Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

• Published in: Journal of hematology and oncology Vol. 13; no. 1; pp. 13 - 10
• Main Authors: Coussy, F, El Botty, R, Lavigne, M, Gu, C, Fuhrmann, L, Briaux, A, de Koning, L, Dahmani, A, Montaudon, E, Morisset, L, Huguet, L, Sourd, L, Painsec, P, Chateau-Joubert, S, Larcher, T, Vacher, S, Melaabi, S, Salomon, A Vincent, Marangoni, E, Bieche, I
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.02.2020; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents - therapeutic use; Arrays; Biotechnology industries; Breast cancer; Breast tumors; Cancer treatment; Chemotherapy; Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Class I Phosphatidylinositol 3-Kinases - genetics; Class I Phosphatidylinositol 3-Kinases - metabolism; Combination of targeted therapies; Comparative analysis; Gene expression; Genes; Genomes; Genomics; Hematology; Humans; Kinases; Life Sciences; MEK inhibitor; MEK inhibitors; Metaplastic breast cancer; Metastasis; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases - metabolism; Mutation; Mutation - drug effects; Oncology; Patients; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositide-3 Kinase Inhibitors - therapeutic use; PI3K inhibitor; Protein Kinase Inhibitors - therapeutic use; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Remission; Short Report; Signal Transduction - drug effects; Stem cells; TOR Serine-Threonine Kinases - metabolism; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Tumors; Xenograft Model Antitumor Assays; Xenografts; United States; France; MEK inhibitor; Metaplastic breast cancer; Combination of targeted therapies; PI3K inhibitor

Metaplastic breast cancer (MBC) is a rare form of breast cancer characterized by an aggressive clinical presentation, with a poor response to standard chemotherapy. MBCs are typically triple-negative breast cancers (TNBCs), frequently with alterations to genes of the PI3K-AKT-mTOR and RTK-MAPK signa...