Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders

• Published in: Journal of autism and developmental disorders Vol. 42; no. 3; pp. 432 - 440
• Main Authors: Scahill, Lawrence, McCracken, James T., Bearss, Karen, Robinson, Fay, Hollander, Eric, King, Bryan, Bregman, Joel, Sikich, Lin, Dukes, Kimberly, Sullivan, Lisa, Anagnostou, Evdokia, Donnelly, Craig, Kim, Young-Shin, Ritz, Louise, Hirtz, Deborah, Wagner, Ann
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2012; Springer; Springer Nature B.V
• Subjects: Adolescent; Age; Aggression; Antidepressants; Asperger Syndrome; Autism; Autistic children; Behavior Problems; Behavioral Science and Psychology; Biological and medical sciences; Child; Child and School Psychology; Child clinical studies; Child Development Disorders, Pervasive - drug therapy; Child Health; Children; Citalopram; Citalopram - therapeutic use; Clinical trials; Delayed Speech; Developmental Disabilities; Developmental disorders; Double-Blind Method; Drug Therapy; Female; Humans; Hyperactivity; Impressions; Infantile autism; Interpersonal Relationship; Literary Devices; Male; Medical sciences; Mental health; Mental Retardation; Networks; Neurodevelopmental disorders; Neurological disorders; Neuropharmacology; Neuropsychological Tests; Neurosciences; Original Paper; Outcomes of Treatment; Paediatrics; Pediatrics; Pervasive Developmental Disorders; Pharmaceutical industry; Pharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Public Health; Repetitive behaviour; Research Design; Research Subjects; Sample Size; Self destructive behavior; Serotonin Uptake Inhibitors - therapeutic use; Severity (of Disability); Social interaction; Stroke; Treatment Outcome; Young Children; United States; New York; United States > US; Autism; Double-blind method; Serotonin reuptake inhibitors; Repetitive behavior; Citalopram; Human; Trial; Serotonin; Psychotropic; Developmental disorder; Reuptake inhibitor; Selective serotonin reuptake inhibitor; Pervasive developmental disorder; Neurotransmitter; Double blind study; Antidepressant agent; Child

The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9....