Differential Lipid Profiles of Normal Human Brain Matter and Gliomas by Positive and Negative Mode Desorption Electrospray Ionization – Mass Spectrometry Imaging

• Published in: PloS one Vol. 11; no. 9; p. e0163180
• Main Authors: Jarmusch, Alan K., Alfaro, Clint M., Pirro, Valentina, Hattab, Eyas M., Cohen-Gadol, Aaron A., Cooks, R. Graham
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.09.2016; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Brain; Brain cancer; Brain tumors; Chemistry; Data integration; Desorption; Discriminant analysis; Electrospraying; Glioma; Histopathology; Human subjects; Ionization; Ions; Lipids; Mass spectrometry; Mass spectroscopy; Medical diagnosis; Medicine and Health Sciences; Metabolites; Multisensor fusion; Neuroimaging; Neurosciences; Parenchyma; Phospholipids; Physical Sciences; Principal components analysis; Research and Analysis Methods; Scientific imaging; Sensitivity; Spectroscopy; Substantia alba; Substantia grisea; Surgery; Tumors; Indiana; United States > US; Indianapolis Indiana

Desorption electrospray ionization-mass spectrometry (DESI-MS) imaging was used to analyze unmodified human brain tissue sections from 39 subjects sequentially in the positive and negative ionization modes. Acquisition of both MS polarities allowed more complete analysis of the human brain tumor lip...