Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy

• Published in: PLoS neglected tropical diseases Vol. 17; no. 3; p. e0011223
• Main Authors: Silva Grijó Farani, Priscila, Iandra da Silva Ferreira, Beatriz, Begum, Khodeza, Vilar-Pereira, Glaucia, Pereira, Isabela Resende, Fernández-Figueroa, Edith A, Cardenas-Ovando, Roberto Alejandro, Almeida, Igor C, Roy, Sourav, Lannes-Vieira, Joseli, Moreira, Otacilio Cruz
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2023; Public Library of Science (PLoS)
• Subjects: Abnormalities; Analysis; Animal models; Animals; Arrhythmia; Benznidazole; Biology and life sciences; Biomarkers; Cardiac arrhythmia; Cardiac muscle; Cardiomyocytes; Cardiomyopathy; Cardiovascular diseases; Cell cycle; Cell death; Cell survival; Chagas Cardiomyopathy - drug therapy; Chagas disease; Chagas Disease - parasitology; Clinical trials; Complications and side effects; Connective tissue; Connective tissues; Cytology; Diagnosis; Disease Models, Animal; Drug therapy; Fibrosis; Gene expression; Gene Expression Profiling; Genetic aspects; Heart; Histology; Immunomodulation; Immunomodulators; Infections; Inflammation; Inflammatory response; Laboratory animals; Malformations; Medicine and Health Sciences; Metabolism; Metabolites; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Morbidity; Myocarditis; Necrosis; Nitroimidazoles - pharmacology; Nitroimidazoles - therapeutic use; Parasites; Pathways; Patient outcomes; Pentoxifylline; Pentoxifylline - pharmacology; Pentoxifylline - therapeutic use; Persistence; Profiling; Proliferation; Protozoa; Research and Analysis Methods; Ribonucleic acid; RNA; Signal transduction; Signaling; Skeletal muscle; Survival; Therapeutic targets; Therapy; Tissue; Tissues; Transcriptome; Transcriptomes; Transcriptomics; Tropical diseases; Trypanocidal Agents - pharmacology; Trypanosoma cruzi - genetics; Vector-borne diseases; Brazil

Chronic Chagas cardiomyopathy (CCC) is one of the leading causes of morbidity and mortality due to cardiovascular disorders in endemic areas of Chagas disease (CD), a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. CCC is characterized by parasite persistence and infla...