Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study

• Published in: BMC cancer Vol. 19; no. 1; pp. 1257 - 10
• Main Authors: AL-Eitan, Laith N., Rababa’h, Doaa M., Alghamdi, Mansour A., Khasawneh, Rame H.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.12.2019; BioMed Central; BMC
• Subjects: Analysis; Arabs; Breast cancer; Breast Neoplasms - genetics; Cancer patients; Cancer research; Case-Control Studies; Cell proliferation; Chromosomes; Deoxyribonucleic acid; Development and progression; DNA; Drug metabolism; ErbB-2 protein; ESR; ESR1 protein; Estrogen Receptor alpha - genetics; Estrogen Receptor beta - genetics; Female; Gene Frequency; Gene polymorphism; Genes; Genetic aspects; Genetic Association Studies; Genetic diversity; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic testing; Genotype; Genotyping; Glucuronosyltransferase - genetics; Health aspects; HER2; Humans; Jordan; Jordanian; Kinases; Medical prognosis; Metastasis; Minority & ethnic groups; Mutation; Patients; Polymorphism; Polymorphism, Single Nucleotide; Population studies; Prognosis; Receptor, ErbB-2 - genetics; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Tumor suppression; Tumors; UGT1A4; UGT2B7; Jordan; Canada; United States > US; UGT1A4; Jordanian; Breast cancer; HER2; ESR; UGT2B7

Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question,...