Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

• Published in: Cell systems Vol. 11; no. 1; pp. 11 - 24.e4
• Main Authors: Messner, Christoph B., Demichev, Vadim, Wendisch, Daniel, Michalick, Laura, White, Matthew, Freiwald, Anja, Textoris-Taube, Kathrin, Vernardis, Spyros I., Egger, Anna-Sophia, Kreidl, Marco, Ludwig, Daniela, Kilian, Christiane, Agostini, Federica, Zelezniak, Aleksej, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, von Kalle, Christof, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Langenberg, Claudia, Lilley, Kathryn S., Kuebler, Wolfgang M., Mülleder, Michael, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Kurth, Florian, Sander, Leif Erik, Ralser, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.07.2020; Cell Press
• Subjects: Adult; Aged; Aged, 80 and over; antiviral immune response; Betacoronavirus - isolation & purification; Biomarkers - blood; Blood Proteins - analysis; Blood Proteins - metabolism; clinical classifiers; Coronavirus Infections - blood; Coronavirus Infections - classification; Coronavirus Infections - pathology; Coronavirus Infections - virology; COVID-19; COVID-19 infection; Female; high-throughput proteomics; Humans; Male; mass spectrometry; Middle Aged; Pandemics - classification; Pneumonia, Viral - blood; Pneumonia, Viral - classification; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Proteomics - methods; SARS-CoV-2; SWATH-MS; Young Adult; mass spectrometry; SWATH-MS; clinical classifiers; antiviral immune response; COVID-19 infection; high-throughput proteomics

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clini...