Impact of Enterobius vermicularis infection and mebendazole treatment on intestinal microbiota and host immune response

• Published in: PLoS neglected tropical diseases Vol. 11; no. 9; p. e0005963
• Main Authors: Yang, Chin-An, Liang, Chao, Lin, Chia-Li, Hsiao, Chiung-Tzu, Peng, Ching-Tien, Lin, Hung-Chih, Chang, Jan-Gowth
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2017; Public Library of Science (PLoS)
• Subjects: Abundance; Actinobacteria; Animals; Arthritis; Autoimmune diseases; Bacteria; Bifidobacterium - drug effects; Bifidobacterium - genetics; Bifidobacterium - growth & development; Bifidobacterium - isolation & purification; Biology and Life Sciences; Child; Child, Preschool; Children; Composition; Computational Biology; Cytokines - biosynthesis; Cytokines - immunology; Defence mechanisms; Diabetes; Digestive system; Digestive tract; Disease; Enterobiasis; Enterobiasis - drug therapy; Enterobiasis - immunology; Enterobiasis - microbiology; Enterobiasis - parasitology; Enterobius - drug effects; Enterobius - genetics; Enterobius - immunology; Enterobius vermicularis; Exposure; Feces - parasitology; Female; Funding; Fusobacteria; Fusobacteria - drug effects; Fusobacteria - genetics; Fusobacteria - growth & development; Fusobacteria - isolation & purification; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - genetics; Gastrointestinal tract; Gene expression; Genetic aspects; Health aspects; Hospitals; Humans; Hypotheses; Immune response; Immune system; Immunity; Immunity - drug effects; Immunoglobulin A, Secretory - analysis; Immunoglobulin A, Secretory - immunology; Infections; Inflammatory bowel disease; Inflammatory diseases; Intestinal flora; Intestinal microflora; Intestine; Intestines - drug effects; Intestines - immunology; Intestines - microbiology; Intestines - parasitology; Irritable bowel syndrome; Laboratories; Male; Mebendazole; Mebendazole - administration & dosage; Mebendazole - therapeutic use; Medicine; Medicine and Health Sciences; Microbiomes; Microbiota (Symbiotic organisms); Microorganisms; Patient outcomes; Pediatrics; Physiological aspects; Probiotics; Relative abundance; Salmonella; Salmonella - drug effects; Salmonella - genetics; Salmonella - growth & development; Salmonella - isolation & purification; Studies; Supervision; Taiwan - epidemiology; Tropical diseases; Tumors; China; Taiwan

Previous studies on the association of enterobiasis and chronic inflammatory diseases have revealed contradictory results. The interaction of Enterobius vermicularis infection in particular with gut microbiota and induced immune responses has never been thoroughly examined. In order to answer the qu...