Diagnostic accuracy of genetic markers and nucleic acid techniques for the detection of Leptospira in clinical samples: A meta-analysis

• Published in: PLoS neglected tropical diseases Vol. 14; no. 2; p. e0008074
• Main Authors: Lam, Jia-Yong, Low, Gary Kim-Kuan, Chee, Hui-Yee
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2020; Public Library of Science (PLoS)
• Subjects: Accuracy; Acids; Agglutination tests; Analysis; Animals; Anopheles; Assaying; Biology and Life Sciences; Detection; Diagnostic systems; Diagnostic tests; Disease; DNA, Bacterial - genetics; Genes; Genetic Markers; Gram-negative bacteria; Health sciences; Heterogeneity; Humans; Isolation; Laboratories; Leptospira; Leptospira - genetics; Leptospira - isolation & purification; Leptospirosis; Leptospirosis - diagnosis; Markers; Medicine and Health Sciences; Meta-analysis; Methods; Nucleic Acid Amplification Techniques - methods; Nucleic acids; Parasitology; Performance evaluation; Physical Sciences; Research and Analysis Methods; Samples; SecY gene; Serological tests; Specificity; Studies; Symptoms; Tropical diseases; India; Selangor Malaysia; Malaysia

Leptospirosis is often difficult to diagnose because of its nonspecific symptoms. The drawbacks of direct isolation and serological tests have led to the increased development of nucleic acid-based assays, which are more rapid and accurate. A meta-analysis was performed to evaluate the diagnostic ac...