Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2011-2016

A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope p...

Full description

Saved in:
Bibliographic Details
Published inPLoS neglected tropical diseases Vol. 12; no. 9; p. e0006773
Main Authors Yang, Cheng-Fen, Chang, Shu-Fen, Hsu, Tung-Chien, Su, Chien-Ling, Wang, Tzy-Chen, Lin, Shih-Hung, Yang, Su-Lin, Lin, Chien-Chou, Shu, Pei-Yun
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.09.2018
Public Library of Science (PLoS)
Subjects
Analysis
Biology and Life Sciences
Computer and Information Sciences
Countries
Dengue
Dengue fever
Disease control
Earth Sciences
Ecology and Environmental Sciences
Epidemics
Epidemiology
Gene sequencing
Genetic aspects
Genotypes
Geographical distribution
Human diseases
Medicine and Health Sciences
Microbiological strains
People and Places
Phylogeny
Risk factors
Strains
Strains (organisms)
Transmission
Tropical diseases
Vector-borne diseases
Viral diseases
Viral envelope proteins
Viruses
Taiwan
Laos
China
Indonesia
Online AccessGet full text

Cover

Abstract A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope protein gene sequences from 784 imported dengue virus (DENV) isolates were conducted, and the results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype of DENV strains circulating in Southeast Asia. The DENV-1 genotype III, DENV-3 genotype III and DENV-4 genotype I and II strains were found to be newly emerging in several Southeast Asian countries. Our results also showed that geographical restrictions of DENV-1 genotype I, DENV-1 genotype III and DENV-2 Cosmopolitan genotype are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between nations in Southeast Asia. In this study, we present the geographic distribution and dynamic transmission of DENV strains circulating in Southeast Asian countries. In addition, we demonstrated local dengue epidemics caused by several imported DENV strains in Taiwan during 2011-2016.
AbstractList A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope protein gene sequences from 784 imported dengue virus (DENV) isolates were conducted, and the results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype of DENV strains circulating in Southeast Asia. The DENV-1 genotype III, DENV-3 genotype III and DENV-4 genotype I and II strains were found to be newly emerging in several Southeast Asian countries. Our results also showed that geographical restrictions of DENV-1 genotype I, DENV-1 genotype III and DENV-2 Cosmopolitan genotype are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between nations in Southeast Asia. In this study, we present the geographic distribution and dynamic transmission of DENV strains circulating in Southeast Asian countries. In addition, we demonstrated local dengue epidemics caused by several imported DENV strains in Taiwan during 2011-2016.
A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope protein gene sequences from 784 imported dengue virus (DENV) isolates were conducted, and the results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype of DENV strains circulating in Southeast Asia. The DENV-1 genotype III, DENV-3 genotype III and DENV-4 genotype I and II strains were found to be newly emerging in several Southeast Asian countries. Our results also showed that geographical restrictions of DENV-1 genotype I, DENV-1 genotype III and DENV-2 Cosmopolitan genotype are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between nations in Southeast Asia. In this study, we present the geographic distribution and dynamic transmission of DENV strains circulating in Southeast Asian countries. In addition, we demonstrated local dengue epidemics caused by several imported DENV strains in Taiwan during 2011-2016.A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope protein gene sequences from 784 imported dengue virus (DENV) isolates were conducted, and the results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype of DENV strains circulating in Southeast Asia. The DENV-1 genotype III, DENV-3 genotype III and DENV-4 genotype I and II strains were found to be newly emerging in several Southeast Asian countries. Our results also showed that geographical restrictions of DENV-1 genotype I, DENV-1 genotype III and DENV-2 Cosmopolitan genotype are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between nations in Southeast Asia. In this study, we present the geographic distribution and dynamic transmission of DENV strains circulating in Southeast Asian countries. In addition, we demonstrated local dengue epidemics caused by several imported DENV strains in Taiwan during 2011-2016.
A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011–2016. Most of the imported cases arrived from Southeast Asia as well as the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the complete envelope protein gene sequences from 784 imported dengue virus (DENV) isolates were conducted, and the results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype of DENV strains circulating in Southeast Asia. The DENV-1 genotype III, DENV-3 genotype III and DENV-4 genotype I and II strains were found to be newly emerging in several Southeast Asian countries. Our results also showed that geographical restrictions of DENV-1 genotype I, DENV-1 genotype III and DENV-2 Cosmopolitan genotype are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between nations in Southeast Asia. In this study, we present the geographic distribution and dynamic transmission of DENV strains circulating in Southeast Asian countries. In addition, we demonstrated local dengue epidemics caused by several imported DENV strains in Taiwan during 2011–2016. Dengue is the most prevalent mosquito-borne viral disease in the world. The expansion of dengue viruses to different parts of the world has been accelerated by the increase in worldwide travel and trade. In this study, we present the results of a laboratory-based dengue surveillance in Taiwan during 2011–2016. A total of 1,596 laboratory-confirmed imported dengue cases were identified. The travelers were infected in 29 countries in Southeast Asia, the Indian subcontinent, the Pacific region, Latin America, Australia and Africa. Phylogenetic analyses of the envelope gene sequences of 784 imported dengue virus isolates suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant serotype/genotype DENV strains circulating in Southeast Asia. Our results also showed that geographical restrictions of some of the DENV genotypes are becoming blurred, indicating the extensive introductions and continuous expansions of DENV strains between countries in Southeast Asia. In addition, we demonstrated dengue outbreaks in Taiwan caused by viruses imported from Asia and the Americas. The DENV envelope gene sequences from this study will contribute to a better understanding of the genetic evolution, dynamic transmission and global expansion of dengue viruses.
Audience Academic
Author Shu, Pei-Yun
Yang, Cheng-Fen
Wang, Tzy-Chen
Chang, Shu-Fen
Lin, Chien-Chou
Hsu, Tung-Chien
Su, Chien-Ling
Lin, Shih-Hung
Yang, Su-Lin
AuthorAffiliation Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China
Mahidol Univ, Fac Trop Med, THAILAND
AuthorAffiliation_xml – name: Mahidol Univ, Fac Trop Med, THAILAND
– name: Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China
Author_xml – sequence: 1
  givenname: Cheng-Fen
  surname: Yang
  fullname: Yang, Cheng-Fen
– sequence: 2
  givenname: Shu-Fen
  surname: Chang
  fullname: Chang, Shu-Fen
– sequence: 3
  givenname: Tung-Chien
  surname: Hsu
  fullname: Hsu, Tung-Chien
– sequence: 4
  givenname: Chien-Ling
  surname: Su
  fullname: Su, Chien-Ling
– sequence: 5
  givenname: Tzy-Chen
  surname: Wang
  fullname: Wang, Tzy-Chen
– sequence: 6
  givenname: Shih-Hung
  surname: Lin
  fullname: Lin, Shih-Hung
– sequence: 7
  givenname: Su-Lin
  surname: Yang
  fullname: Yang, Su-Lin
– sequence: 8
  givenname: Chien-Chou
  surname: Lin
  fullname: Lin, Chien-Chou
– sequence: 9
  givenname: Pei-Yun
  orcidid: 0000-0002-1670-9749
  surname: Shu
  fullname: Shu, Pei-Yun
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30235208$$D View this record in MEDLINE/PubMed
BookMark eNp9kluL2zAQhU3Z0r20_6C0hkLpS1LJsmR7HwrL0svClr5sn8VkPE4UFCmV7C3pr6-ycUqyLLXBl9F3jjTDOc9OnHeUZa85m3JR8Y9LPwQHdrp2fTtljKmqEs-yM94IOSkqIU8Ovk-z8xiXjMlG1vxFdipYIWTB6rPMfveWcLAQclxAAOwpmD_QG-9ycG2-Xmysn5Oj3mAqgN1EE3Pf5S25-UD5vQlDpJib1dqHntrcuN7nd2B-g8vbIRg3zwvG-SQ91MvseQc20qvxfZH9_PL57vrb5PbH15vrq9sJqqLsJ1TXyEVDyCUizio5m81A1UpIhjXjBbVAhVINsPTHEBhHaliBHfGuggbFRfZ257u2PupxUFEXhSwEY7ziibjZEa2HpV4Hs4Kw0R6Mfij4MNcQUsuWdNNx2ZUijY6pssaqlg0vUUhJ2HVtQ8nr07jbMFtRi-T6APbI9HjFmYWe-3utuKq5VMngw2gQ_K-BYq9XJiJZC478kM7N0yVLrpqEvnuEPt3dSM0hNWBc59O-uDXVV1JWSqiGlYmaPkGlu6WVwRS2zqT6keD9gWBBYPtF9HbYhiUeg28OJ_JvFPvYJeByB2DwMQbqNJr-IXTpCMZqzvQ24_vm9Dbjesx4EpePxHv__8r-AuIRAa0
CitedBy_id crossref_primary_10_3390_tropicalmed6030162
crossref_primary_10_1371_journal_pntd_0010780
crossref_primary_10_1371_journal_pone_0237384
crossref_primary_10_1186_s40001_023_01454_3
crossref_primary_10_1016_j_meegid_2022_105308
crossref_primary_10_1371_journal_pone_0251314
crossref_primary_10_3390_ijerph191711096
crossref_primary_10_3390_microorganisms9112263
crossref_primary_10_1016_j_meegid_2019_103977
crossref_primary_10_3390_microorganisms11051267
crossref_primary_10_1093_infdis_jiac014
crossref_primary_10_3390_v12080829
crossref_primary_10_3390_life10080152
crossref_primary_10_1111_tmi_14095
crossref_primary_10_1371_journal_pone_0257460
crossref_primary_10_3390_pathogens9090728
crossref_primary_10_1016_j_jmii_2024_07_004
crossref_primary_10_1371_journal_pntd_0008302
crossref_primary_10_1371_journal_ppat_1009480
crossref_primary_10_3390_v15051144
Cites_doi 10.1038/nature12060
10.4269/ajtmh.14-0588
10.3201/eid2302.160751
10.1371/journal.pntd.0006203
10.1371/journal.pntd.0001760
10.1006/viro.2002.1447
10.1128/CDLI.10.4.622-630.2003
10.1186/s12879-017-2401-1
10.1016/j.tim.2013.12.011
10.1371/journal.pntd.0004010
10.1371/journal.pntd.0000481
10.1038/srep16913
10.1093/nar/22.22.4673
10.1093/molbev/msw054
10.1016/S0140-6736(14)60572-9
10.1371/journal.pone.0115569
10.1080/20477724.2016.1184864
10.4269/ajtmh.2007.77.903
10.4269/ajtmh.15-0534
10.1099/0022-1317-75-1-65
10.1371/journal.pntd.0002354
10.4269/ajtmh.2009.80.1039
10.1093/jmedent/44.2.205
10.1099/0022-1317-70-1-37
10.1128/JCM.41.6.2408-2416.2003
10.1016/j.virol.2004.08.029
10.1186/1471-2148-13-213
10.4269/ajtmh.2012.11-0666
10.3201/eid1103.040420
10.1371/journal.pntd.0002769
10.3201/eid0403.980326
10.1016/S0065-3527(03)59002-9
10.1016/j.jinf.2015.10.007
10.1016/j.virol.2004.08.003
10.1371/journal.pntd.0004995
ContentType Journal Article
Copyright COPYRIGHT 2018 Public Library of Science
2018 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2018 Yang et al 2018 Yang et al
Copyright_xml – notice: COPYRIGHT 2018 Public Library of Science
– notice: 2018 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2018 Yang et al 2018 Yang et al
DBID AAYXX
CITATION
NPM
3V.
7QL
7SS
7T2
7T7
7U9
7X7
7XB
88E
8C1
8FD
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BENPR
C1K
CCPQU
DWQXO
F1W
FR3
FYUFA
GHDGH
H94
H95
H97
K9.
L.G
M0S
M1P
M7N
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1371/journal.pntd.0006773
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Entomology Abstracts (Full archive)
Health and Safety Science Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Public Health
Technology Research Database
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
ASFA: Aquatic Sciences and Fisheries Abstracts
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality
ProQuest Health & Medical Complete (Alumni)
Aquatic Science & Fisheries Abstracts (ASFA) Professional
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
Aquatic Science & Fisheries Abstracts (ASFA) Professional
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Sustainability
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
Health & Safety Science Abstracts
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ASFA: Aquatic Sciences and Fisheries Abstracts
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList PubMed
Publicly Available Content Database

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitleAlternate Imported dengue viruses in Taiwan, 2011-2016
EISSN 1935-2735
ExternalDocumentID 2252300171
oai_doaj_org_article_9f15f435950648c785914c355ecffd9e
PMC6168156
A557636904
30235208
10_1371_journal_pntd_0006773
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Taiwan
Laos
China
Indonesia
GeographicLocations_xml – name: Taiwan
– name: China
– name: Indonesia
– name: Laos
GrantInformation_xml – fundername: ;
  grantid: MOHW104-CDC-C-315-000101
– fundername: ;
  grantid: MOHW105-CDC-C-315-123603
GroupedDBID ---
123
29O
2WC
53G
5VS
7X7
88E
8C1
8FI
8FJ
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAP
EAS
EBD
ECGQY
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
IHW
ITC
KQ8
M1P
M48
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
H13
IPNFZ
NPM
PJZUB
PPXIY
RIG
WOQ
PMFND
3V.
7QL
7SS
7T2
7T7
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
F1W
FR3
H94
H95
H97
K9.
L.G
M7N
P64
PKEHL
PQEST
PQUKI
7X8
5PM
PUEGO
-
AAPBV
ABPTK
BBAFP
M~E
PRINS
ID FETCH-LOGICAL-c624t-e88c139ec15cccb75bbba686350c8012edae2669a08010ca01ce902cfe1f7a9c3
IEDL.DBID M48
ISSN 1935-2735
1935-2727
IngestDate Sun Sep 04 00:10:38 EDT 2022
Wed Aug 27 01:20:57 EDT 2025
Thu Aug 21 18:19:41 EDT 2025
Fri Jul 11 04:17:42 EDT 2025
Fri Jul 25 04:28:23 EDT 2025
Tue Jun 17 21:11:01 EDT 2025
Tue Jun 10 20:21:58 EDT 2025
Thu May 22 21:19:58 EDT 2025
Mon Jul 21 05:30:19 EDT 2025
Tue Jul 01 02:02:57 EDT 2025
Thu Apr 24 22:52:49 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c624t-e88c139ec15cccb75bbba686350c8012edae2669a08010ca01ce902cfe1f7a9c3
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
The authors do not have commercial or other associations that might pose a conflict of interest with this research.
ORCID 0000-0002-1670-9749
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pntd.0006773
PMID 30235208
PQID 2252300171
PQPubID 1436337
ParticipantIDs plos_journals_2252300171
doaj_primary_oai_doaj_org_article_9f15f435950648c785914c355ecffd9e
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6168156
proquest_miscellaneous_2111154169
proquest_journals_2252300171
gale_infotracmisc_A557636904
gale_infotracacademiconefile_A557636904
gale_healthsolutions_A557636904
pubmed_primary_30235208
crossref_citationtrail_10_1371_journal_pntd_0006773
crossref_primary_10_1371_journal_pntd_0006773
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-09-01
PublicationDateYYYYMMDD 2018-09-01
PublicationDate_xml – month: 09
  year: 2018
  text: 2018-09-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS neglected tropical diseases
PublicationTitleAlternate PLoS Negl Trop Dis
PublicationYear 2018
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References C Klungthong (ref27) 2004; 329
S Nimmannitya (ref8) 1987; 18
JD Thompson (ref22) 1994; 22
JH Huang (ref19) 2012; 87
CK Bodinayake (ref34) 2016; 10
LC Ng (ref37) 2015; 92
JH Huang (ref17) 2007; 77
JP Messina (ref11) 2014; 2
PY Shu (ref16) 2005; 11
JP Messina (ref42) 2014; 22
A A-Nuegoonpipat (ref24) 2004; 329
MG Guzman (ref10) 2015; 385
MR Nunes (ref13) 2014; 8
J Sun (ref35) 2016; 72
DJ Gubler (ref1) 1998; 4
S Kumar (ref23) 2016; 33
SS Twiddy (ref25) 2002; 298
BT Teoh (ref29) 2013; 13
TS Hu (ref30) 2017; 17
S Shihada (ref41) 2015; 23
SF Chang (ref43) 2016; 94
ES Kusmintarsih (ref32) 2017
M Lao (ref40) 2014; 9
NEA Murray (ref12) 2013; 5
BD Lindenbach (ref6) 2003; 59
S Haryanto (ref31) 2016; 110
PY Shu (ref18); 80
S Zangmo (ref38) 2015; 9
SK Tripathi (ref39) 2013; 5
(ref2) 2012
S Fahri (ref28) 2013; 7
CH Calisher (ref5) 1989; 70
(ref9) 2009
RS Lanciotti (ref26) 1994; 75
SQ Shen (ref33) 2015; 5
PY Shu (ref21) 2003; 10
OJ Brady (ref3) 2012; 6
DJ Gubler (ref7) 1997
S Bhatt (ref4) 2013; 496
ST Stoddard (ref14) 2009; 3
LH Chang (ref15) 2007; 44
J Castonguay-Vanier (ref36) 2018; 12
PY Shu (ref20) 2003; 41
References_xml – volume: 496
  start-page: 504
  year: 2013
  ident: ref4
  article-title: The global distribution and burden of dengue
  publication-title: Nature
  doi: 10.1038/nature12060
– volume: 92
  start-page: 1150
  year: 2015
  ident: ref37
  article-title: 2013 dengue outbreaks in Singapore and Malaysia caused by different viral strains
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.14-0588
– volume: 23
  start-page: 272
  year: 2015
  ident: ref41
  article-title: Genetic Diversity and New Lineages of Dengue Virus Serotypes 3 and 4 in Returning Travelers, Germany, 2006–2015
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2302.160751
– volume: 12
  start-page: e0006203
  issue: 1
  year: 2018
  ident: ref36
  article-title: Molecular epidemiology of dengue viruses in three provinces of Lao PDR, 2006–2010
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0006203
– volume: 6
  start-page: e1760
  issue: 8
  year: 2012
  ident: ref3
  article-title: Refining the global spatial limits of dengue virus transmission by evidence-based consensus
  publication-title: PloS Negl Trop Dis
  doi: 10.1371/journal.pntd.0001760
– volume: 298
  start-page: 63
  year: 2002
  ident: ref25
  article-title: Phylogenetic relationships and differential selection pressures among genotypes of dengue-2 virus
  publication-title: Virology
  doi: 10.1006/viro.2002.1447
– volume: 10
  start-page: 622
  year: 2003
  ident: ref21
  article-title: Comparison of capture immunoglobulin M (IgM) and IgG enzyme-linked immunosorbent assay (ELISA) and nonstructural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections
  publication-title: Clin Diagn Lab Immunol
  doi: 10.1128/CDLI.10.4.622-630.2003
– volume: 17
  start-page: e331
  year: 2017
  ident: ref30
  article-title: Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China-Myanmar-Laos border, 2013–2015
  publication-title: BMC Infect Dis
  doi: 10.1186/s12879-017-2401-1
– volume: 22
  start-page: 138
  year: 2014
  ident: ref42
  article-title: Global spread of dengue virus types: mapping the 70 year history
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2013.12.011
– volume: 9
  start-page: e0004010
  issue: 8
  year: 2015
  ident: ref38
  article-title: Epidemiological and Molecular Characterization of Dengue Virus Circulating in Bhutan, 2013–2014
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0004010
– volume: 3
  start-page: e481
  issue: 7
  year: 2009
  ident: ref14
  article-title: The role of human movement in the transmission of vector-borne pathogens
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000481
– volume: 5
  start-page: e16913
  year: 2015
  ident: ref33
  article-title: Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014
  publication-title: Sci Rep
  doi: 10.1038/srep16913
– volume: 22
  start-page: 4673
  year: 1994
  ident: ref22
  article-title: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/22.22.4673
– volume: 33
  start-page: 1870
  year: 2016
  ident: ref23
  article-title: MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets
  publication-title: Mol Biol Evol
  doi: 10.1093/molbev/msw054
– volume: 385
  start-page: 453
  year: 2015
  ident: ref10
  article-title: Dengue
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60572-9
– start-page: 1
  year: 1997
  ident: ref7
  article-title: Dengue and dengue hemorrhagic fever
– volume: 9
  start-page: e115569
  issue: 12
  year: 2014
  ident: ref40
  article-title: Co-Circulation of Dengue Virus Type 3 Genotypes in Vientiane Capital, Lao PDR
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0115569
– volume: 110
  start-page: 119
  year: 2016
  ident: ref31
  article-title: The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015
  publication-title: Pathog Glob Health
  doi: 10.1080/20477724.2016.1184864
– volume: 77
  start-page: 903
  year: 2007
  ident: ref17
  article-title: Laboratory-based dengue surveillance in Taiwan, 2005: A molecular epidemiologic study
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.2007.77.903
– volume: 94
  start-page: 804
  year: 2016
  ident: ref43
  article-title: Laboratory-based surveillance and molecular characterization of dengue viruses in Taiwan, 2014
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.15-0534
– volume: 75
  start-page: 65
  year: 1994
  ident: ref26
  article-title: Molecular evolution and epidemiology of dengue-3 viruses
  publication-title: J Gen Virol
  doi: 10.1099/0022-1317-75-1-65
– volume: 7
  start-page: e2354
  issue: 8
  year: 2013
  ident: ref28
  article-title: Molecular surveillance of dengue in Semarang, Indonesia revealed the circulation of an old genotype of dengue virus serotype-1
  publication-title: PloS Negl Trop Dis
  doi: 10.1371/journal.pntd.0002354
– volume: 80
  start-page: 1039
  ident: ref18
  article-title: Molecular characterization of dengue viruses imported into Taiwan during 2003–2007: Geographic distribution and genotype shift
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.2009.80.1039
– volume: 44
  start-page: 205
  year: 2007
  ident: ref15
  article-title: Differential survival of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) larvae exposed to low temperatures in Taiwan
  publication-title: J Med Entomol
  doi: 10.1093/jmedent/44.2.205
– volume: 70
  start-page: 37
  year: 1989
  ident: ref5
  article-title: Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera
  publication-title: J Gen Virol
  doi: 10.1099/0022-1317-70-1-37
– volume: 41
  start-page: 2408
  year: 2003
  ident: ref20
  article-title: Development of group- and serotype-specific one-step SYBR green I real-time reverse transcription-PCR for dengue virus
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.41.6.2408-2416.2003
– volume: 5
  start-page: 68
  year: 2013
  ident: ref39
  article-title: Emergence of new lineage of Dengue virus 3 (genotype III) in Lucknow, India
  publication-title: Iran J Microbiol
– volume: 2
  start-page: 138
  year: 2014
  ident: ref11
  article-title: Global spread of dengue virus types: mapping the 70 year history
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2013.12.011
– year: 2009
  ident: ref9
– volume: 329
  start-page: 505
  year: 2004
  ident: ref24
  article-title: Sustained transmission of dengue virus type 1 in the Pacific due to repeated introductions of different Asian strains
  publication-title: Virology
  doi: 10.1016/j.virol.2004.08.029
– volume: 13
  start-page: e213
  year: 2013
  ident: ref29
  article-title: Dengue virus type 1 clade replacement in recurring homotypic outbreaks
  publication-title: BMC Evol Biol
  doi: 10.1186/1471-2148-13-213
– volume: 87
  start-page: 349
  year: 2012
  ident: ref19
  article-title: Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2008–2010
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.2012.11-0666
– volume: 11
  start-page: 460
  year: 2005
  ident: ref16
  article-title: Fever screening at airports and imported dengue
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid1103.040420
– year: 2012
  ident: ref2
– volume: 5
  start-page: 299
  year: 2013
  ident: ref12
  article-title: Epidemiology of dengue: past, present and future prospects
  publication-title: Clin Epidemiol
– volume: 8
  start-page: e2769
  issue: 4
  year: 2014
  ident: ref13
  article-title: Air travel is associated with intracontinental spread of dengue virus serotypes 1–3 in Brazil
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0002769
– volume: 4
  start-page: 442
  year: 1998
  ident: ref1
  article-title: Resurgent vector-borne diseases as global health problem
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid0403.980326
– volume: 18
  start-page: 392
  year: 1987
  ident: ref8
  article-title: Clinical spectrum and management of dengue haemorrhagic fever
  publication-title: The Southeast Asian journal of tropical medicine and public health
– year: 2017
  ident: ref32
  article-title: Molecular characterization of dengue viruses isolated from patients in Central Java, Indonesia
  publication-title: J Infect Public Health
– volume: 59
  start-page: 23
  year: 2003
  ident: ref6
  article-title: Molecular biology of flaviviruses
  publication-title: Adv Virus Res
  doi: 10.1016/S0065-3527(03)59002-9
– volume: 72
  start-page: 80
  year: 2016
  ident: ref35
  article-title: The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014
  publication-title: J Infect
  doi: 10.1016/j.jinf.2015.10.007
– volume: 329
  start-page: 168
  year: 2004
  ident: ref27
  article-title: The molecular epidemiology of dengue virus serotype 4 in Bangkok
  publication-title: Thailand. Virology
  doi: 10.1016/j.virol.2004.08.003
– volume: 10
  start-page: e0004995
  issue: 10
  year: 2016
  ident: ref34
  article-title: Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka
  publication-title: PloS Negl Trop Dis
  doi: 10.1371/journal.pntd.0004995
SSID ssj0059581
Score 2.3511715
Snippet A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011-2016. Most of the imported cases arrived from Southeast Asia...
A total of 1,596 laboratory-confirmed imported dengue cases were identified in Taiwan during 2011–2016. Most of the imported cases arrived from Southeast Asia...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e0006773
SubjectTerms Analysis
Biology and Life Sciences
Computer and Information Sciences
Countries
Dengue
Dengue fever
Disease control
Earth Sciences
Ecology and Environmental Sciences
Epidemics
Epidemiology
Gene sequencing
Genetic aspects
Genotypes
Geographical distribution
Human diseases
Medicine and Health Sciences
Microbiological strains
People and Places
Phylogeny
Risk factors
Strains
Strains (organisms)
Transmission
Tropical diseases
Vector-borne diseases
Viral diseases
Viral envelope proteins
Viruses
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9UwDI7QO0xcEDBghQFBQuLUrT-T9rghpmnS47RJu0Wpk0ClR_u01wf_PnbSViuatAuXHhqnUmzX_tLGnxn7bMAIbSodW8hlTKWLcePqJJYaMmegTp2jauT1d3F5U1zdlrf3Wn3RmbBADxwUd1q7tHQFlY9i8qxAEt9aAZglLThnakvRF3PetJkKMRilfXtSRCdUcZXJsWgul-npaKOTbTeYEx-tZb5ISp67f47Qq-2m3z0EP_89RXkvLV08Z89GPMnPwjpesCe2e8kO1uMf80O2WU_9bznM3Myh9JLrznDUMkY_DHg4H28EhhLeO47x6Mfe8t_t3X5nd7z95RnQDW-7oefXuv2jOx5qHLn_AIoX8YrdXHy7_noZjx0WYhBZMcS2qgAhoIW0BIBGlk3TaFEhCEmAUpc12mIGrzXiyjQBnaRg6yQDZ1MndQ35a7bq-s4eMQ4WiKoNAUyVEyjTOgOdNcIiCCBUErF8UrGCkX6cumBslP-nJnEbEjSmyDBqNEzE4nnWNtBvPCJ_TtabZYk8299Al1KjS6nHXCpiH8n2KlSiziFAnZW4OctFnRQR--IlKAjgIkCPtQyoCqLTWkgeLyTx5YXF8BH517SWncLwiptCIjHCmZPPPTz8aR6mh9JZuc72e5ShLFgi0EadvwkuOuuDWkSVWVJFTC6cd6Gw5UjX_vSs4yIVxCz09n9o-B17il5ZhbN6x2w13O3tewR3Q_PBv8d_AdufTF8
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9QwELZgkRAXxLuBAkZC4pQ2b8cnVBBVhbScWmlvkTO2S6QlWTZZ-PvMOE4gqILLHuJxtJkZjz8_5hvG3mrQhdKlCg2kIqTUxbC2MgqFgsRqkLG1lI28_lJcXGWfN_nGb7j1_lrlFBNdoNYd0B75KfodomVid3m_-x5S1Sg6XfUlNG6zO0RdRl4tNvOCK5e5K1KKGIXyrhLhU-dSEZ96S53s2kGfuJgt0sXU5Bj85zi92m27_iYQ-vddyj8mp_MH7L5HlfxsdIOH7JZpH7G7a39u_pht11MVXA4zQ_OYgMlVqznqGmMghj3sjw9GnhLeWY5R6fpg-I9mf-hNz5tvjgdd86YdOn6pmp-q5WOmI3fboPhTPGFX558uP16Evs5CCEWSDaEpS0AgaCDOAaAWeV3XqigRikRAE5jRyuA8LhWiyzgCFcVgZJSANbEVSkL6lK3arjVHjIMBImxDGFOmBM2USkAldWEQChA2CVg6qbgCT0JOtTC2lTtZE7gYGTVWkWEqb5iAhXOv3UjC8R_5D2S9WZYotN2Dbn9d-RFZSRvnNqO8ZERlJQgi8ssA4ZcBa7U0AXtNtq_GfNQ5EFRnOS7R0kJGWcDeOQkKBfgRoHxGA6qCSLUWkscLSRzCsGg-Iv-avqWvfjs79px87ubmN3MzvZRuzLWmO6AMzYU5wm3U-bPRRWd9UKGoPInKgImF8y4Utmxpm6-Oe7yIC-IXev7vv_WC3UN_K8e7eMdsNewP5iWCt6F-5UboL_g8RCU
  priority: 102
  providerName: ProQuest
Title Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2011-2016
URI https://www.ncbi.nlm.nih.gov/pubmed/30235208
https://www.proquest.com/docview/2252300171
https://www.proquest.com/docview/2111154169
https://pubmed.ncbi.nlm.nih.gov/PMC6168156
https://doaj.org/article/9f15f435950648c785914c355ecffd9e
http://dx.doi.org/10.1371/journal.pntd.0006773
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1La9wwEBbJBkovpe-4TbcqFHryYvkl-1BKEhJCYUMpWdibkcdSYtja211vH_--M_KDumzoxQdrZOzRaOaTpfmGsfcFFLEqEuVqCKRLqYtublLPlQp8U0AqjKFs5Pl1fLUIPy-j5QHra7Z2CtzuXdpRPanFZjX79f33J5zwH23VBin6TrN11RQz639lcMiOMDZJqmkwD4d9hSiNEtEl0N3XcxSgLI__4K0n61W93QdF_z1R-VeIunzMHnXYkp-2xvCEHejqKXsw73bPn7HVvK-Fy2HgaW7TMLmqCo4aR0-Izg_7442WrYTXhqNvut1p_qPc7LZ6y8tvlg294GXV1PxGlT9Vxdt8R25_huIlfs4Wlxc351duV23BhdgPG1cnCSAc1CAiAMhllOe5ihMEJB5QGNOF0hjNU4UYU3igPAE69XwwWhipUghesElVV_qYcdBAtG0IZpKAAJpSPig_jzUCAkIoDgt6FWfQUZFTRYxVZvfXJC5JWo1lNDBZNzAOc4de65aK4z_yZzR6gywRadsb9eY26-ZllhoRmZCykxGbJSCJzi8EBGEajClS7bC3NPZZm5U6uIPsNMKFWhCnXuiwD1aCTBQ_AlSX14CqIGqtkeTJSBInMoyaj8m--m_ZZuhqcYFIhEbYs7e5_c3vhmZ6KJ2bq3S9QxmKiBGCbtT5y9ZEB31QuajI9xKHyZHxjhQ2bqnKO8tAHouYWIZe3f_Gr9lDtLWkPY13wibNZqffIHxr8ik7lEuJ1-RcTNnR2cX1l69T-ytkaufqHx13SqQ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKIgEXxLsphRoJxClt3o8DQqVQbWm3p63UW3DGdom0JNtNloo_xW9kxnlAUAWnXvYQj6PNzGTmc-z5hrHXEmQkZCJsBX5sU-minevUsWMBnpaQulpTNfLsNJqeBZ_Pw_MN9rOvhaFjlX1MNIFaVkDfyPfQ7xAtE7vL--WlTV2jaHe1b6HRusWx-nGFS7b63dFHtO8bzzv8ND-Y2l1XARsiL2hslSSAsEeBGwJAHod5nosowcTrAIVrJYXCrJUKxFKuA8JxQaWOB1q5OhYp-HjfW-x24OOrSZXpB8ORkjANTVNUxERU5-XFXameH7t7nWfsLstG7pocEfujVGg6Bgx5YbJcVPV1oPfvs5t_JMPDB-x-h2L5fut2D9mGKh-xO7Nun_4xW8z6rrscBkbotuCTi1JytC3GXAyzOB8vtLwovNIco-DFWvHvxWpdq5oX3wzvuuRF2VR8LoorUfK2spKbz674Ez1hZzdigadsUlal2mQcFBBBHMKmxCcoKIQHwssjhdCDsJDF_F7FGXSk59R7Y5GZnbwYFz-txjIyTNYZxmL2MGvZkn78R_4DWW-QJcpuc6FaXWRdBMhS7YY6oDpoRIEJxEQcGADCPQVay1RZbIdsn7X1r0PgyfZDXBL6UeoEFntrJCj04EOA6CooUBVE4jWS3B5JYsiA0fAm-Vf_LHX2--XCmb3PXT_8ahimm9IJvVJVa5Sh3BsivEedP2tddNAHNaYKPSexWDxy3pHCxiNl8dVwnUduRHxGW__-Wzvs7nQ-O8lOjk6Pn7N76HtJew5wm02a1Vq9QODY5C_N28rZl5sOD78AG2WB5g
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKIlVcEO-mFGokEKe0eTs5IFRaVi1lKw6t1FtwJnYbaUm2mywVf41fx4zzgKAKTr3kEI-jZGY88zmeB2Ovc8gjmcfSVuALm1IX7Uwnji0keDqHxNWaspFnJ9HhWfDpPDxfYz_7XBgKq-xtojHUeQX0j3wX9Q7RMlV32dVdWMSXg-n7xZVNHaTopLVvp9GqyLH6cY3bt_rd0QHK-o3nTT-e7h_aXYcBGyIvaGwVx4AQSIEbAkAmwizLZBSjE3aATLfKpUIPlkjEVa4D0nFBJY4HWrlayAR8fO4ddlf4IqY1Fu8P4SVhEpoGqYiPKOfLE13ano_v32nJzqJs8h3jL4Q_coume8DgIyaLeVXfBID_juP8wzFOH7D7HaLle60KPmRrqnzE1mfdmf1jNp_1HXg5DNWh2-RPLsuco5zR_qLJxfl4o62RwivN0SJerBT_XixXtap58c3UYM95UTYVP5XFtSx5m2XJzS9YvERP2NmtSOApm5RVqTYYBwVULA4hVOwTLJTSA-llkUIYQrjIYn7P4hS6AujUh2OemlM9gRuhlmMpCSbtBGMxe5i1aAuA_If-A0lvoKXy3eZGtbxIO2uQJtoNdUA50YgIYxBURDAAhH4KtM4TZbFtkn3a5sIORijdC3F76EeJE1jsraEgM4QfAbLLpkBWUEGvEeXWiBLNB4yGN0i_-m-p098LDWf2Onfz8KthmB5K0XqlqlZIQ344RKiPPH_WqujAD2pSFXpObDExUt4Rw8YjZXFp6p5HbkS1jTb__VrbbB0NQ_r56OT4ObuHqhe3IYFbbNIsV-oFYsgme2kWK2dfb9s6_AIr4oYc
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+characterization+and+phylogenetic+analysis+of+dengue+viruses+imported+into+Taiwan+during+2011-2016&rft.jtitle=PLoS+neglected+tropical+diseases&rft.au=Cheng-Fen%2C+Yang&rft.au=Chang%2C+Shu-Fen&rft.au=Tung-Chien+Hsu&rft.au=Chien-Ling%2C+Su&rft.date=2018-09-01&rft.pub=Public+Library+of+Science&rft.eissn=1935-2735&rft.volume=12&rft.issue=9&rft_id=info:doi/10.1371%2Fjournal.pntd.0006773&rft.externalDocID=2252300171
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1935-2735&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1935-2735&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1935-2735&client=summon