Timing of Transcriptional Quiescence during Gametogenesis Is Controlled by Global Histone H3K4 Demethylation

• Published in: Developmental cell Vol. 23; no. 5; pp. 1059 - 1071
• Main Authors: Xu, Mengshu, Soloveychik, Maria, Ranger, Mathieu, Schertzberg, Michael, Shah, Zarna, Raisner, Ryan, Venkatasubrahmanyan, Shivkumar, Tsui, Kyle, Gebbia, Marinella, Hughes, Tim, van Bakel, Harm, Nislow, Corey, Madhani, Hiten D., Meneghini, Marc D.
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 13.11.2012; Cell Press
• Subjects: animals; Biological and medical sciences; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Epigenesis, Genetic; Fundamental and applied biological sciences. Psychology; gametogenesis; Gametogenesis - genetics; Gametogenesis - physiology; Genes, Fungal; germ cells; histones; Histones - metabolism; Jumonji Domain-Containing Histone Demethylases - genetics; Jumonji Domain-Containing Histone Demethylases - metabolism; Meiosis; Methylation; Molecular and cellular biology; Molecular genetics; mutants; Mutation; nucleosomes; Nucleosomes - metabolism; progeny; Ribosomal Proteins - genetics; Ribosomal Proteins - metabolism; RNA, Fungal - genetics; RNA, Fungal - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; spores; Spores, Fungal - genetics; Spores, Fungal - growth & development; Spores, Fungal - metabolism; Telomere-Binding Proteins - genetics; Telomere-Binding Proteins - metabolism; Time Factors; transcription (genetics); Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; yeasts; Demethylation; Transcription; Gametogenesis; Development; Timing; Histone; Quiescence

Gametes are among the most highly specialized cells produced during development. Although gametogenesis culminates in transcriptional quiescence in plants and animals, regulatory mechanisms controlling this are unknown. Here, we confirm that gamete differentiation in the single-celled yeast Saccharo...