Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

• Published in: BMC cancer Vol. 18; no. 1; pp. 723 - 7
• Main Authors: Platais, Christopher, Radhakrishnan, Raghu, Niklander Ebensperger, Sven, Morgan, Richard, Lambert, Daniel W., Hunter, Keith D.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.07.2018; BioMed Central; BMC
• Subjects: Aged; Aged, 80 and over; Analysis; Apoptosis; Apoptosis - drug effects; Breast cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Cell culture; Comparative analysis; Female; Gene expression; Genetic aspects; Homeodomain Proteins - antagonists & inhibitors; Homeodomain Proteins - physiology; HOX genes; Humans; HXR9; Intercellular Signaling Peptides and Proteins; Investigations; Keratinocytes; Keratinocytes - drug effects; Kinases; Liver cancer; Lung cancer; Male; Middle Aged; Mouth Neoplasms - drug therapy; Mouth Neoplasms - pathology; Oral Cancer; OSCC; Ovarian cancer; PBX; Peptides; Peptides - therapeutic use; Phenotypes; Pre-B-Cell Leukemia Transcription Factor 1 - antagonists & inhibitors; Pre-B-Cell Leukemia Transcription Factor 1 - physiology; Protein binding; Proteins; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - physiology; Risk factors; Squamous cell carcinoma; Transcription factors; United Kingdom > UK; United States > US; OSCC; HOX genes; Oral Cancer; HXR9; PBX; Apoptosis

High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein binding to PBX c...