JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination
Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear...
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Published in | Frontiers in cellular neuroscience Vol. 8; p. 272 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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12.09.2014
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Abstract | Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse motor cortex (M1), the main excitatory pathway controlling voluntary movement. In Jnk1-/- mice, basal dendrite branching of L5 pyramidal neurons is increased in M1, as is cell soma size, whereas in L2/3, dendritic arborization is decreased. We show that JNK1 phosphorylates rat HMW-MAP2 on T1619, T1622, and T1625 (Uniprot P15146) corresponding to mouse T1617, T1620, T1623, to create a binding motif, that is critical for MAP2 interaction with and stabilization of microtubules, and dendrite growth control. Targeted expression in M1 of GFP-HMW-MAP2 that is pseudo-phosphorylated on T1619, T1622, and T1625 increases dendrite complexity in L2/3 indicating that JNK1 phosphorylation of HMW-MAP2 regulates the dendritic field. Consistent with the morphological changes observed in L2/3 and L5, Jnk1-/- mice exhibit deficits in limb placement and motor coordination, while stride length is reduced in older animals. In summary, JNK1 phosphorylates HMW-MAP2 to increase its stabilization of microtubules while at the same time controlling dendritic fields in the main excitatory pathway of M1. Moreover, JNK1 contributes to normal functioning of fine motor coordination. We report for the first time, a quantitative Sholl analysis of dendrite architecture, and of motor behavior in Jnk1-/- mice. Our results illustrate the molecular and behavioral consequences of interrupted JNK1 signaling and provide new ground for mechanistic understanding of those prevalent neuropyschiatric disorders where genetic disruption of the JNK pathway is central. |
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AbstractList | Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse motor cortex (M1), the main excitatory pathway controlling voluntary movement. In Jnk1-/- mice, basal dendrite branching of L5 pyramidal neurons is increased in M1, as is cell soma size, whereas in L2/3, dendritic arborization is decreased. We show that JNK1 phosphorylates rat HMW-MAP2 on T1619, T1622, and T1625 (Uniprot P15146) corresponding to mouse T1617, T1620, T1623, to create a binding motif, that is critical for MAP2 interaction with and stabilization of microtubules, and dendrite growth control. Targeted expression in M1 of GFP-HMW-MAP2 that is pseudo-phosphorylated on T1619, T1622, and T1625 increases dendrite complexity in L2/3 indicating that JNK1 phosphorylation of HMW-MAP2 regulates the dendritic field. Consistent with the morphological changes observed in L2/3 and L5, Jnk1-/- mice exhibit deficits in limb placement and motor coordination, while stride length is reduced in older animals. In summary, JNK1 phosphorylates HMW-MAP2 to increase its stabilization of microtubules while at the same time controlling dendritic fields in the main excitatory pathway of M1. Moreover, JNK1 contributes to normal functioning of fine motor coordination. We report for the first time, a quantitative Sholl analysis of dendrite architecture, and of motor behavior in Jnk1-/- mice. Our results illustrate the molecular and behavioral consequences of interrupted JNK1 signaling and provide new ground for mechanistic understanding of those prevalent neuropyschiatric disorders where genetic disruption of the JNK pathway is central. Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse motor cortex (M1), the main excitatory pathway controlling voluntary movement. In Jnk1-/- mice, basal dendrite branching of L5 pyramidal neurons is increased in M1, as is cell soma size, whereas in L2/3, dendritic arborization is decreased. We show that JNK1 phosphorylates rat HMW-MAP2 on T1619, T1622, and T1625 (Uniprot P15146) corresponding to mouse T1617, T1620, T1623, to create a binding motif, that is critical for MAP2 interaction with and stabilization of microtubules, and dendrite growth control. Targeted expression in M1 of GFP-HMW-MAP2 that is pseudo-phosphorylated on T1619, T1622, and T1625 increases dendrite complexity in L2/3 indicating that JNK1 phosphorylation of HMW-MAP2 regulates the dendritic field. Consistent with the morphological changes observed in L2/3 and L5, Jnk1-/- mice exhibit deficits in limb placement and motor coordination, while stride length is reduced in older animals. In summary, JNK1 phosphorylates HMW-MAP2 to increase its stabilization of microtubules while at the same time controlling dendritic fields in the main excitatory pathway of M1. Moreover, JNK1 contributes to normal functioning of fine motor coordination. We report for the first time, a quantitative Sholl analysis of dendrite architecture, and of motor behavior in Jnk1-/- mice. Our results illustrate the molecular and behavioral consequences of interrupted JNK1 signaling and provide new ground for mechanistic understanding of those prevalent neuropyschiatric disorders where genetic disruption of the JNK pathway is central. |
Author | Deshpande, Prasannakumar Mågard, Mats James, Peter Marchisella, Francesca Rauvala, Heikki Kulesskaya, Natalia Komulainen, Emilia Hollos, Patrik Zdrojewska, Justyna Mysore, Raghavendra Michelsen, Kimmo A Mohammad, Hasan Freemantle, Erika Coffey, Eleanor T |
AuthorAffiliation | 1 Turku Centre for Biotechnology, Åbo Akademi University and University of Turku Turku, Finland 2 Neuroscience Center, University of Helsinki Helsinki, Finland 3 Department of Biosciences, Åbo Akademi University Turku, Finland 4 Institute for Immune Technology, Medicon Village, University of Lund Lund, Sweden |
AuthorAffiliation_xml | – name: 1 Turku Centre for Biotechnology, Åbo Akademi University and University of Turku Turku, Finland – name: 4 Institute for Immune Technology, Medicon Village, University of Lund Lund, Sweden – name: 2 Neuroscience Center, University of Helsinki Helsinki, Finland – name: 3 Department of Biosciences, Åbo Akademi University Turku, Finland |
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Cites_doi | 10.3389/fnana.2011.00005 10.1083/jcb.200110134 10.1083/jcb.200201048 10.1083/jcb.114.4.735 10.1111/j.1749-6632.1995.tb26683.x 10.1126/stke.2982005pl6 10.1146/annurev-neuro-062111-150414 10.1038/nature12975 10.1016/j.pneurobio.2011.08.003 10.1523/JNEUROSCI.1517-05.2005 10.1093/cercor/bhq159 10.1056/NEJMoa075974 10.1007/s00439-012-1260-5 10.1016/S0920-9964(02)00201-3 10.3389/fncel.2013.00174 10.1101/gad.1984311 10.1523/JNEUROSCI.23-29-09479.2003 10.1016/j.bbr.2012.04.051 10.1016/S1534-5807(03)00094-7 10.1126/science.1089845 10.1371/journal.pbio.1001439 10.1523/JNEUROSCI.1745-13.2013 10.1016/j.cub.2004.01.058 10.1007/s00439-005-0084-y 10.1242/jcs.00082 10.1016/S0079-6123(08)62550-9 10.3389/fncir.2013.00075 10.1016/j.neuron.2007.09.007 10.1001/archpsyc.55.3.215 10.1038/ng.474 10.1074/mcp.M600046-MCP200 10.1126/science.1089071 10.1523/JNEUROSCI.20-20-07602.2000 10.1111/j.1750-3639.2007.00102.x 10.1523/JNEUROSCI.2625-06.2006 10.1002/cm.20284 10.1097/00001756-199304000-00020 10.1128/MCB.00713-12 10.1038/nature07454 10.1016/S0301-0082(99)00046-5 10.1038/nn.3141 10.1093/cercor/10.10.981 10.1016/j.cub.2009.12.030 10.1016/S0166-2236(03)00035-3 10.1016/j.conb.2012.07.002 10.1242/jcs.001461 10.1016/0031-9384(92)90174-Z 10.1016/S0165-0270(02)00012-2 10.1002/ana.410360208 10.1093/hmg/dds331 10.1073/pnas.181342398 10.1093/emboj/20.18.5114 10.1083/jcb.138.5.1067 10.1074/jbc.M112.417881 10.1002/dev.20337 10.1038/nn.2755 10.1016/j.ajhg.2008.02.012 10.1074/mcp.T500041-MCP200 10.1038/nrn3729 10.1128/MCB.01166-09 10.1152/jn.1999.82.6.3268 10.1038/nrn2652 10.1038/nrn2836 10.1038/nature12929 10.1042/bj3060481 10.1146/annurev.neuro.28.061604.135703 10.1038/nrn2286 10.1159/000339456 10.1177/1073858404270843 10.1083/jcb.200511055 10.1083/jcb.132.4.667 10.1128/MCB.02227-06 10.1038/sj.emboj.7601969 10.1038/nn1374 |
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Copyright | 2014. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2014 Komulainen, Zdrojewska, Freemantle, Mohammad, Kulesskaya, Deshpande, Marchisella, Mysore, Hollos, Michelsen, Mågard, Rauvala, James and Coffey. 2014 |
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Keywords | motor cortex MAP2 cytoskeleton JNK dendrite microtubules schizophrenia behavior |
Language | English |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Karl Farrow, Neuroelectronics Research Flanders, Belgium; Jie Cui, Roskamp Institute, USA This article was submitted to the journal Frontiers in Cellular Neuroscience. Edited by: Tycho M. Hoogland, Netherlands Institute for Neuroscience, Netherlands |
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References | 24336718 - J Neurosci. 2013 Dec 11;33(50):19518-33 18923510 - Nature. 2008 Oct 16;455(7215):890-3 16000625 - J Neurosci. 2005 Jul 6;25(27):6350-61 21369363 - Front Neuroanat. 2011 Feb 17;5:5 7887902 - Biochem J. 1995 Mar 1;306 ( Pt 2):481-7 15746384 - Neuroscientist. 2005 Apr;11(2):161-73 12689591 - Dev Cell. 2003 Apr;4(4):521-33 18511961 - Acta Neurobiol Exp (Wars). 2008;68(2):264-88 12363393 - Schizophr Res. 2002 Nov 1;58(1):75-81 12082079 - J Cell Biol. 2002 Jun 24;157(7):1187-96 17389683 - J Cell Sci. 2007 Apr 15;120(Pt 8):1447-56 8647897 - J Cell Biol. 1996 Feb;132(4):667-79 1523229 - Physiol Behav. 1992 Mar;51(3):523-5 9510215 - Arch Gen Psychiatry. 1998 Mar;55(3):215-24 18270515 - Nat Rev Neurosci. 2008 Mar;9(3):206-21 16452087 - Mol Cell Proteomics. 2006 May;5(5):914-22 12591217 - Trends Neurosci. 2003 Mar;26(3):147-54 23223444 - J Biol Chem. 2013 Jan 18;288(3):1883-95 8499602 - Neuroreport. 1993 Apr;4(4):419-22 23226105 - PLoS Biol. 2012;10 (12 ):e1001439 1907976 - J Cell Biol. 1991 Aug;114(4):735-43 22814247 - Neuropsychobiology. 2012;66(2):77-92 20176805 - Mol Cell Biol. 2010 May;30(9):2241-50 18195042 - Mol Cell Biol. 2008 Mar;28(5):1515-27 17988632 - Neuron. 2007 Nov 8;56(3):488-502 19855392 - Nat Genet. 2009 Nov;41(11):1223-7 17114649 - Mol Cell Proteomics. 2007 Feb;6(2):283-93 11517324 - Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41 16249883 - Hum Genet. 2006 Jan;118(5):559-67 16971530 - J Neurosci. 2006 Sep 13;26(37):9462-70 15608632 - Nat Neurosci. 2005 Jan;8(1):34-42 24463507 - Nature. 2014 Feb 13;506(7487):179-84 24137110 - Front Cell Neurosci. 2013 Oct 16;7:174 24739785 - Nat Rev Neurosci. 2014 May;15(5):285-99 14716005 - Science. 2004 Jan 9;303(5655):197-202 9281584 - J Cell Biol. 1997 Sep 8;138(5):1067-75 11992668 - J Neurosci Methods. 2002 Apr 15;115(2):169-79 22751924 - Mol Cell Biol. 2012 Sep;32(17):3513-26 18184952 - N Engl J Med. 2008 Feb 14;358(7):667-75 15028210 - Curr Biol. 2004 Mar 9;14(5):363-71 21325132 - Genes Dev. 2011 Feb 15;25(4):310-22 23754982 - Front Neural Circuits. 2013 May 28;7:75 22841417 - Curr Opin Neurobiol. 2012 Oct;22(5):812-21 22683681 - Nat Neurosci. 2012 Jun 10;15(7):1022-31 10601459 - J Neurophysiol. 1999 Dec;82(6):3268-85 7486678 - Ann N Y Acad Sci. 1995 Sep 7;766:303-19 12163474 - J Cell Biol. 2002 Aug 5;158(3):541-9 11007549 - Cereb Cortex. 2000 Oct;10(10):981-91 11566876 - EMBO J. 2001 Sep 17;20(18):5114-28 12376563 - J Cell Sci. 2002 Nov 15;115(Pt 22):4317-25 14593168 - Science. 2003 Oct 31;302(5646):826-30 21297631 - Nat Neurosci. 2011 Mar;14(3):305-13 17919129 - Brain Pathol. 2007 Oct;17(4):434-47 23329067 - Hum Genet. 2013 Apr;132(4):461-71 23841842 - Annu Rev Neurosci. 2013 Jul 8;36:547-68 19513088 - Nat Rev Neurosci. 2009 Jul;10(7):519-29 10704996 - Prog Neurobiol. 2000 Jun;61(2):133-68 20404840 - Nat Rev Neurosci. 2010 May;11(5):316-28 11027220 - J Neurosci. 2000 Oct 15;20(20):7602-13 16033324 - Annu Rev Neurosci. 2005;28:503-32 24463508 - Nature. 2014 Feb 13;506(7487):185-90 14573527 - J Neurosci. 2003 Oct 22;23(29):9479-90 16118397 - Sci STKE. 2005 Aug 23;2005(298):pl6 22580166 - Behav Brain Res. 2012 Jul 15;233(1):169-75 20739477 - Cereb Cortex. 2011 Apr;21(4):865-76 18985861 - Dev Psychobiol. 2008 Nov;50(7):633-9 18473367 - Cell Motil Cytoskeleton. 2008 Jul;65(7):515-27 8979812 - Prog Brain Res. 1996;108:333-46 18371933 - Am J Hum Genet. 2008 Apr;82(4):927-36 8053652 - Ann Neurol. 1994 Aug;36(2):166-75 16618812 - J Cell Biol. 2006 Apr 24;173(2):265-77 22899651 - Hum Mol Genet. 2012 Nov 15;21(22):4910-21 20096586 - Curr Biol. 2010 Jan 26;20(2):103-15 21907759 - Prog Neurobiol. 2011 Nov;95(3):275-300 18188153 - EMBO J. 2008 Jan 23;27(2):361-72 Harada (B26) 2002; 158 Ohkawa (B46) 2007; 120 Snow (B62) 2008; 50 Williams (B74) 2003; 26 Hof (B28) 2000 Shoichet (B61) 2006; 118 Thomas (B66) 2008; 27 Kaufmann (B35) 2000; 10 Martin (B42) 2005; 11 Jiang (B33) 2013; 33 Kaneko (B34) 2013; 7 Hyman (B30) 2008; 455 Villanueva (B70) 2001; 20 Munton (B45) 2007; 6 Tennant (B65) 2011; 21 Weiss (B72) 2008; 358 Farah (B20) 2008; 65 Levine (B40) 2012; 22 Rosso (B58) 2005; 8 Jaffe (B31) 1999; 82 Zoghbi (B79) 2003; 302 Bjorkblom (B8) 2012; 32 Baptista (B5) 2008; 82 Brugg (B11) 1991; 114 Gilman (B25) 1994; 36 Pardo (B49) 2007; 17 Broadbelt (B9) 2002; 58 Coffey (B14) 2000; 20 Rajkowska (B54) 1998; 55 Oswald (B48) 2013; 7 Baldo (B4) 2012; 233 Chang (B12) 2003; 4 Podkowa (B51) 2010; 30 Young (B77) 2012 de Anda (B17) 2012; 15 Trinidad (B67) 2006; 5 Zipursky (B78) 2013; 36 Westerlund (B73) 2011; 14 Aizawa (B1) 2004; 303 Oliva (B47) 2006; 26 Sanchez (B60) 2000; 61 Walther (B71) 2012; 66 Hirokawa (B27) 1996; 132 Al-Bassam (B2) 2002; 157 David (B16) 2002; 115 Kim (B36) 2007; 56 Sánchez (B59) 1995 Collins (B15) 2005; 2005 Spruston (B63) 2008; 9 van Pelt (B69) 1996; 108 Feltrin (B22) 2012; 10 Kunde (B37) 2013; 132 Coffey (B13) 2014; 15 Pavlowsky (B50) 2010; 20 London (B41) 2005; 28 Rall (B55) 1977 Tararuk (B64) 2006; 173 Winchester (B75) 2012; 21 Bennett (B6) 2011; 95 Kyriakis (B38) 1995; 766 Brooks (B10) 2009; 10 Gilman (B24) 1981 Xu (B76) 2011; 25 Jan (B32) 2010; 11 Qu (B53) 2013; 288 DÃez-Guerra (B19) 1993; 4 Purcell (B52) 2014; 506 Björkblom (B7) 2005; 25 Hongisto (B29) 2008; 28 Metz (B44) 2002; 115 McCarthy (B43) 2009; 41 Urbanska (B68) 2008; 68 Baker (B3) 2001; 98 Fromer (B23) 2014; 506 Lalonde (B39) 1992; 51 Felgner (B21) 1997; 138 Roger (B56) 2004; 14 Romand (B57) 2011; 5 Dehmelt (B18) 2003; 23 |
References_xml | – volume: 5 issue: 5 year: 2011 ident: B57 article-title: Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex. publication-title: Front. Neuroanat. doi: 10.3389/fnana.2011.00005 contributor: fullname: Romand – volume: 158 start-page: 541 year: 2002 ident: B26 article-title: MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. publication-title: J. Cell Biol. doi: 10.1083/jcb.200110134 contributor: fullname: Harada – volume: 157 start-page: 1187 year: 2002 ident: B2 article-title: MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. publication-title: J. Cell Biol. doi: 10.1083/jcb.200201048 contributor: fullname: Al-Bassam – volume: 114 start-page: 735 year: 1991 ident: B11 article-title: Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells. publication-title: J. Cell Biol. doi: 10.1083/jcb.114.4.735 contributor: fullname: Brugg – volume: 766 start-page: 303 year: 1995 ident: B38 article-title: The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines. publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1995.tb26683.x contributor: fullname: Kyriakis – year: 1977 ident: B55 publication-title: Core Conductor Theory and Cable Properties of Neurons. Handbook of Physiology: The Nervous System1. contributor: fullname: Rall – volume: 2005 year: 2005 ident: B15 article-title: Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry. publication-title: Sci. STKE doi: 10.1126/stke.2982005pl6 contributor: fullname: Collins – volume: 36 start-page: 547 year: 2013 ident: B78 article-title: The molecular basis of self-avoidance. publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev-neuro-062111-150414 contributor: fullname: Zipursky – volume: 506 start-page: 185 year: 2014 ident: B52 article-title: A polygenic burden of rare disruptive mutations in schizophrenia. publication-title: Nature doi: 10.1038/nature12975 contributor: fullname: Purcell – volume: 95 start-page: 275 year: 2011 ident: B6 article-title: Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss. publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2011.08.003 contributor: fullname: Bennett – volume: 25 start-page: 6350 year: 2005 ident: B7 article-title: Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1517-05.2005 contributor: fullname: Björkblom – volume: 21 start-page: 865 year: 2011 ident: B65 article-title: The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. publication-title: Cereb. Cortex doi: 10.1093/cercor/bhq159 contributor: fullname: Tennant – volume: 358 start-page: 667 year: 2008 ident: B72 article-title: Association between microdeletion and microduplication at 16p11.2 and autism. publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa075974 contributor: fullname: Weiss – volume: 68 start-page: 264 year: 2008 ident: B68 article-title: Molecular basis of dendritic arborization. publication-title: Acta Neurobiol. Exp. (Wars.) contributor: fullname: Urbanska – volume: 132 start-page: 461 year: 2013 ident: B37 article-title: Characterisation of de novo MAPK10/JNK3 truncation mutations associated with cognitive disorders in two unrelated patients. publication-title: Hum. Genet. doi: 10.1007/s00439-012-1260-5 contributor: fullname: Kunde – volume: 58 start-page: 75 year: 2002 ident: B9 article-title: Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex. publication-title: Schizophr. Res. doi: 10.1016/S0920-9964(02)00201-3 contributor: fullname: Broadbelt – volume: 7 issue: 174 year: 2013 ident: B48 article-title: Diversity of layer 5 projection neurons in the mouse motor cortex. publication-title: Front. Cell Neurosci. doi: 10.3389/fncel.2013.00174 contributor: fullname: Oswald – volume: 25 start-page: 310 year: 2011 ident: B76 article-title: JNK regulates FoxO-dependent autophagy in neurons. publication-title: Genes Dev. doi: 10.1101/gad.1984311 contributor: fullname: Xu – volume: 23 start-page: 9479 year: 2003 ident: B18 article-title: The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-29-09479.2003 contributor: fullname: Dehmelt – volume: 233 start-page: 169 year: 2012 ident: B4 article-title: Evidence of a progressive motor dysfunction in Mucopolysaccharidosis type I mice. publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2012.04.051 contributor: fullname: Baldo – volume: 4 start-page: 521 year: 2003 ident: B12 article-title: JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00094-7 contributor: fullname: Chang – year: 2000 ident: B28 publication-title: Comparative Cytoarchitectonic Atlas of the C57BL/6 and 129/Sv Mouse Brains. contributor: fullname: Hof – volume: 303 start-page: 197 year: 2004 ident: B1 article-title: Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. publication-title: Science doi: 10.1126/science.1089845 contributor: fullname: Aizawa – volume: 10 issue: e1001439 year: 2012 ident: B22 article-title: Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1001439 contributor: fullname: Feltrin – volume: 33 start-page: 19518 year: 2013 ident: B33 article-title: Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1745-13.2013 contributor: fullname: Jiang – volume: 14 start-page: 363 year: 2004 ident: B56 article-title: MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. publication-title: Curr. Biol. doi: 10.1016/j.cub.2004.01.058 contributor: fullname: Roger – year: 2012 ident: B77 publication-title: The Mouse Nervous System contributor: fullname: Young – volume: 118 start-page: 559 year: 2006 ident: B61 article-title: Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. publication-title: Hum. Genet. doi: 10.1007/s00439-005-0084-y contributor: fullname: Shoichet – volume: 115 start-page: 4317 year: 2002 ident: B16 article-title: JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms. publication-title: J. Cell Sci. doi: 10.1242/jcs.00082 contributor: fullname: David – volume: 108 start-page: 333 year: 1996 ident: B69 article-title: Growth cone dynamics and activity-dependent processes in neuronal network development. publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(08)62550-9 contributor: fullname: van Pelt – volume: 7 issue: 75 year: 2013 ident: B34 article-title: Local connections of excitatory neurons in motor-associated cortical areas of the rat. publication-title: Front. Neural Circuits doi: 10.3389/fncir.2013.00075 contributor: fullname: Kaneko – volume: 56 start-page: 488 year: 2007 ident: B36 article-title: Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95. publication-title: Neuron doi: 10.1016/j.neuron.2007.09.007 contributor: fullname: Kim – volume: 55 start-page: 215 year: 1998 ident: B54 article-title: Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington disease. publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.55.3.215 contributor: fullname: Rajkowska – volume: 41 start-page: 1223 year: 2009 ident: B43 article-title: Microduplications of 16p11.2 are associated with schizophrenia. publication-title: Nat. Genet. doi: 10.1038/ng.474 contributor: fullname: McCarthy – volume: 6 start-page: 283 year: 2007 ident: B45 article-title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M600046-MCP200 contributor: fullname: Munton – volume: 302 start-page: 826 year: 2003 ident: B79 article-title: Postnatal neurodevelopmental disorders: meeting at the synapse? publication-title: Science doi: 10.1126/science.1089071 contributor: fullname: Zoghbi – volume: 20 start-page: 7602 year: 2000 ident: B14 article-title: Dual roles for c-Jun N-terminal kinase in developmental and stress responses in. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.20-20-07602.2000 contributor: fullname: Coffey – volume: 17 start-page: 434 year: 2007 ident: B49 article-title: The neurobiology of autism. publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2007.00102.x contributor: fullname: Pardo – volume: 26 start-page: 9462 year: 2006 ident: B47 article-title: Activated c-Jun N-terminal kinase is required for axon formation. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2625-06.2006 contributor: fullname: Oliva – volume: 65 start-page: 515 year: 2008 ident: B20 article-title: HMWMAP2: new perspectives on a pathway to dendritic identity. publication-title: Cell Motil. Cytoskeleton doi: 10.1002/cm.20284 contributor: fullname: Farah – volume: 4 start-page: 419 year: 1993 ident: B19 article-title: MAP2 phosphorylation parallels dendrite arborization in hippocampal neurones in culture. publication-title: Neuroreport doi: 10.1097/00001756-199304000-00020 contributor: fullname: DÃez-Guerra – volume: 32 start-page: 3513 year: 2012 ident: B8 article-title: c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability. publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00713-12 contributor: fullname: Bjorkblom – volume: 455 start-page: 890 year: 2008 ident: B30 article-title: A glimmer of light for neuropsychiatric disorders. publication-title: Nature doi: 10.1038/nature07454 contributor: fullname: Hyman – volume: 61 start-page: 133 year: 2000 ident: B60 article-title: Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for. publication-title: Prog. Neurobiol. doi: 10.1016/S0301-0082(99)00046-5 contributor: fullname: Sanchez – volume: 15 start-page: 1022 year: 2012 ident: B17 article-title: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. publication-title: Nat. Neurosci. doi: 10.1038/nn.3141 contributor: fullname: de Anda – volume: 10 start-page: 981 year: 2000 ident: B35 article-title: Dendritic anomalies in disorders associated with mental retardation. publication-title: Cereb. Cortex doi: 10.1093/cercor/10.10.981 contributor: fullname: Kaufmann – year: 1981 ident: B24 publication-title: Disorders of the Cerebellum. contributor: fullname: Gilman – volume: 20 start-page: 103 year: 2010 ident: B50 article-title: A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation. publication-title: Curr. Biol. doi: 10.1016/j.cub.2009.12.030 contributor: fullname: Pavlowsky – volume: 26 start-page: 147 year: 2003 ident: B74 article-title: Role of dendritic synapse location in the control of action potential output. publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(03)00035-3 contributor: fullname: Williams – volume: 22 start-page: 812 year: 2012 ident: B40 article-title: Spatial organization of cortical and spinal neurons controlling motor behavior. publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2012.07.002 contributor: fullname: Levine – volume: 120 start-page: 1447 year: 2007 ident: B46 article-title: The microtubule destabilizer stathmin mediates the development of dendritic arbors in neuronal cells. publication-title: J. Cell Sci. doi: 10.1242/jcs.001461 contributor: fullname: Ohkawa – volume: 51 start-page: 523 year: 1992 ident: B39 article-title: Motor abnormalities in lurcher mutant mice. publication-title: Physiol. Behav. doi: 10.1016/0031-9384(92)90174-Z contributor: fullname: Lalonde – volume: 115 start-page: 169 year: 2002 ident: B44 article-title: Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination. publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(02)00012-2 contributor: fullname: Metz – volume: 36 start-page: 166 year: 1994 ident: B25 article-title: Patterns of cerebral glucose metabolism detected with positron emission tomography differ in multiple system atrophy and olivopontocerebellar atrophy. publication-title: Ann. Neurol. doi: 10.1002/ana.410360208 contributor: fullname: Gilman – volume: 21 start-page: 4910 year: 2012 ident: B75 article-title: Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds331 contributor: fullname: Winchester – volume: 98 start-page: 10037 year: 2001 ident: B3 article-title: Electrostatics of nanosystems: application to microtubules and the ribosome. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.181342398 contributor: fullname: Baker – volume: 20 start-page: 5114 year: 2001 ident: B70 article-title: jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. publication-title: EMBO J. doi: 10.1093/emboj/20.18.5114 contributor: fullname: Villanueva – volume: 138 start-page: 1067 year: 1997 ident: B21 article-title: Domains of neuronal microtubule-associated proteins and flexural rigidity of microtubules. publication-title: J. Cell Biol. doi: 10.1083/jcb.138.5.1067 contributor: fullname: Felgner – volume: 288 start-page: 1883 year: 2013 ident: B53 article-title: c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.417881 contributor: fullname: Qu – volume: 50 start-page: 633 year: 2008 ident: B62 article-title: Altered morphology of motor cortex neurons in the VPA rat model of autism. publication-title: Dev. Psychobiol. doi: 10.1002/dev.20337 contributor: fullname: Snow – volume: 14 start-page: 305 year: 2011 ident: B73 article-title: Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. publication-title: Nat. Neurosci. doi: 10.1038/nn.2755 contributor: fullname: Westerlund – volume: 82 start-page: 927 year: 2008 ident: B5 article-title: Breakpoint mapping and array CGH in translocations: comparison of a phenotypically normal and an abnormal cohort. publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.02.012 contributor: fullname: Baptista – volume: 5 start-page: 914 year: 2006 ident: B67 article-title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations. publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.T500041-MCP200 contributor: fullname: Trinidad – volume: 15 start-page: 285 year: 2014 ident: B13 article-title: Nuclear and cytosolic JNK signalling in neurons. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3729 contributor: fullname: Coffey – volume: 30 start-page: 2241 year: 2010 ident: B51 article-title: Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01166-09 contributor: fullname: Podkowa – volume: 82 start-page: 3268 year: 1999 ident: B31 article-title: Passive normalization of synaptic integration influenced by dendritic architecture. publication-title: J. Neurophysiol. doi: 10.1152/jn.1999.82.6.3268 contributor: fullname: Jaffe – volume: 10 start-page: 519 year: 2009 ident: B10 article-title: Tests to assess motor phenotype in mice: a user’s guide. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2652 contributor: fullname: Brooks – volume: 11 start-page: 316 year: 2010 ident: B32 article-title: Branching out: mechanisms of dendritic arborization. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2836 contributor: fullname: Jan – volume: 506 start-page: 179 year: 2014 ident: B23 article-title: De novo mutations in schizophrenia implicate synaptic networks. publication-title: Nature doi: 10.1038/nature12929 contributor: fullname: Fromer – start-page: 481 year: 1995 ident: B59 article-title: Variations in in vivo phosphorylation at the proline-rich domain of the microtubule-associated protein 2 (MAP2) during rat brain development. publication-title: Biochem. J. doi: 10.1042/bj3060481 contributor: fullname: Sánchez – volume: 28 start-page: 503 year: 2005 ident: B41 article-title: Dendritic computation. publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.28.061604.135703 contributor: fullname: London – volume: 9 start-page: 206 year: 2008 ident: B63 article-title: Pyramidal neurons: dendritic structure and synaptic integration. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2286 contributor: fullname: Spruston – volume: 66 start-page: 77 year: 2012 ident: B71 article-title: Motor symptoms and schizophrenia. publication-title: Neuropsychobiology doi: 10.1159/000339456 contributor: fullname: Walther – volume: 11 start-page: 161 year: 2005 ident: B42 article-title: The corticospinal system: from development to motor control. publication-title: Neuroscientist doi: 10.1177/1073858404270843 contributor: fullname: Martin – volume: 173 start-page: 265 year: 2006 ident: B64 article-title: JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. publication-title: J. Cell Biol. doi: 10.1083/jcb.200511055 contributor: fullname: Tararuk – volume: 132 start-page: 667 year: 1996 ident: B27 article-title: Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons. publication-title: J. Cell Biol. doi: 10.1083/jcb.132.4.667 contributor: fullname: Hirokawa – volume: 28 start-page: 1515 year: 2008 ident: B29 article-title: The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death. publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.02227-06 contributor: fullname: Hongisto – volume: 27 start-page: 361 year: 2008 ident: B66 article-title: Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK. publication-title: EMBO J. doi: 10.1038/sj.emboj.7601969 contributor: fullname: Thomas – volume: 8 start-page: 34 year: 2005 ident: B58 article-title: Wnt signaling through dishevelled, Rac and JNK regulates dendritic development. publication-title: Nat. Neurosci. doi: 10.1038/nn1374 contributor: fullname: Rosso |
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Snippet | Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a... Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia and intellectual disability. The mechanism whereby a... |
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SubjectTerms | Autism Basic Medicine Behavior Cell size Cloning Cortex (motor) Cytoskeleton Dendrites Dendritic branching Genes Intellectual disabilities Intellectual Disability Kinases Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Mental disorders Microtubules Motor Cortex Neurons Neuroscience Neurosciences Neurovetenskaper Phosphorylation Pyramidal cells Schizophrenia Signal transduction |
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Title | JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination |
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