Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes - Platais, Christopher; Radhakrishnan, Raghu; Niklander Ebensperger, Sven; Morgan, Richard; Lambert, Daniel W.; Hunter, Keith D. (BMC cancer, 2018)
Keywords: Aged; Aged, 80 and over; Analysis; Apoptosis; Apoptosis - drug effects; Breast cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Cell culture; Comparative analysis; Female; Gene expression; Genetic aspects; Homeodomain Proteins - antagonists & inhibitors; Homeodomain Proteins - physiology; HOX genes; Humans; HXR9; Intercellular Signaling Peptides and Proteins; Investigations; Keratinocytes; Keratinocytes - drug effects; Kinases; Liver cancer; Lung cancer; Male; Middle Aged; Mouth Neoplasms - drug therapy; Mouth Neoplasms - pathology; Oral Cancer; OSCC; Ovarian cancer; PBX; Peptides; Peptides - therapeutic use; Phenotypes; Pre-B-Cell Leukemia Transcription Factor 1 - antagonists & inhibitors; Pre-B-Cell Leukemia Transcription Factor 1 - physiology; Protein binding; Proteins; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - physiology; Risk factors; Squamous cell carcinoma; Transcription factors; United Kingdom--UK; United States--US; OSCC; HOX genes; Oral Cancer; HXR9; PBX; Apoptosis