Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

• Published in: The Journal of clinical investigation Vol. 122; no. 5; pp. 1791 - 1802
• Main Authors: Harre, Ulrike, Georgess, Dan, Bang, Holger, Bozec, Aline, Axmann, Roland, Ossipova, Elena, Jakobsson, Per-Johan, Baum, Wolfgang, Nimmerjahn, Falk, Szarka, Eszter, Sarmay, Gabriella, Krumbholz, Grit, Neumann, Elena, Toes, Rene, Scherer, Hans-Ulrich, Catrina, Anca Irinel, Klareskog, Lars, Jurdic, Pierre, Schett, Georg
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.05.2012
• Subjects: Animals; Antibody Specificity; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; Autoantibodies; Autoantibodies - blood; Autoantibodies - isolation & purification; Autoantibodies - metabolism; Biomarkers - blood; Biomedical research; Bone and Bones - immunology; Bone and Bones - pathology; Bone resorption; Bone Resorption - immunology; Case-Control Studies; Cell Differentiation; Cells, Cultured; Citrulline; Citrulline - immunology; Collagen Type I - blood; Enzymes; Humans; Hydrolases - metabolism; Immune system; Inflammatory diseases; Influence; Medicin och hälsovetenskap; Metabolism; Mice; Mice, Transgenic; Osteoclasts (Biology); Osteoclasts - enzymology; Osteoclasts - metabolism; Osteoclasts - physiology; Phosphatase; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Proteins; Rheumatoid arthritis; Tumor Necrosis Factor-alpha - blood; Vimentin - immunology

Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated proteins are among the strongest risk factors for bone destruction. We therefore hypothesized that these autoantibodies directly influence bo...