Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 152; no. 1; pp. 111 - 123.e8
• Main Authors: Tap, Julien, Derrien, Muriel, Törnblom, Hans, Brazeilles, Rémi, Cools-Portier, Stéphanie, Doré, Joël, Störsrud, Stine, Le Nevé, Boris, Öhman, Lena, Simrén, Magnus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2017; Elsevier
• Subjects: Adult; Bacteria; Bacteroides - isolation & purification; Breath Tests; Case-Control Studies; Clostridiales - isolation & purification; DNA, Bacterial - analysis; Feces - microbiology; Female; Functional Bowel Disorder; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastrointestinal Microbiome; Gastrointestinal Transit; Humans; Hydrogen - analysis; Intestinal Mucosa - microbiology; Irritable Bowel Syndrome - microbiology; Irritable Bowel Syndrome - physiopathology; Life Sciences; Machine Learning; Male; Methane - analysis; Methanobacteriales - isolation & purification; Microbiology in the Medical Area; Microbiome; Microbiota; Mikrobiologi inom det medicinska området; Prevotella - isolation & purification; Prospective Studies; RNA, Ribosomal, 16S - analysis; Severity of Illness Index; Young Adult; GI; Functional Bowel Disorder; RV; rRNA; AUROC; HAD; FODMAP; IBS-SSS; AUC; OTU; IBS-D; IBS-C; PC; OATT; LASSO; Bacteria; IBS-M; JSD; IBS; PCR; Microbiome; BMI; bacteria; microbiome; Operational Taxonomic Unit; IBS Symptom Severity Score; BSF; Irritable Bowel Syndrome; Bristol Stool Form; Oro-Anal Transit Time; functional bowel disorder; Jensen Shannon Divergence

We have limited knowledge about the association between the composition of the intestinal microbiota and clinical features of irritable bowel syndrome (IBS). We collected information on the fecal and mucosa-associated microbiota of patients with IBS and evaluated whether these were associated with s...