The association between fecal enterotoxigenic B. fragilis with colorectal cancer

• Published in: BMC cancer Vol. 19; no. 1; p. 879
• Main Authors: Haghi, Fakhri, Goli, Elshan, Mirzaei, Bahman, Zeighami, Habib
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.09.2019; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Antibiotics; Bacterial Toxins - genetics; Bacteroides fragilis; Bacteroides fragilis - genetics; Bacteroides fragilis - isolation & purification; Bacteroides Infections - microbiology; bft gene; Biomarkers, Tumor - genetics; Cancer; Cancer diagnosis; Care and treatment; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - microbiology; Data analysis; Deoxyribonucleic acid; Diagnosis; Diarrhea; DNA; DNA damage; Enterotoxin; Enterotoxins - genetics; Epithelial cells; Feces - microbiology; Female; Gastrointestinal diseases; Gastrointestinal Microbiome; Gene expression; Genes; Genetic aspects; Genetic testing; Healthy Volunteers; Humans; Immune response; Iran; Isotypes; Male; Metalloendopeptidases - genetics; Microbiota; Middle Aged; Mucosal immunity; Neoplasm Staging; Polymerase Chain Reaction; Risk factors; Stool; Studies; Tumors; Iran; Enterotoxin; bft gene; Stool; Bacteroides fragilis; Colorectal cancer

Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell changes. The aim of this study was to investigate the freque...