Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly
Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10 11 cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2)....
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| Published in | Bioscience, biotechnology, and biochemistry Vol. 74; no. 5; pp. 939 - 945 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Tokyo
Japan Society for Bioscience, Biotechnology, and Agrochemistry
2010
Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press |
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| Abstract | Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10
11
cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. |
|---|---|
| AbstractList | Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre- administered a test food containing 1x10 super(11) cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10 11 cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre-administered a test food containing 1x10(11) cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity.Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre-administered a test food containing 1x10(11) cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre-administered a test food containing 1x10(11) cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×1011 cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10¹¹ cfu of BB536 daily for 5 weeks (P1), during which they also received influenza vaccination at week 3. The subjects were then randomized to a BB536 group and a placebo group for 14 weeks (P2). The proportion of subjects who contracted influenza was significantly lower in BB536 group than in the to placebo group. The proportion of subjects with fever was also significantly lower in the BB536 group than in the placebo group. In the P1 period, the NK cell activity and the bactericidal activity of the neutrophils were significantly higher at week 5 than to before BB536 administration. In the P2 period, although NK cell activity and neutrophilic activities declined at the end of the study in both the placebo and the BB536 group, neutrophil phagocytic activity and NK cell activity tended to maintain slightly higher levels in the BB536 group than in the placebo group. These results suggest that continuous ingestion of BB536 reduces the incidence of influenza and fever, probably by potentiating innate immunity. |
| Author | Suzuki, K Hatano, M Yaeshima, T Namba, K., Morinaga Milk Industry Co. Ltd., Zama, Kanagawa (Japan). Nutritional Science Lab Takase, M |
| Author_xml | – sequence: 1 fullname: Namba, K., Morinaga Milk Industry Co. Ltd., Zama, Kanagawa (Japan). Nutritional Science Lab – sequence: 2 fullname: Hatano, M – sequence: 3 fullname: Yaeshima, T – sequence: 4 fullname: Takase, M – sequence: 5 fullname: Suzuki, K |
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| Cites_doi | 10.1016/S0198-8859(02)00748-6 10.1023/A:1010979225018 10.1016/j.coi.2004.11.001 10.1111/j.1447-0594.2004.00261.x 10.18388/abp.2000_4010 10.1111/j.1348-0421.2007.tb03953.x 10.1271/bbb.64.2706 10.1002/ibd.20861 10.1038/sj.ejcn.1601093 10.1248/bpb.18.148 10.1271/bbb.60260 10.1093/ajcn/74.6.833 10.1046/j.1442-2042.2001.00392.x 10.1016/j.ypmed.2004.07.019 10.1159/000213305 10.1111/j.1365-2567.2004.01849.x 10.1002/mrm.20777 10.1146/annurev.immunol.17.1.189 10.1111/j.1365-2249.2006.03111.x 10.1159/000052813 10.1128/CDLI.6.2.186-192.1999 10.1038/sj.ejcn.1600938 |
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| Keywords | Human Lactic acid bacteria Actinomycetaceae Antibody Bifidobacterium longum Cellular immunity Vaccine Actinomycetales Infection Natural killer cell innate immunity Viral disease Influenza NK cell Bacteria Actinomycetes Neutrophil Elderly neutrophils |
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| Snippet | Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10
11
cfu of BB536 daily for 5 weeks (P1), during which... Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre-administered a test food containing 1x10(11) cfu of BB536 daily for 5 weeks (P1), during... Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×1011 cfu of BB536 daily for 5 weeks (P1), during which... Twenty-seven elderly subjects (mean age 86.7±6.6 years) were pre-administered a test food containing 1×10¹¹ cfu of BB536 daily for 5 weeks (P1), during which... Twenty-seven elderly subjects (mean age 86.7+/-6.6 years) were pre- administered a test food containing 1x10 super(11) cfu of BB536 daily for 5 weeks (P1),... |
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| SubjectTerms | ADMINISTRACION ADMINISTRATION Aged, 80 and over Anti-Bacterial Agents - therapeutic use antibacterial properties ANTIBODIES Antibodies, Viral - immunology ANTICORPS ANTICUERPOS BIFIDOBACTERIUM Bifidobacterium - immunology Bifidobacterium longum Biological and medical sciences biotechnology Blood Bactericidal Activity cell-mediated immunity CELLS CELLULE CELULAS ELDERLY Female fever Fever - complications Fundamental and applied biological sciences. Psychology Hematologic Tests http://www.fao.org/aos/agrovoc#c_130 http://www.fao.org/aos/agrovoc#c_1418 http://www.fao.org/aos/agrovoc#c_23898 http://www.fao.org/aos/agrovoc#c_28629 http://www.fao.org/aos/agrovoc#c_3799 http://www.fao.org/aos/agrovoc#c_3802 http://www.fao.org/aos/agrovoc#c_3852 http://www.fao.org/aos/agrovoc#c_3859 http://www.fao.org/aos/agrovoc#c_493 http://www.fao.org/aos/agrovoc#c_8130 Humans IMMUNE RESPONSE IMMUNITE IMMUNITY Immunity, Cellular - immunology INFECCION INFECTION influenza influenza vaccination influenza vaccines Influenza Vaccines - immunology Influenza, Human - drug therapy Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - microbiology INFLUENZAVIRUS ingestion INMUNIDAD innate immunity Killer Cells, Natural - immunology Male neutrophils Neutrophils - immunology NK cell PERSONNE AGEE phagocytosis placebos REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA TERCERA EDAD test meals VACCIN VACCINES VACUNA |
| Title | Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly |
| URI | https://www.tandfonline.com/doi/abs/10.1271/bbb.90749 https://www.ncbi.nlm.nih.gov/pubmed/20460726 https://www.proquest.com/docview/1449844326 https://www.proquest.com/docview/2524279235 https://www.proquest.com/docview/733105559 https://www.proquest.com/docview/762278893 |
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