Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma

• Published in: Cancer science Vol. 94; no. 3; pp. 308 - 313
• Main Authors: Ito, Akira, Tanaka, Kouji, Kondo, Kazuyoshi, Shinkai, Masashige, Honda, Hiroyuki, Matsumoto, Kazuhiko, Saida, Toshiaki, Kobayashi, Takeshi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2003; Blackwell; John Wiley & Sons, Inc
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Colony-stimulating factor; Combined Modality Therapy; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use; HSP70 Heat-Shock Proteins - analysis; Hyperthermia; Hyperthermia, Induced; Immunotherapy; Immunotherapy - methods; Interleukin-2 - therapeutic use; Leukocytes (granulocytic); Liposomes; Macrophages; Magnetic fields; Magnetics; Magnetite; Medical sciences; Melanoma; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; Melanoma, Experimental - therapy; Mice; Mice, Inbred C57BL; Nanoparticles; Nodules; Pharmacology. Drug treatments; Recombinant Proteins; Surface charge; Survival; Time Factors; Tumor Cells, Cultured; Tumors; Antineoplastic agent; Nanoparticle; Spontaneous; Cytokine; Rodentia; Liposome; Malignant tumor; Vertebrata; Mammalia; Magnetic; Interleukin 2; Mouse; Polypeptide; Animal; Immunotherapy; B16-Melanoma; Established cell line; Combined treatment; Granulocyte macrophage colony stimulating factor; Induced hyperthermia

Immunotherapy (IT) has become an accepted therapeutic modality. We previously reported that intracellular hyperthermia (IH) using magnetic nanoparticles induces antitumor immunity. We undertook these studies in order to study the combined effects of IT and IH on melanoma. Magnetite cationic liposome...