Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum

• Published in: Stem cell research & therapy Vol. 7; no. 1; p. 84
• Main Authors: Wystrychowski, Wojciech, Patlolla, Bhagat, Zhuge, Yan, Neofytou, Evgenios, Robbins, Robert C., Beygui, Ramin E.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.06.2016; BioMed Central
• Subjects: Actinin - genetics; Actinin - metabolism; Adipocytes - cytology; Adipocytes - drug effects; Adipocytes - metabolism; Adult; Aged; Alkaline Phosphatase - genetics; Alkaline Phosphatase - metabolism; Antigens, CD - genetics; Antigens, CD - metabolism; Azacitidine - pharmacology; Biomarkers - metabolism; Cell differentiation; Cell Transdifferentiation; DNA Methylation - drug effects; Female; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; GATA4 Transcription Factor - genetics; GATA4 Transcription Factor - metabolism; Gene Expression; Growth; Heart cells; Heart Transplantation; Humans; Male; Middle Aged; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Nanog Homeobox Protein - genetics; Nanog Homeobox Protein - metabolism; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Omentum - cytology; Omentum - drug effects; Omentum - metabolism; Osteocytes - cytology; Osteocytes - drug effects; Osteocytes - metabolism; Pericardium - cytology; Pericardium - drug effects; Pericardium - metabolism; Primary Cell Culture; Stem cell research; Stem cells; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism; Transcription Factors - pharmacology; Troponin T - genetics; Troponin T - metabolism; Alkaline phosphatase; Adipose tissue; Reprogramming; Epicardium; Fibroblasts; Cardiomyocytes; Adipose-derived stem cells; Cardiogenesis; Mesenchymal stem cells; Pericardium

Acute myocardial infarction (MI) leads to an irreversible loss of proper cardiac function. Application of stem cell therapy is an attractive option for MI treatment. Adipose tissue has proven to serve as a rich source of stem cells (ADSCs). Taking into account the different morphogenesis, anatomy, a...