Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

• Published in: Stem cell research & therapy Vol. 8; no. 1; pp. 187 - 13
• Main Authors: Fu, Xiafei, He, Yuanli, Wang, Xuefeng, Peng, Dongxian, Chen, Xiaoying, Li, Xinran, Wang, Qing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.08.2017; BioMed Central; BMC
• Subjects: 17β-Estradiol; Animals; Antineoplastic Agents - adverse effects; Apoptosis; Apoptosis Regulatory Proteins - metabolism; Bone marrow; Bone marrow derived mesenchymal stem cells; Care and treatment; Cell culture; Cells, Cultured; Chemotherapy; Chemotherapy-induced premature ovarian failure; Cyclophosphamide; Development and progression; Estrus cycle; Female; Follicle-stimulating hormone; Gene expression; Genetic aspects; Genetic Vectors - metabolism; Gonadal Steroid Hormones - metabolism; Granulosa cells; Granulosa Cells - metabolism; Granulosa Cells - pathology; Health aspects; Injection; Laboratory animals; Lentivirus - metabolism; Medical research; Mesenchymal stem cells; Mesenchymal Stromal Cells - metabolism; Mesenchyme; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miR-21; miRNA; Organ Size; Ovarian cancer; Ovarian diseases; Ovaries; Ovary - pathology; Patient outcomes; PDCD4; PTEN; PTEN Phosphohydrolase - metabolism; PTEN protein; R&D; Rats, Wistar; Reproductive status; Research & development; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Stem cell transplantation; Stem cells; Stem Cells - metabolism; Structure-function relationships; Transfection; Transplantation; PDCD4; PTEN; Bone marrow derived mesenchymal stem cells; miR-21; Chemotherapy-induced premature ovarian failure; Apoptosis

Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and function damaged by chemotherapy. miR-21 is a microRNA that can regulate cell apoptosis. This st...