Annexin A1 involved in the regulation of inflammation and cell signaling pathways
With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functi...
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| Published in | Chinese journal of traumatology Vol. 23; no. 2; pp. 96 - 101 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
Elsevier B.V
01.04.2020
Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China%Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China Elsevier |
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| Abstract | With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper. |
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| AbstractList | With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper. With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper. Keywords: Annexin A1, Inflammatory, Signal pathway, Cell proliferation, Apoptosis With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper.With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper. |
| Abstract_FL | With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper. |
| Author | Li, Peng-Cui Han, Peng-Fei Wei, Xiao-Chun Gao, Yang-Yang Li, Hong-Zhuo Che, Xian-Da |
| AuthorAffiliation | Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China%Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China |
| AuthorAffiliation_xml | – name: Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China%Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China – name: b Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China – name: a Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China |
| Author_FL | Li Peng-Cui Han Peng-Fei Che Xian-Da Wei Xiao-Chun Li Hong-Zhuo Gao Yang-Yang |
| Author_FL_xml | – sequence: 1 fullname: Han Peng-Fei – sequence: 2 fullname: Che Xian-Da – sequence: 3 fullname: Li Hong-Zhuo – sequence: 4 fullname: Gao Yang-Yang – sequence: 5 fullname: Wei Xiao-Chun – sequence: 6 fullname: Li Peng-Cui |
| Author_xml | – sequence: 1 givenname: Peng-Fei surname: Han fullname: Han, Peng-Fei organization: Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China – sequence: 2 givenname: Xian-Da surname: Che fullname: Che, Xian-Da organization: Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China – sequence: 3 givenname: Hong-Zhuo surname: Li fullname: Li, Hong-Zhuo organization: Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China – sequence: 4 givenname: Yang-Yang surname: Gao fullname: Gao, Yang-Yang organization: Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China – sequence: 5 givenname: Xiao-Chun surname: Wei fullname: Wei, Xiao-Chun organization: Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China – sequence: 6 givenname: Peng-Cui surname: Li fullname: Li, Peng-Cui email: lpc1977@163.com organization: Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32201231$$D View this record in MEDLINE/PubMed |
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| Keywords | Cell proliferation Inflammatory Signal pathway Annexin A1 Apoptosis |
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| Title | Annexin A1 involved in the regulation of inflammation and cell signaling pathways |
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