The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster

• Published in: Nature genetics Vol. 29; no. 4; pp. 389 - 395
• Main Authors: Jin, Wei, Riley, Rebecca M., Wolfinger, Russell D., White, Kevin P., Passador-Gurgel, Gisele, Gibson, Greg
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2001; Nature Publishing Group
• Subjects: Aging - genetics; Aging - physiology; Agriculture; Analytical methods; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - physiology; Experimental design; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Function; Genetic aspects; Genetics; Genotype; Human Genetics; Male; Molecular and cellular biology; Molecular genetics; Physiological aspects; Sex Factors; Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; United States; Transcription; Arthropoda; Insecta; Sex; Genotype; Invertebrata; Drosophila melanogaster; Diptera; Age; Variance; Drosophilidae

Here we present a statistically rigorous approach to quantifying microarray expression data that allows the relative effects of multiple classes of treatment to be compared and incorporates analytical methods that are common to quantitative genetics. From the magnitude of gene effects and contributi...