LINE-1 hypermethylation in white blood cell DNA is associated with high-grade cervical intraepithelial neoplasia

• Published in: BMC cancer Vol. 17; no. 1; p. 601
• Main Authors: Barchitta, Martina, Quattrocchi, Annalisa, Maugeri, Andrea, Canto, Carolina, La Rosa, Nadia, Cantarella, Maria Antonietta, Spampinato, Giuseppa, Scalisi, Aurora, Agodi, Antonella
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.08.2017; BioMed Central; BMC
• Subjects: Adult; Biomarkers, Tumor - genetics; Bisulfite; Blood; Cancer; Cervical cancer; Cervical Intraepitelial Neoplasia; Cervical Intraepithelial Neoplasia - etiology; Cervical Intraepithelial Neoplasia - genetics; Cervical Intraepithelial Neoplasia - virology; Cervix; Cross-Sectional Studies; Deoxyribonuclease I - genetics; Deoxyribonuclease I - metabolism; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; Early Detection of Cancer - methods; Epigenetics; Epithelium; Female; Gene expression; Genomes; Global DNA methylation; Health aspects; Human papillomavirus; Humans; Hypermethylation; Leukocytes; Leukocytes - metabolism; LINE-1 methylation; Medical screening; Methylation; Oncology, Experimental; Papillomaviridae - pathogenicity; Papillomavirus infections; Papillomavirus Infections - complications; Papillomavirus Infections - genetics; Papillomavirus Infections - virology; Risk factors; ROC curve analysis; Studies; Uterine Cervical Neoplasms - etiology; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - virology; Variables; Womens health; Italy; Prevention; Cervical Intraepitelial Neoplasia; ROC curve analysis; LINE-1 methylation; Global DNA methylation; Pyrosequencing-based methylation analysis; Hypermethylation; Cervical cancer

Long Interspersed Nuclear Elements-1 (LINEs-1) methylation from white blood cells (WBCs) DNA has been proposed as biomarker associated with different types of cancer. The aim of the present study was to investigate the degree of WBCs LINE-1 methylation, according to high-risk Human Papilloma Virus (...