Roles of host and viral microRNAs in human cytomegalovirus biology

• Published in: Virus research Vol. 157; no. 2; pp. 180 - 192
• Main Authors: Dhuruvasan, Kavitha, Sivasubramanian, Geetha, Pellett, Philip E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2011
• Subjects: biogenesis; biology; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus - metabolism; Cytomegalovirus Infections - genetics; Cytomegalovirus Infections - metabolism; Gene Expression Regulation; genes; Genome, Viral; genomes; Herpesvirus; Host-Pathogen Interactions; Human betaherpesvirus 5; Human cytomegalovirus; Human herpesvirus 5; Humans; immunomodulators; infection; Mammalian target of rapamycin; mechanism of action; MicroRNA; MicroRNAs - metabolism; plants (botany); Virus Latency; virus replication; viruses; Cytomegalovirus; MicroRNA; Human herpesvirus 5; Mammalian target of rapamycin; Herpesvirus; Human cytomegalovirus

Human cytomegalovirus (HCMV) has a relatively large and complex genome, a protracted lytic replication cycle, and employs a strategy of replicational latency as part of its lifelong persistence in the infected host. An important form of gene regulation in plants and animals revolves around a type of...