Rapid Electrophilic 211 At-Astatination of Trimethylgermyl Arenes

• Published in: ChemPlusChem (Weinheim, Germany) Vol. 89; no. 9; p. e202400254
• Main Authors: Müller, Marius, Battisti, Umberto Maria, Zabrocki, Merlin, Hansson, Ellinor, Jensen, Holger, Aneheim, Emma, Lindegren, Sture, Herth, Matthias Manfred
• Format: Journal Article
• Language: English
• Published: Germany 05.09.2024
• Subjects: Electrophilic Aromatic Substitution; Trifluoro Acetic Acid; Astatine-211; Radiopharmaceuticals; Trimethylgermyl Arenes

A set of At-astatoarenes were synthesized from corresponding trimethylgermyl arenes with an average radiochemical conversion (RCC) of ca. 50 % for electron-rich and approx. 70 % in case of electron-deficient arenes. Both electron rich and electron poor substrates were successfully radiolabeled at ro...