Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

• Published in: BMC cancer Vol. 19; no. 1; pp. 271 - 9
• Main Authors: Zhu, Yuanhang, Ren, Chenchen, Yang, Li, Zhang, Xiaoan, Liu, Ling, Wang, Zhaoxin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.03.2019; BioMed Central; BMC
• Subjects: Accuracy; Adult; Aged; Analysis; ASCUS; Atypical Squamous Cells of the Cervix - metabolism; Atypical Squamous Cells of the Cervix - virology; Biomarkers; Care and treatment; Cellular biology; Cervical cancer; Cervix dysplasia; CIN; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cytology; Deoxyribonucleic acid; Diagnosis; DNA; DNA, Viral - genetics; Dysplasia; E6/E7; Early Diagnosis; Female; Genetic testing; Histochemistry; HPV; Human papillomavirus; Humans; Immunocytochemistry; Immunohistochemistry; Infections; Ki-67 Antigen - metabolism; Medical screening; Messenger RNA; Middle Aged; mRNA; Oncogene Proteins, Viral - genetics; p16/Ki67; Papillomaviridae - genetics; Papillomaviridae - metabolism; Papillomavirus infections; Papillomavirus Infections - diagnosis; Papillomavirus Infections - metabolism; Papillomavirus Infections - virology; Population; RNA; Sensitivity and Specificity; Stains & staining; Systematic review; Triage; Uterine Cervical Dysplasia - diagnosis; Uterine Cervical Dysplasia - metabolism; Uterine Cervical Dysplasia - virology; Women; Women's health; Womens health; Young Adult; United States > US; China; CIN; mRNA; ASCUS; E6/E7; p16/Ki67; HPV

Atypical squamous cell of undetermined significance (ASCUS) is a common cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients, but its lower specificity brings a series of problems. The purpose of this study was to evaluated the value of p16/Ki67 immunostaining,...