Systemic Fluorescent Gentamicin Enters Neonatal Mouse Hair Cells Predominantly Through Sensory Mechanoelectrical Transduction Channels

• Published in: Journal of the Association for Research in Otolaryngology Vol. 21; no. 2; pp. 137 - 149
• Main Authors: Makabe, Ayane, Kawashima, Yoshiyuki, Sakamaki, Yuriko, Maruyama, Ayako, Fujikawa, Taro, Ito, Taku, Kurima, Kiyoto, Griffith, Andrew J., Tsutsumi, Takeshi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2020; Springer Nature B.V
• Subjects: Aminoglycoside antibiotics; Antibiotics; Apoptosis; Endocytosis; Gentamicin; Hair cells; Hearing protection; Inner ear; Ion channels; Medicine; Medicine & Public Health; Neonates; Neurobiology; Neurosciences; Newborn babies; Otorhinolaryngology; Research Article; Signal transduction; Transient receptor potential proteins; Transmission electron microscopy; TMC1; aminoglycoside; ototoxicity; hair cell; TMC2

Systemically administered aminoglycoside antibiotics can enter inner ear hair cells and trigger apoptosis. However, the in vivo route(s) by which aminoglycoside antibiotics enter hair cells remains controversial. Aminoglycosides can enter mouse hair cells by endocytosis or by permeation through tran...