Implications of HIV diversity for the HIV-1 pandemic

• Published in: The Journal of infection Vol. 66; no. 5; pp. 391 - 400
• Main Author: Hemelaar, Joris
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.05.2013; Elsevier
• Subjects: Biological and medical sciences; CRF; Diversity; General aspects; Genetic Variation; HIV; HIV Infections - epidemiology; HIV Infections - transmission; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - pathogenicity; HIV-1 - physiology; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious Disease; Infectious diseases; Medical sciences; Pandemics; Recombinant; Simian immunodeficiency virus; Subtype; Vaccine; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Vaccine; HIV; Subtype; CRF; Diversity; Recombinant; Infection; Virus; Immunopathology; HIV-1 virus; Viral disease; Retroviridae; AIDS; Human immunodeficiency virus; Immune deficiency; Lentivirus

HIV-1 genetic variability within individuals and populations plays a central role in the HIV pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombin...