Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes

• Published in: Genome medicine Vol. 8; no. 1; p. 17
• Main Authors: Yassour, Moran, Lim, Mi Young, Yun, Hyun Sun, Tickle, Timothy L., Sung, Joohon, Song, Yun-Mi, Lee, Kayoung, Franzosa, Eric A., Morgan, Xochitl C., Gevers, Dirk, Lander, Eric S., Xavier, Ramnik J., Birren, Bruce W., Ko, GwangPyo, Huttenhower, Curtis
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2016; BioMed Central
• Subjects: Adult; Biological markers; Diabetes Mellitus, Type 2 - microbiology; Dysbiosis - microbiology; Feces - microbiology; Female; Gastrointestinal diseases; Gastrointestinal Microbiome; Healthy Volunteers; Humans; Male; Microbiota (Symbiotic organisms); Middle Aged; Obesity; Obesity - microbiology; Phylogeny; Risk Factors; Twins; Twins, Monozygotic; Type 2 diabetes; Verrucomicrobia - classification; Verrucomicrobia - genetics; Verrucomicrobia - isolation & purification

Obesity and type 2 diabetes (T2D) are linked both with host genetics and with environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede disease onset. Twin cohorts present a unique genetically-controlled opportunity to study the...