Long-term survival of an elderly patient with advanced gastric cancer after combination therapy: a case report and literature review

Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. A 75-year-old man was...

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Published inBMC cancer Vol. 19; no. 1; pp. 459 - 7
Main Authors Li, Qingwei, Xu, Xuejun, Su, Dan, Zhou, Tianshuo, Wang, Guangyu, Li, Zhiwei
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 16.05.2019
BioMed Central
BMC
Subjects
Adenocarcinoma
Biopsy
Blood clots
Breast cancer
Cancer
Cancer metastasis
Cancer patients
Cancer therapies
Cancer treatment
Care and treatment
Case Report
Case reports
Chemotherapy
Combination therapy
Diagnosis
Elderly
Elderly patients
ErbB-2 protein
Gastrectomy
Gastric cancer
Gastrointestinal hemorrhage
Gene amplification
Genes
Geriatrics
Health aspects
Helium
Literature reviews
Liver
Liver cancer
Liver metastasis
Lung cancer
Medical prognosis
Metastases
Metastasis
Patient outcomes
Patients
Peripheral blood
Pertuzumab
Stomach cancer
Surgery
Survival
Chemotherapy
Combination therapy
Gastric cancer
Liver metastasis
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Abstract Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)'s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC. Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
AbstractList Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
Background Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. Case presentation A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)'s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC. Conclusions Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM. Keywords: Gastric cancer, Liver metastasis, Chemotherapy, Combination therapy
Abstract Background Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. Case presentation A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)‘s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC. Conclusions Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
Background Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. Case presentation A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)‘s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC. Conclusions Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified. A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)'s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC. Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified.BACKGROUNDGastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatment of GCLM, especially in elderly patients, has yet to be clarified.A 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)'s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC.CASE PRESENTATIONA 75-year-old man was diagnosed with advanced gastric cancer (GC), presenting with acute gastrointestinal bleeding and synchronous metastatic lesion in liver. Based on multidisciplinary team (MDT)'s decision, this patient underwent distal palliative gastrectomy with R1 margin. Histopathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), HER2 negative. The patient was treated with chemotherapy and argon-helium cryoablation of liver and lung metastases.HER-2 gene amplification was identified in peripheral blood at later stage of therapy. The patient had been followed-up for 39 months, in sharp contrast to a median survival time of 13.8 months for majority of advanced GC.Palliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.CONCLUSIONSPalliative distal gastrectomy in combination with chemotherapy and cryoablation significantly prolongs overall survival of an elderly patient with GCLM.
ArticleNumber 459
Audience Academic
Author Li, Qingwei
Li, Zhiwei
Zhou, Tianshuo
Su, Dan
Wang, Guangyu
Xu, Xuejun
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Cites_doi 10.1002/jso.20739
10.1007/s00423-012-0959-z
10.1016/j.suronc.2009.02.001
10.1245/s10434-018-6608-1
10.1097/PPO.0b013e3181d7ea07
10.1093/annonc/mdn026
10.1093/annonc/mdv611
10.1093/carcin/bgp263
10.1007/s00268-009-0034-2
10.1016/j.ejrad.2009.12.009
10.1016/S1470-2045(15)00553-7
10.1007/s00268-005-0129-3
10.1007/s00534-009-0081-y
10.1002/jso.24004
10.1016/j.ejso.2013.03.023
10.1002/jso.23940
10.1097/SLE.0b013e3181a033d7
10.1007/s00595-009-4152-0
10.1007/s10120-015-0522-z
10.1007/s10120-016-0622-4
10.3109/02656730903555696
10.1067/msy.2003.147
10.1016/j.ejso.2015.05.005
10.1245/s10434-015-4422-6
10.1245/s10434-010-0985-4
10.1007/s10434-001-0038-0
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Issue 1
Keywords Chemotherapy
Combination therapy
Gastric cancer
Liver metastasis
Language English
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References J Liu (5683_CR3) 2011; 124
J Yu (5683_CR21) 2011; 79
J Chen (5683_CR23) 2013; 39
C Boutros (5683_CR20) 2010; 19
Y Kakeji (5683_CR17) 2010; 40
L Vigano (5683_CR5) 2013; 60
SE Hwang (5683_CR6) 2009; 33
Y Sakamoto (5683_CR7) 2007; 95
HO Kim (5683_CR19) 2009; 19
Association JGC (5683_CR27) 2017; 20
RF Saidi (5683_CR13) 2006; 30
T Nomura (5683_CR16) 2009; 16
N Niikura (5683_CR29) 2016; 27
S Cheon (5683_CR14) 2008; 19
Y Sakamoto (5683_CR15) 2003; 133
VE Strong (5683_CR4) 2015; 112
K Fujitani (5683_CR10) 2016; 17
LM De La Cruz (5683_CR28) 2018; 25
A Guner (5683_CR24) 2016; 19
H Nienhueser (5683_CR25) 2015; 112
SC Mayo (5683_CR22) 2010; 16
T Schmidt (5683_CR26) 2015; 41
MJ Thun (5683_CR1) 2010; 31
M Fukuchi (5683_CR9) 2015; 22
MD McCarter (5683_CR12) 2001; 8
5683_CR2
N Takemura (5683_CR8) 2012; 397
HR Kim (5683_CR18) 2010; 26
SB Edge (5683_CR11) 2010; 17
References_xml – volume: 60
  start-page: 557
  issue: 123
  year: 2013
  ident: 5683_CR5
  publication-title: Hepato-gastroenterology
– volume: 95
  start-page: 534
  issue: 7
  year: 2007
  ident: 5683_CR7
  publication-title: J Surg Oncol
  doi: 10.1002/jso.20739
– volume: 397
  start-page: 951
  issue: 6
  year: 2012
  ident: 5683_CR8
  publication-title: Langenbeck's Arch Surg
  doi: 10.1007/s00423-012-0959-z
– volume: 19
  start-page: e22
  issue: 1
  year: 2010
  ident: 5683_CR20
  publication-title: Surg Oncol
  doi: 10.1016/j.suronc.2009.02.001
– volume: 25
  start-page: 3535
  issue: 12
  year: 2018
  ident: 5683_CR28
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-018-6608-1
– volume: 16
  start-page: 111
  issue: 2
  year: 2010
  ident: 5683_CR22
  publication-title: Cancer J
  doi: 10.1097/PPO.0b013e3181d7ea07
– volume: 19
  start-page: 1146
  issue: 6
  year: 2008
  ident: 5683_CR14
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdn026
– volume: 27
  start-page: 480
  issue: 3
  year: 2016
  ident: 5683_CR29
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdv611
– volume: 31
  start-page: 100
  issue: 1
  year: 2010
  ident: 5683_CR1
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp263
– volume: 33
  start-page: 1468
  issue: 7
  year: 2009
  ident: 5683_CR6
  publication-title: World J Surg
  doi: 10.1007/s00268-009-0034-2
– volume: 79
  start-page: 124
  issue: 1
  year: 2011
  ident: 5683_CR21
  publication-title: Eur J Radiol
  doi: 10.1016/j.ejrad.2009.12.009
– volume: 17
  start-page: 309
  issue: 3
  year: 2016
  ident: 5683_CR10
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(15)00553-7
– volume: 124
  start-page: 445
  issue: 3
  year: 2011
  ident: 5683_CR3
  publication-title: Chin Med J
– volume: 30
  start-page: 21
  issue: 1
  year: 2006
  ident: 5683_CR13
  publication-title: World J Surg
  doi: 10.1007/s00268-005-0129-3
– volume: 16
  start-page: 493
  issue: 4
  year: 2009
  ident: 5683_CR16
  publication-title: J Hepato-Biliary-Pancreat Surg
  doi: 10.1007/s00534-009-0081-y
– volume: 112
  start-page: 387
  issue: 4
  year: 2015
  ident: 5683_CR25
  publication-title: J Surg Oncol
  doi: 10.1002/jso.24004
– volume: 39
  start-page: 701
  issue: 7
  year: 2013
  ident: 5683_CR23
  publication-title: Eur J Surg Oncol
  doi: 10.1016/j.ejso.2013.03.023
– volume: 112
  start-page: 31
  issue: 1
  year: 2015
  ident: 5683_CR4
  publication-title: J Surg Oncol
  doi: 10.1002/jso.23940
– volume: 19
  start-page: 208
  issue: 3
  year: 2009
  ident: 5683_CR19
  publication-title: Surg Laparosc Endosc Percutan Tech
  doi: 10.1097/SLE.0b013e3181a033d7
– volume: 40
  start-page: 287
  issue: 4
  year: 2010
  ident: 5683_CR17
  publication-title: Surg Today
  doi: 10.1007/s00595-009-4152-0
– volume: 19
  start-page: 951
  issue: 3
  year: 2016
  ident: 5683_CR24
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-015-0522-z
– volume: 20
  start-page: 1
  issue: 1
  year: 2017
  ident: 5683_CR27
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-016-0622-4
– volume: 26
  start-page: 305
  issue: 4
  year: 2010
  ident: 5683_CR18
  publication-title: Int J Hyperth
  doi: 10.3109/02656730903555696
– volume: 133
  start-page: 507
  issue: 5
  year: 2003
  ident: 5683_CR15
  publication-title: Surgery
  doi: 10.1067/msy.2003.147
– ident: 5683_CR2
– volume: 41
  start-page: 1340
  issue: 10
  year: 2015
  ident: 5683_CR26
  publication-title: Eur J Surg Oncol
  doi: 10.1016/j.ejso.2015.05.005
– volume: 22
  start-page: 3618
  issue: 11
  year: 2015
  ident: 5683_CR9
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-015-4422-6
– volume: 17
  start-page: 1471
  issue: 6
  year: 2010
  ident: 5683_CR11
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-010-0985-4
– volume: 8
  start-page: 38
  issue: 1
  year: 2001
  ident: 5683_CR12
  publication-title: Ann Surg Oncol
  doi: 10.1007/s10434-001-0038-0
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Snippet Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM)...
Background Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver...
Abstract Background Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with...
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SubjectTerms Adenocarcinoma
Biopsy
Blood clots
Breast cancer
Cancer
Cancer metastasis
Cancer patients
Cancer therapies
Cancer treatment
Care and treatment
Case Report
Case reports
Chemotherapy
Combination therapy
Diagnosis
Elderly
Elderly patients
ErbB-2 protein
Gastrectomy
Gastric cancer
Gastrointestinal hemorrhage
Gene amplification
Genes
Geriatrics
Health aspects
Helium
Literature reviews
Liver
Liver cancer
Liver metastasis
Lung cancer
Medical prognosis
Metastases
Metastasis
Patient outcomes
Patients
Peripheral blood
Pertuzumab
Stomach cancer
Surgery
Survival
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Title Long-term survival of an elderly patient with advanced gastric cancer after combination therapy: a case report and literature review
URI https://www.ncbi.nlm.nih.gov/pubmed/31096933
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Volume 19
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