Beneficial Effects of Reconstituted High-Density Lipoprotein (rHDL) on Circulating CD34+ Cells in Patients after an Acute Coronary Syndrome

• Published in: PloS one Vol. 12; no. 1; p. e0168448
• Main Authors: Gebhard, Catherine, Rhéaume, Eric, Berry, Colin, Brand, Geneviève, Kernaleguen, Anne-Elen, Théberge-Julien, Gabriel, Alam, Mohammad Afaque, Lee, Candace Y W, Boileau, Laurianne, Chabot-Blanchet, Malorie, Guertin, Marie-Claude, Lavoie, Marc-André, Grégoire, Jean, Ibrahim, Réda, L'Allier, Philippe, Tardif, Jean-Claude
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2017; Public Library of Science (PLoS)
• Subjects: Acute Coronary Syndrome - drug therapy; Acute coronary syndromes; Antigens, CD34; Apoptosis; Atherosclerosis; Biology and Life Sciences; Bone marrow; Cardiovascular disease; CD34 antigen; Cell Adhesion - drug effects; Cell Movement - drug effects; Cells (biology); Cholesterol; Cholesterol, HDL - therapeutic use; Cytometry; Diabetes; Endothelial Progenitor Cells - drug effects; Female; Flow cytometry; Heart attacks; High density lipoprotein; Humans; Intravenous administration; Lipoproteins; Low density lipoprotein; Male; Medicine and Health Sciences; Middle Aged; Patients; Phosphatidylcholines - therapeutic use; Population studies; Progenitor cells; Research and Analysis Methods; SDF-1 protein; Stem cells; Studies

High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS). This study investigates the short-term effects of reconstituted HDL (rHDL) on circulating progenitor cells...