cell activation; Chlorides; Cytokines; Dentate gyrus; Development and progression; Gene expression; Genetic aspects; Homocysteine; Homocysteine - metabolism; Immunohistochemistry; Inflammation; Inflammation - metabolism; Inflammation - pathology; Interleukin 6; Ischemia; Ischemic brain; Janus kinase 2; Male; Microglia; Microglia - metabolism; Microglial cell; Microglial cells; Nervous system; Neural networks; Neurotoxicity; Phosphorylation; Physiological aspects; Rats; Rats, Sprague-Dawley; Reperfusion; Risk factors; Rodents; Signal transducers and activators of transcription 3; Signal transduction; Signal Transduction - physiology; Stat3 protein; STAT3 Transcription Factor - metabolism; Stroke; Stroke - metabolism; Stroke - pathology; Toxicity; Transcription; Triphenyltetrazolium chloride; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Veins & arteries; China; Microglial cell; Inflammation; Signal transducers and activators of transcription 3; Ischemic brain; Homocysteine