Melatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo
Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various a...
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Published in | Stem cell research & therapy Vol. 10; no. 1; pp. 13 - 11 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
11.01.2019
BioMed Central BMC |
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Abstract | Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various advantages compared to other stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); thus, MSCs have been intensely investigated in recent studies. However, they are placed in a harsh environment after isolation and transplantation, and the adverse microenvironment substantially reduces the viability and therapeutic effects of MSCs. Intriguingly, melatonin (MT), which is primarily secreted by the pineal organ, has been found to influence the fate of MSCs during various physiological and pathological processes. In this review, we will focus on the recent progress made regarding the influence of MT on stem cell biology and its implications for regenerative medicine. In addition, several biomaterials have been proven to significantly improve the protective effects of MT on MSCs by controlling the release of MT. Collectively, MT will be a promising agent for enhancing MSC activities and the regenerative capacity via the regulation of reactive oxygen species (ROS) generation and the release of immune factors in regenerative medicine. |
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AbstractList | Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various advantages compared to other stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); thus, MSCs have been intensely investigated in recent studies. However, they are placed in a harsh environment after isolation and transplantation, and the adverse microenvironment substantially reduces the viability and therapeutic effects of MSCs. Intriguingly, melatonin (MT), which is primarily secreted by the pineal organ, has been found to influence the fate of MSCs during various physiological and pathological processes. In this review, we will focus on the recent progress made regarding the influence of MT on stem cell biology and its implications for regenerative medicine. In addition, several biomaterials have been proven to significantly improve the protective effects of MT on MSCs by controlling the release of MT. Collectively, MT will be a promising agent for enhancing MSC activities and the regenerative capacity via the regulation of reactive oxygen species (ROS) generation and the release of immune factors in regenerative medicine. Abstract Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various advantages compared to other stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); thus, MSCs have been intensely investigated in recent studies. However, they are placed in a harsh environment after isolation and transplantation, and the adverse microenvironment substantially reduces the viability and therapeutic effects of MSCs. Intriguingly, melatonin (MT), which is primarily secreted by the pineal organ, has been found to influence the fate of MSCs during various physiological and pathological processes. In this review, we will focus on the recent progress made regarding the influence of MT on stem cell biology and its implications for regenerative medicine. In addition, several biomaterials have been proven to significantly improve the protective effects of MT on MSCs by controlling the release of MT. Collectively, MT will be a promising agent for enhancing MSC activities and the regenerative capacity via the regulation of reactive oxygen species (ROS) generation and the release of immune factors in regenerative medicine. |
ArticleNumber | 13 |
Audience | Academic |
Author | Li, Lanjuan Hu, Chenxia |
Author_xml | – sequence: 1 givenname: Chenxia surname: Hu fullname: Hu, Chenxia organization: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China – sequence: 2 givenname: Lanjuan surname: Li fullname: Li, Lanjuan email: ljli@zju.edu.cn organization: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. ljli@zju.edu.cn |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30635065$$D View this record in MEDLINE/PubMed |
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Keywords | Mesenchymal stem cell In vivo Therapy Melatonin Regenerative medicine In vitro Protection |
Language | English |
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SubjectTerms | Apoptosis Biomaterials Biomedical materials Bone marrow Cell Proliferation - genetics Cytokines Embryo cells Embryonic Stem Cells - metabolism Gene expression Humans In vitro In vivo Induced Pluripotent Stem Cells - metabolism Ischemia Medicine Melatonin Melatonin - metabolism Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - metabolism Mesenchyme Oxidation Oxidative stress Physiology Pineal gland Pluripotency Protection Reactive oxygen species Regenerative Medicine Review Senescence Sepsis Stem cells Transplantation Tumorigenicity |
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Title | Melatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo |
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