Collocation of avian and mammal antibodies to develop a rapid and sensitive diagnostic tool for Russell's Vipers Snakebite

• Published in: PLoS neglected tropical diseases Vol. 14; no. 9; p. e0008701
• Main Authors: Lin, Jing-Hua, Lo, Che-Min, Chuang, Ssu-Han, Chiang, Chao-Hung, Wang, Sheng-Der, Lin, Tsung-Yi, Liao, Jiunn-Wang, Hung, Dong-Zong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2020; Public Library of Science (PLoS)
• Subjects: Acute Kidney Injury; Animals; Antibodies; Antibodies - isolation & purification; Antivenins - immunology; Antivenom; Aquatic birds; Asia; Asia, Southeastern; Biology and Life Sciences; Birds - immunology; Bites and stings; Bleeding; Care and treatment; Councils; Cross-reactivity; Daboia; Detection; Diagnostic software; Diagnostic systems; Diagnostic Tests, Routine; Egg yolk; Eggs; Elapid Venoms; ELISA; Enzyme-Linked Immunosorbent Assay; Field investigations; Field tests; Funding; Geese - immunology; Haemolysis; Hemorrhage; Horses - immunology; Hospitals; Humans; Immunoassay; Immunoglobulins; Immunotherapy; In vitro methods and tests; Livestock; Mammals; Mammals - immunology; Medicine and Health Sciences; Methods; Microfluidics; Patient outcomes; Proteins; Public health; Regional development; Research and Analysis Methods; Samples; Serum; Snake bites; Snake Bites - diagnosis; Snake Bites - immunology; Snakes; Testing; Toxicology; Tropical diseases; Venom; Venoms - immunology; Viral antibodies; Waterfowl; Western blotting; Wounds; Asia, Southeastern; Asia; Taiwan; United States > US; China

Russell's vipers (RVs) envenoming is an important public health issue in South-East Asia. Disseminated intravascular coagulopathy, systemic bleeding, hemolysis, and acute renal injury are obvious problems that develop in most cases, and neuromuscular junction blocks are an additional problem ca...