Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages

• Published in: Stem cell research & therapy Vol. 11; no. 1; pp. 39 - 15
• Main Authors: Zhang, Shichang, Chen, Li, Zhang, Guoying, Zhang, Bo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.01.2020; BioMed Central; BMC
• Subjects: Amputation; Angiogenesis; Animals; Antibodies; Chemotaxis; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - genetics; Diabetes therapy; Endothelial cells; Endothelial Cells - metabolism; Endothelial growth factors; Endothelium; Experiments; Female; Fetal Blood - metabolism; Inflammation; Interleukin 6; Interleukins; Laboratory animals; Leukocyte migration; Lipopolysaccharides; Macrophage Activation - genetics; Macrophages; Mesenchyme; Mice; Microscopy; Mitogens; Necrosis; Phenotypes; Plastic surgery; Prostaglandin E2; Prostaglandins; Prostaglandins E; Skin; Skin - physiopathology; Stem cell transplantation; Stem cells; Stem Cells - metabolism; Streptozocin; Surgery; Tumor necrosis factor-α; Tumors; Ulcers; Umbilical cord; Umbilical cord-derived matrix stem cells; Vascular endothelial cells; Vascular endothelial growth factor; Wound care; Wound healing; Wound Healing - genetics; Canada; Japan; United States > US; Vascular endothelial cells; Wound healing; Macrophages; Umbilical cord-derived matrix stem cells; Diabetes mellitus

Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diabetic wound healing; however, the underlying mechanism remains unclear. Here, we explored th...