Chronic exposure to mono-(2-ethylhexyl)-phthalate causes endocrine disruption and reproductive dysfunction in zebrafish

• Published in: Environmental toxicology and chemistry Vol. 35; no. 8; pp. 2117 - 2124
• Main Authors: Zhu, Yongtong, Hua, Rui, Zhou, Yao, Li, Hong, Quan, Song, Yu, Yanhong
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2016
• Subjects: abnormal development; animal ovaries; Animal reproduction; Animals; Aquatic environment; chronic exposure; Danio rerio; Diethylhexyl Phthalate - analogs & derivatives; Diethylhexyl Phthalate - toxicity; Dose-Response Relationship, Drug; Egg production; egg shell; eggs; Embryology; Embryos; Endocrine disruption; Endocrine disruptors; Endocrine Disruptors - toxicity; Esters; estradiol; Estradiol - blood; Exposure; Female; females; fish; Gene Expression - drug effects; gene expression regulation; genes; Gonadal Steroid Hormones - blood; Hatching; Male; males; Mono-(2-ethylhexyl)-phthalate (MEHP); Offspring; Ovary - drug effects; Phthalates; progeny; protein content; Reproduction; Reproduction - drug effects; Sex hormones; spermatozoa; steroidogenesis; testes; Testis - drug effects; testosterone; Testosterone - analogs & derivatives; Testosterone - blood; Toxicology; transcription (genetics); Up-Regulation; vitellogenin; Vitellogenins - blood; Water Pollutants, Chemical - toxicity; Water pollution; Zebrafish; Zebrafish - growth & development; Zebrafish - metabolism; Endocrine disruption; Sex hormones; Zebrafish; Reproduction; Mono-(2-ethylhexyl)-phthalate (MEHP)

Phthalic acid esters are frequently detected in aquatic environments. In the present study, zebrafish were exposed to low concentrations (0 µg/L, 0.46 µg/L, 4.0 µg/L, and 37.5 µg/L) of mono‐(2‐ethylhexyl) phthalate (MEHP) for 81 d, and the effects on reproduction, gamete quality, plasma vitellogenin...